A5100740946- Crystallization and Solubility Studies
- Antibiotic Resistance in Bacteria
- Pharmacological Effects of Natural Compounds
- Animal Nutrition and Physiology
- Bacterial biofilms and quorum sensing
- Chemical and Physical Properties in Aqueous Solutions
- Chemical Thermodynamics and Molecular Structure
- Antimicrobial Resistance in Staphylococcus
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Escherichia coli research studies
- Plant-based Medicinal Research
- Antimicrobial Peptides and Activities
- Gut microbiota and health
- Microbial Metabolism and Applications
- Vibrio bacteria research studies
- Immune Response and Inflammation
- Alkaloids: synthesis and pharmacology
- Rabbits: Nutrition, Reproduction, Health
- Fluoride Effects and Removal
- Toxin Mechanisms and Immunotoxins
- Biochemical and Structural Characterization
- Trace Elements in Health
- Metabolomics and Mass Spectrometry Studies
Sichuan Agricultural University
2010-2025
Extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) strains are emerging around the world as a source of resistance to β-lactam antibiotics such ampicillin, cefotaxime, and ceftazidime. mcr-1 is novel plasmid-mediated gene conferring colistin. The aim this study was investigate prevalence ESBL-EC chicken origin in different provinces China during 2008-2014. Overall, 341 821 isolates were determined be strains, proportion ESBL-positive almost doubled from 2008 2014. findings...
Resveratrol (Res) is a natural compound that possesses anti‑inflammatory properties. However, the protective molecular mechanisms of Res against lipopolysaccharide (LPS)‑induced inflammation have not been fully studied. In present study, RAW264.7 cells were stimulated with LPS in presence or absence Res, and subsequent modifications to LPS‑induced signaling pathways caused by treatment examined. It was identified decreased mRNA levels Toll‑like receptor 4 (TLR4), myeloid differentiation...
Pseudomonas aeruginosa (P. aeruginosa), one of the dangerous multidrug resistance pathogens, orchestrates virulence factors production through quorum sensing (QS). Since exploration QS inhibitors, targeting to circumvent bacterial pathogenesis without causing significant growth inhibition is a promising approach treat P. infections. The present study has evaluated anti-QS and anti-infective activity epigallocatechin-3-gallate (EGCG), bioactive ingredient traditional green tea, against...
Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against wide range viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been elucidated. In this paper, antiviral PRV mechanism action were investigated. The results showed that potently inhibited replication dose-dependent manner, with 50% inhibition...
With continuous emergence and widespread of multidrug-resistant Staphylococcus aureus infections, common antibiotics have become ineffective in treating these infections the clinical setting. Anti-virulence strategies could be novel, effective therapeutic against drug-resistant bacterial infections. Sortase A (srtA), a transpeptidase gram-positive bacteria, can anchor surface proteins that play vital role pathogenesis bacteria. SrtA is known as potential antivirulent drug target to treat In...
Context: Methicillin-resistant Staphylococcus aureus (MRSA) is a very harmful bacterium. Oridonin, component in Rabdosia rubescens (Hemsl.) Hara (Lamiaceae), widely used against bacterial infections China. Objective: We evaluated oridonin effects on MRSA cell membrane and wall, protein metabolism, lactate dehydrogenase (LDH), DNA microscopic structure. Materials methods: Broth microdilution flat colony counting methods were to measure minimal inhibitory concentration (MIC) minimum...
Methicillin-resistant Staphylococcus aureus (MRSA) is a common human pathogen that causes several difficult-to-treat infections, including biofilm-associated infections. The biofilm-forming ability of S. plays pivotal role in its resistance to most currently available antibiotics, vancomycin, which the first-choice drug for treating MRSA In this study, thymol (a monoterpenoid phenol isolated from plants) inhibit biofilm formation and eliminate mature biofilms, was assessed. We found could...
Abstract It has been shown that bamboo leaf flavone (BLF) displays biological and pharmacological activities in mammals. However, the effects of BLF on broiler gut microbiota related immune function have not investigated. The aim this study was to test our hypothesis can improve health status broilers by modulating microbiota. A total 300 one-day-old Arbor Acres (AA) were used characterize their after feeding diet supplemented with BLF. V4 hypervariable region 16S rRNA gene from cecal...
Abstract Background Staphylococcus aureus ( S. ), especially methicillin-resistant (MRSA), is considered a common zoonotic pathogen, causing severe infections. The objective of this study was to investigate the antimicrobial susceptibility, resistance genes and molecular epidemiology among MRSA methicillin-susceptible (MSSA) isolated from food animals in Sichuan Province, China. Methods This conducted on 236 isolates. All isolates were subjected susceptibility testing by using standard...
Introduction: Chrysin has a wide range of biological activities, but its poor bioavailability greatly limits use. Here, we attempted to prepare casein (cas)-based nanoparticles promote the biotransfer chrysin, which demonstrated better and anti-infection activity compared free chrysin. Methods: Cas-based chrysin were prepared characterized, most preparation process was optimized. Then, in vitro vivo release characteristics studied, anti-pulmonary infection evaluated. Results: The constructed...
Biofilm-associated lung infections, particularly those caused by Staphylococcus aureus (S. aureus), pose significant clinical challenges to conventional therapies. S. Biofilm infections are refractory treatment due the presence of persister bacterial cells and barrier effect unique extracellular polymeric substances (EPS). This study describes development multifunctional micelles, HK-SL Ms, utilizing sophorolipid (SL) encapsulate Honokiol (HK). Ms potently disrupted EPS barrier, killed some...
Post-weaning Diarrhea (PWD) is a kind of physiological stress diarrhea in Rex rabbits after weaning, which can lead to death severe cases. Traditional Chinese medicine (TCM) has been widely used animal due its advantages natural origin, diverse functions, safety, reliability, economy and environmental protection. Modified Yupingfeng Granule (MYPFG) an improved prescription based on the famous traditional (YPF), combined with other TCM obvious synergistic additive activity order obtain...
Lipopolysaccharide (LPS) has been considered the primary agent to establish animal models of inflammation, immunological stress, and organ injury. Previous studies have demonstrated that LPS impaired gastrointestinal development disrupted intestinal microbial composition metabolism. Ferulic acid (FA) isolated from multiple plants exhibits biological activities. This study investigated whether FA ameliorated function microflora in LPS-challenged Tianfu broilers. The results showed challenge...
The objectives of this study were to develop and optimize ultrasound‐assisted extraction (UAE) for shikonin from Arnebia euchroma using response surface methodology (RSM) evaluate the antimicrobial activity shikonin. maximum yield was 1.26% under optimal conditions (ultrasound power, 93 W; time, 87 min; temperature, 39°C; liquid‐solid ratio, 11 : 1). Shikonin showed inhibitory against standard strains clinical isolates varying extents (MICs ranging 128 1024 μ g/mL, MBCs 256 2048 g/mL), it...