A5037180370- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Single-cell and spatial transcriptomics
- Hepatitis B Virus Studies
- RNA modifications and cancer
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Institute of Hematology
2024
Peking University First Hospital
2009
Peking University
2009
Abstract Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated pathways, promoted...
Acute myeloid leukemia (AML) has lagged in benefiting from immunotherapies, primarily due to the scarcity of actionable AML-specific antigens. Driver mutations represent promising immunogenic targets, but a comprehensive characterization AML neoantigen landscape and their impact on patient outcomes immune microenvironment remain unclear. Herein, we conducted matched DNA RNA sequencing 304 patients extensively integrated data additional ∼2,500 cases, identifying 49 driver genes, notably...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<div>Abstract<p>Patients with primary refractory acute myeloid leukemia (AML) have a dismal long-term prognosis. Elucidating the resistance mechanisms to induction chemotherapy could help identify strategies improve AML patient outcomes. Herein, we retrospectively analyzed multiomics data of more than 1,500 cases and found that patients spliceosome mutations had higher risk developing disease. RNA splicing analysis revealed mis-spliced genes in converged on translation-associated...
<p>Supplementary methods and Figure S1-S12</p>
<p>Supplementary methods and Figure S1-S12</p>
Introduction Acute myeloid leukemia (AML) is an aggressive blood cancer with high heterogeneity and poor prognosis. Although the metabolic reprogramming of nicotinamide adenine dinucleotide (NAD) has been reported to play a pivotal role in pathogenesis acute (AML), prognostic value NAD metabolism its correlation immune microenvironment AML remains unclear. Methods We utilized our large-scale RNA-seq data on 655 patients metabolism-related genes establish score based sparse regression...
We report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had 14-year history of HCV infection positive serum RNA at presentation. Diagnosis HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen mainly detected as granular deposition glomerular mesangium. amyloidosis determined by electron microscopy, Congo red staining identification λ-chain kidney specimen monoclonal IgG-λ urine. Under...