A5044566840- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Plant Pathogens and Fungal Diseases
- Postharvest Quality and Shelf Life Management
- Plant-Microbe Interactions and Immunity
- Plant Physiology and Cultivation Studies
- vaccines and immunoinformatics approaches
- Plant Disease Resistance and Genetics
- Mycotoxins in Agriculture and Food
- Fungal Plant Pathogen Control
- Proteoglycans and glycosaminoglycans research
- 3D Printing in Biomedical Research
- Mycorrhizal Fungi and Plant Interactions
- Neuropeptides and Animal Physiology
- Medical Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Oral and gingival health research
- Immune cells in cancer
- Acute Kidney Injury Research
- Fungal Biology and Applications
- Drug Solubulity and Delivery Systems
- Healthcare and Venom Research
- Nuts composition and effects
- Receptor Mechanisms and Signaling
East China Normal University
2020-2024
Sichuan Agricultural University
2018-2024
Genecast (China)
2023
Shandong University
2020
Dahua Hospital
2017
Tianjin Infectious Diseases Hospital
2017
Tianjin Medical University
2017
South China University of Technology
2013
Colletotrichum gloeosporioides, an important phytopathogenic fungus, mainly infects tropical fruits and results in serious anthracnose. Previous studies have shown that melanin biosynthesis inhibitor can inhibit the melanization of appressoria Magnaporthe grisea orbiculare, resulting limited infection hosts. In this study, we identified characterized a scytalone dehydratase gene (CgSCD1) from C. gloeosporioides which is involved synthesis. The CgSCD1 deletion mutant ΔCgscd1 was obtained...
is a typical necrotrophic plant pathogenic fungus which can deliberately acidify host tissues and trigger oxidative bursts therein to facilitate its virulence. The white collar complex (WCC), consisting of BcWCL1 BcWCL2, recognized as the primary light receptor in
Little is known about the hypolipidemic activity of okra; therefore, we investigated okra and its interaction with gene expression several key components involved in lipid homeostasis. Male C57BL/6 mice were randomly divided into three groups fed hyperlipidemic diet or two diets supplemented 1% 2% powder for eight weeks. Results demonstrated that dose‐dependently decreased serum hepatic total cholesterol triglyceride, enhanced fecal excretion bile acids. Gene analysis revealed upregulated...
Abstract Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non–small cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Experimental Design: We integrated clinical, genomic, and survival data 427 NSCLC treated first-line or from two phase III trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved objective...
Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility poor oral bioavailability limit clinical application.To overcome the shortcomings, toltrazuril-hydroxypropyl-β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared characterized. The comparative plasma disposition kinetics of Tol analyzed after a single orally administered dose 10 mg/kg or Tol-HP-β-CD in rabbits. Solution-stirring method selected prepare complex. Complex formation...
Recent studies have shown that programmed cell death 4 (PDCD4) modulates distinct signal transduction pathways in different pathological conditions. Despite acute and chronic immune responses elicited by ischemia contributing to the functional deterioration of kidney, contributions mechanisms PDCD4 kidney injury (AKI) remained unclear. Using two murine AKI models including renal ischemia/reperfusion (IRI) cisplatin-induced AKI, we found deficiency markedly ameliorated dysfunction...
Ethylene (ET) represents a signal that can be sensed by plant pathogenic fungi to accelerate their spore germination and subsequent infection. However, the molecular mechanisms of responses ET in remain largely unclear. In this study, Colletotrichum gloeosporioides was investigated via transcriptomic analysis reveal genes account for ET-regulated fungal development virulence. The results showed promoted encoding melanin biosynthesis enzymes, extracellular hydrolases, appressorium-associated...
N1-(2-chloro-4-pyridyl)-N3-phenylurea (CPPU), a synthetic cytokinin-active compound, is widely applied to induce parthenocarpic fruit set and enhance melon enlargement (Cucumis melo L.). CPPU may also influence quality; however, the mechanisms through which this occurs remain unknown. We investigated differences in volatile emissions between by (C) seeded artificial pollination (P). Gas chromatography–mass spectrometry (GC–MS) analysis revealed that six organic compounds (VOCs) emitted...
Abstract Objectives The gray mold fungus Botrytis cinerea (B. cinerea) infects a wide range of crops before and after harvest, causing huge losses worldwide. Inhibition mechanisms B. in vitro plants by calcium propionate (CP), generally recognized as safe substance, are described this study. Materials methods Wild-type transgenic mutant strains were used the study to evaluate effects CP on fungal growth development vitro. Plant materials including tomato leaves table grapes tested for...
Fusarium asiaticum is an epidemiologically important pathogen of cereal crops in east Asia, accounting for both yield losses and mycotoxin contamination problems food feed products. FaWC1, a component the blue-light receptor White Collar complex (WCC), relies on its transcriptional regulatory zinc finger domain rather than light-oxygen-voltage to regulate pathogenicity F. asiaticum, although downstream mechanisms remain obscure. In this study, factors regulated by FaWC1 were analyzed. It was...
<p>Supplementary Materials</p>
<div>Abstract<p>Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non-small-cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Patients and Methods: We integrated clinical, genomic survival data 427 NSCLC treated first-line or from two phase 3 trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved...
<p>Supplementary Materials</p>
<div>AbstractPurpose:<p>PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non–small cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined.</p>Experimental Design:<p>We integrated clinical, genomic, and survival data 427 NSCLC treated first-line PD-1 or from two phase III trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence...
<div>Abstract<p>Purpose: PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non-small-cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined. Patients and Methods: We integrated clinical, genomic survival data 427 NSCLC treated first-line or from two phase 3 trials (CameL CameL-sq) investigated prognostic value HLA class I evolutionary divergence (HED). Results: High HED could predict significantly improved...
<p>Supplementary Materials</p>