A5074248921- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Oral microbiology and periodontitis research
- Biochemical and Structural Characterization
- Antibiotic Resistance in Bacteria
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Animal Ecology and Behavior Studies
- Virus-based gene therapy research
- Gut microbiota and health
- Ecology and Vegetation Dynamics Studies
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Microbial Metabolism and Applications
- Medicinal plant effects and applications
- Inflammasome and immune disorders
- Ginger and Zingiberaceae research
- Salmonella and Campylobacter epidemiology
- Advancements in Transdermal Drug Delivery
- Rangeland and Wildlife Management
- NF-κB Signaling Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Seed Germination and Physiology
- Bone Metabolism and Diseases
Southwest University
2015-2024
Tarim University
2024
Xinjiang Production and Construction Corps
2024
Hainan Medical University
2024
Shihezi University
2005-2023
South China Institute of Collaborative Innovation
2023
Harbin Medical University
2021
Luoyang Central Hospital Affiliated to Zhengzhou University
2018
Nanchang University
2015
First Affiliated Hospital of Nanchang University
2015
Abstract P . aeruginosa is a notorious biofilm producer that causes wide variety of acute and chronic infections. In this study the in vitro anti-biofilm activity 13 Host Defence Peptides from different species was tested against biofilms. Most HDPs were able to prevent attachment, due their antimicrobial effect on planktonic bacteria starting inoculum. Activity pre-formed biofilms also observed, although mainly at short incubation times. Several kill (colony counting associated bacteria)...
In the large poultry industry, where farmed chickens are fed at high density, prevalence of pathogens and repeated vaccinations induce immune stress, which can significantly decrease production performance increase mortality. This study was designed to shed light on molecular mechanisms metabolic pathways involved in stress through an in-depth analysis transcriptomic metabolomic changes jejunum samples from broilers. Two groups were established for experiment: a control group LPS group....
Pseudomonas aeruginosa (P. aeruginosa), one of the dangerous multidrug resistance pathogens, orchestrates virulence factors production through quorum sensing (QS). Since exploration QS inhibitors, targeting to circumvent bacterial pathogenesis without causing significant growth inhibition is a promising approach treat P. infections. The present study has evaluated anti-QS and anti-infective activity epigallocatechin-3-gallate (EGCG), bioactive ingredient traditional green tea, against...
Biofilms often engender persistent infections, heightened antibiotic resistance, and the recurrence of infections. Therefor, infections related to bacterial biofilms are chronic pose challenges in terms treatment. The main transcription regulatory factor, CsgD, activates csgABC-encoded curli participate composition extracellular matrix, which is an important skeleton for biofilm development enterobacteriaceae. In our previous study, a wide range natural bioactive compounds that exhibit...
With the increasing bacterial resistance to traditional antibiotics, there is an urgent need for development of alternative drugs or adjuvants antibiotics enhance antibacterial efficiency. The combination antimicrobial peptides (AMPs) and a potential In this study, we investigated synergistic bactericidal effect AMPs, including chicken (CATH-1,-2,-3, -B1), mice (CRAMP), porcine (PMAP-36 PR-39) in with conventional containing ampicillin, tetracycline, gentamicin, erythromycin against...
Acinetobacter lwoffii (A.lwoffii) is a serious zoonotic pathogen that has been identified as cause of infections such meningitis, bacteremia and pneumonia. In recent years, the infection rate detection A.lwoffii increasing, especially in breeding industry. Due to presence biofilms, it difficult eradicate become potential super drug-resistant bacteria. Therefore, eradication preformed biofilm an alternative therapeutic action control infection. The present study aimed clarify baicalin could...
Pseudomonas aeruginosa (P. aeruginosa) is a known bacterium that produces biofilms and causes severe infection. Furthermore, P. are extremely difficult to eradicate, leading the development of chronic antibiotic-resistant infections. Our previous study showed cathelicidin-related antimicrobial peptide (CRAMP) inhibits formation markedly reduces biomass preformed biofilms, while mechanism eradicating bacterial remains elusive. Therefore, in this study, potential by which CRAMP eradicates was...
Primary hepatocellular carcinoma (HCC) is one of the most common malignant tumors. At present, molecular mechanism HCC remains unclear. A recent circular RNA (circRNA) profiling study showed that circRBM23 expression was upregulated in tissues. Therefore, this study, impact during progression evaluated. The levels and miR-138 tissues cell lines were determined by RT-PCR results indicated increased lines, whereas decreased. An upregulation cells shown to increase viability, also ability...
Dairy mastitis is one of the most common diseases in dairy farming, and formation pathogenic bacteria biofilms may be an important reason why traditional antibiotic therapy fails to resolve some cases mastitis. We isolated identified three strains A. lwoffii were with strong biofilm forming ability from cow samples Chongqing farms China. In order investigate effect novel anti-biofilm peptide CRAMP-34 on A.lwoffii biofilms, was evaluated by crystal violet staining, viable counting confocal...
