A5019830935- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- vaccines and immunoinformatics approaches
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Gene Regulatory Network Analysis
- T-cell and B-cell Immunology
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Integrated Energy Systems Optimization
- Proteoglycans and glycosaminoglycans research
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Medicinal Plant Pharmacodynamics Research
- Synthesis of Indole Derivatives
- Liver physiology and pathology
Wenzhou Central Hospital
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2025
Wenzhou Medical University
2022-2025
Center for Excellence in Molecular Cell Science
2020-2024
Chinese Academy of Sciences
2020-2024
Lanzhou University Second Hospital
2022-2024
Lanzhou University
2022-2024
University of Southampton
2024
University of Chinese Academy of Sciences
2020-2023
ShanghaiTech University
2020-2023
Abstract Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated pathways, promoted...
Purpose This study compared the efficacy and acceptability of a ready-to-use intranasal dexmedetomidine spray (DS) versus traditional drops administered by syringe (DD) in pediatric patients undergoing elective surgery. Patients Methods Eighty-six preschool children were enrolled prospective, randomized, controlled study. Children randomly assigned to receive either DS or DD. For weighing between 10.5 18.5 kg, dosage 30 μg (two sprays) was administered, while those 25.5 kg received 45 (three...
Systemic Lupus Erythematosus (SLE) etiopathogenesis highlights the contributions of overproduction CD4
The Cuiguan pear is called "June snow" and the skin thin; meat crisp juicy; taste thick fresh; juice rich sweet. In this study, volatile organic compounds sensory physicochemical parameters of from four different regions China (Sichuan (SC), Shangdong (SD), Chongming (CM), Zhuanghang (ZH)) were assessed. highest differences in observed between regions. fingerprints GC-IMS showed great pear, which suggested that aroma pears could be largely impacted by origin areas. (E)-ethyl-2-hexenoate can...
Abstract Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non–small cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Experimental Design: We integrated clinical, genomic, and survival data 427 NSCLC treated first-line or from two phase III trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved objective...
Abstract Purpose: The molecular complexity of acute myeloid leukemia (AML) presents a considerable challenge to implementation clinical genetic testing for accurate risk stratification. Identification better biomarkers therefore remains high priority enable improving established stratification and guiding risk-adapted therapy decisions. Experimental Design: We systematically integrated analyzed the genome-wide CRISPR-Cas9 data from more than 1,000 in vitro vivo knockout screens identify...
During liver development, hepatocytes, and cholangiocytes are concurrently differentiated from common progenitor cells assembled into hepatobiliary architecture to perform proper hepatic function. However, the generation of functional hepatocytes in vitro is still challenging, exact molecular drivers cell lineage determination largely unknown. In this study, organoids (HBOs) generated hepatocytes. These HBOs contain a bile duct network surrounded by mature stably maintain characteristics...
Abstract Purpose This study was to explore the efficacy of Bruton's tyrosine kinase inhibitor (BTKi) in treating patients with central high-risk systemic diffuse large B cell lymphoma (DLBCL) and primary nervous system (PCNSL), while also assessing influence genomic variants on treatment outcomes. Materials methods The safety, efficacy, prognosis treated BTKi-containing regimens were analyzed. Genetic analyzed using whole-exome sequencing (WES). Results Of 10 DLBCL, nine completed available...
Background: Pacemaker implantation combined with atrioventricular node ablation (AVNA) could be a practical choice for atrial fibrillation (AF) patients heart failure (HF). Left bundle branch area pacing (LBBaP) has been widely reported. Objectives: To explore the safety and efficacy of LBBaP AVNA in AF HF. Methods results: Fifty-six HF attempted from January 2019 to December 2020. Standard was achieved forty-six patients, another ten received left ventricular septal (LVSP). The cardiac...
We developed a new computational method, Single-Cell Entropy Network (SCEN) to analyze single-cell RNA-seq data, which used the information of gene-gene associations discover heterogeneity immune cells as well identify existing cell types. Based on SCEN, we defined association-entropy (AE) for each and gene through co-expression networks measure strength association between all other genes at resolution. Analyses public datasets indicated that AE ribosomal protein (RP genes) varied greatly...
<p>Supplementary methods and Figure S1-S12</p>
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<p>Supplementary methods and Figure S1-S12</p>
To investigate gene mutation characteristics of primary central nervous system lymphoma (PCNSL) through whole exome sequencing (WES) to 18 patients with PCNSL.