Abstract When skin comes into direct contact with the outside environment, it becomes extremely prone to injury and external factors can make wounds difficult heal. Traditional medical dressings often cause secondary are poorly resistant infection. Hydrogels offer a promising alternative overcome these difficulties. In this study, chitosan (CS)/gelatin (GEL)/polyvinyl alcohol (PVA) hydrogels were developed by chemical cross-linking loaded drug kitasamycin (KM) for testing. The hydrogels’ in...
The desert ecosystem is an important ecological barrier to prevent desertification and maintain the stability of arid zone regional security. degree change species composition pioneer during early spring recovery community can be used as indicators ecology predict subsequent in spring. Rodents serve engineers through their behavior, they influence biological communities. In this study, we analyzed correlations between soil physicochemical properties, assembly, plant diversity microbial areas...
Identifying or prioritizing genes for chronic obstructive pulmonary disease (COPD), one type of complex disease, is particularly important its prevention and treatment.In this paper, a novel method was proposed to Prioritize using Expression information in Protein-protein interaction networks with risks transferred between (abbreviated as PEP). A weighted COPD PPI network constructed expression then candidate were prioritized based on their corresponding risk scores descending order.Further...
Abstract Nutrients form a link between herbivores and plant. This study explored the physiological ecological response mechanism of Haloxylon ammodendron population to rodent disturbance in Gurbantunggut Desert from perspective nutrient cycle. Through field investigation, we quantified intensity (DI) H. analyzed plant soil cycling changes. The results indicated that moderate DI (number effective burrows = 3–6) was maximum limit can be tolerated by ; threshold for optimal mild 1–3)....
To compare the pharmacokinetics of cefquinome sulfate in ducklings and goslings after IV or IM administration a single dose.216 healthy Muscovy (Cairina moschata) 216 Sichuan white (Anser cygnoides).Ducklings were each randomly assigned to 3 groups (n = 72/group) that received dose (2 mg/kg) injectable administered suspension IM. Blood samples collected at various points drug 6 birds/time point). Plasma concentrations measured by high-performance liquid chromatography with UV detection,...
Probiotics can improve the microecological balance of body and have special effects in promoting nutrient absorption, controlling intestinal infections, regulating immune function. However, there are problems such as difficult colonization gastrointestinal environment low oral bioavailability. Bacterial biofilms organized bacterial cells that adhere to an abiotic or biotic surface enclosed extracellular polymeric substances exopolysaccharides (EPS), DNA (eDNA), proteins lipids, with a...
Abstract Chicken cathelicidin-2 (CATH-2) as a host defense peptide has been identified to have potent antimicrobial and immunomodulatory activities. Here, we reported the mechanism by which CATH-2 modulates NLRP3 inflammasome activation. Our results show that ATP positive control induced secretion of IL-1β IL-1α in LPS-primed macrophages but did not affect IL-6, IL-12 TNF-α. Furthermore, caspase-1 activation oligomerization apoptosis-associated speck-like protein containing carboxy- terminal...
Probiotic biofilms have been beneficial in the fight against infections, restoring equilibrium of host’s gut microbiota, and enhancing host health. They are considered a novel strategy for probiotic colonization. In this case, we evaluated effects various active substances from traditional Chinese medicine on Escherichia coli Nissle 1917 (EcN) to determine if they promote biofilm formation. It was shown that 8–64 μg/mL oleanolic acid increased development EcN biofilm. Additionally, observed...
Abstract Escherichia coli ( E. ) has high antimicrobial resistance and is globally prevalent, forming aggressive dense bacterial biofilms. Previous studies have shown that the mouse peptide CRAMP-34 eradicates The current study aimed to investigate mechanism of on biofilm a clinically isolated No. Ec032) with strong formation ability. An unreported gene kduD associated Ec032 was identified by transposon mutation technology, deletion strain Ec032Δ constructed using CRISPR/Cas9. Furthermore,...
Biofilm is a structured community of bacteria encased within self-produced extracellular matrix. When form biofilms, they undergo phenotypic shift that enhances their resistance to antimicrobial agents. Consequently, inducing the transition biofilm planktonic state may offer viable approach for addressing infections associated with biofilms. Our previous study has shown mouse peptide CRAMP-34 can disperse Pseudomonas aeruginosa ( P. ) biofilm, and potential mechanism eradicate biofilms was...
Aim: The aim was to explore the epigenetic mechanisms underlying cervical oncogenesis, we compared level of microRNA-34a (miR-34a), p53, and cell cycle-related protein CDK4 within normal tissue, intraepithelial neoplasia III (CINIII) cancer tissue. Methods: Fresh CINIII tissue specimens were collected from patients not receiving chemotherapy, radiotherapy or immunotherapy prior surgery. Stem-loop real-time polymerase chain reaction employed analyze miR-34a. p53 detected by...