A5053795618- Animal Virus Infections Studies
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Antimicrobial Peptides and Activities
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Mycobacterium research and diagnosis
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Toxoplasma gondii Research Studies
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Advanced Algorithms and Applications
- Microbial infections and disease research
- Industrial Technology and Control Systems
- Gut microbiota and health
- interferon and immune responses
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Diet, Metabolism, and Disease
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
Chongqing Academy of Animal Science
2010-2024
Central South University
2022-2024
South China Institute of Collaborative Innovation
2023
Changsha University of Science and Technology
2022
Hunan Normal University
2022
Georgia State University
2014-2020
Yale University
2015
Southwest University
2013
Yangzhou University
2010
Jiaozuo University
2005-2009
Exploiting noble-metal-free systems for high-performance photocatalytic CO2 reduction still presents a key challenge, partially due to the long-standing difficulties in developing potent and durable earth-abundant photosensitizers. Therefore, based on very cheap aluminum metal, we have deployed systematic series of homoleptic Al(III) photosensitizers featuring 2-pyridylpyrrolide ligands photoreduction. The combined studies steady-state time-resolved spectroscopy as well quantum chemical...
Biofilms often engender persistent infections, heightened antibiotic resistance, and the recurrence of infections. Therefor, infections related to bacterial biofilms are chronic pose challenges in terms treatment. The main transcription regulatory factor, CsgD, activates csgABC-encoded curli participate composition extracellular matrix, which is an important skeleton for biofilm development enterobacteriaceae. In our previous study, a wide range natural bioactive compounds that exhibit...
While the skin microbiome has been shown to play important roles in health and disease several species, effects of altitude on how high-altitude microbiomes may be associated with states remains largely unknown. Using 16S rRNA marker gene sequencing, we characterized people from two racial groups (the Tibetans Hans) three local pig breeds (Tibetan pig, Rongchang Qingyu pig) at high low altitudes. The microbial communities low-altitude pigs humans were distinct those humans, five bacterial...
Aim: The objective of this study is to develop a serovar-specific loop-mediated isothermal amplification (LAMP) method for sensitive, rapid, and inexpensive detection Salmonella serovar Enteritidis under field conditions. Methods: A set six specific primers was designed with DNA as the target. LAMP conditions were optimized by incubating target Bst polymerase large fragment in simple water bath. sensitivity specificity then compared those fluorescent quantitative real-time chain reaction...
Purpose: Leucine activates SIRT1/AMP-activated protein kinase (AMPK) signaling and markedly potentiates the effects of other sirtuin AMPK activators on insulin lipid metabolism. Phosphodiesterase 5 inhibition increases nitric oxide–cGMP signaling, which in turn exhibits a positive feedback loop with both SIRT1 AMPK, thus amplifying peroxisome proliferator-activated receptor γ co-activator α (PGC1α)-mediated effects. Methods: We evaluated potential synergy between leucine PDE5i sensitivity...
A series of indium( iii ) photosensitizers are used in photoinduced electron transfer reactions.
Abstract Background Goose parvovirus (GPV) is a Dependovirus associated with latent infection and mortality in geese. Currently, worldwide scale, GPV severely affects geese production. The objective of this study to develop loop-mediated isothermal amplification (LAMP) method for the sensitive, rapid, inexpensive detection field. Results A set six specific primers was designed by targeting VP3 DNA. With Bst DNA polymerase large fragment, target could be amplified at 65°C as early 20 min...
Pseudomonas aeruginosa (P. aeruginosa) is a known bacterium that produces biofilms and causes severe infection. Furthermore, P. are extremely difficult to eradicate, leading the development of chronic antibiotic-resistant infections. Our previous study showed cathelicidin-related antimicrobial peptide (CRAMP) inhibits formation markedly reduces biomass preformed biofilms, while mechanism eradicating bacterial remains elusive. Therefore, in this study, potential by which CRAMP eradicates was...
Sirt1, AMPK, and eNOS modulate hepatic energy metabolism inflammation are key players in the development of NASH. L-leucine, an allosteric Sirt1 activator, synergizes with low doses metformin or sildenafil on AMPK-eNOS-Sirt1 pathway to reverse mild NAFLD preclinical mouse models. Here we tested a possible multicomponent synergy yield greater therapeutic efficacy NAFLD/NASH. Liver cells macrophages atherogenic diet induced NASH model was treated two-way three-way combinations. The combination...
Despite significant economic and public health implications, swine enteric viruses that do not manifest clinical symptoms are often overlooked, data on their epidemiology pathogenesis still scarce. Here, an epidemiological study was carried out by using reverse transcription-polymerase chain reaction (RT-PCR) sequence analysis in order to better understand the distribution genetic diversity of porcine astrovirus (PAstV), encephalomyocarditis virus (EMCV), kobuvirus (PKV), sapovirus (PSaV)...
Beige adipocytes have become a promising therapeutic target to combat obesity. Our senior author Dr. B. Xue previously discovered transient but significant induction of beige in mice during early postnatal development, which peaked at day (P) 20 and then disappeared thereafter. However, the physiological mechanism underlying developmental cells remains mystery. Interestingly, there exists surge leptin P10 before appearance adipocytes. Given neurotropic effect neuronal development its role...
Swine viruses like porcine sapovirus (SaV), encephalomyocarditis virus (EMCV), rotavirus A (RVA) and astroviruses (AstV) are potentially zoonotic or suspected of potential zoonosis. These have been detected in pigs with without clinical signs often occur as coinfections. Despite the public health risks, no assay for detecting them all at once has developed. Hence, this study, a multiplex RT-PCR (mRT-PCR) was developed simultaneous detection SaV, EMCV, RVA AstV from swine fecal samples. The...
To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize series of novel pleuromutilin derivatives containing cinnamic acid scaffold at C-14 side chain. We evaluated their antibacterial activity and in silico docking study binding mode with target. The structure-activity relationship (SAR) suggested that compounds NO2 (13e), OH (13u), NH2 (13y) appeared more active (0.0625-2 µg/mL) vitro against several penicillin-resistant Gram-positive...
To investigate the distribution and genetic variation in four vertically transmitted duck pathogens, including hepatitis B virus (DHBV), circovirus (DuCV), A 3 (DHAV-3), avian reoviruses (ARV), we conducted an epidemiology study using PCR RT-PCR assays on a population. We found that DHBV was most prevalent (69.74%), followed by DuCV (39.48%), then ARV (19.92%) DHAV-3 (8.49%). Among 271 samples, two, three or viruses were detected same indicating coinfection of vertical transmission agents is...
Trueperella pyogenes is a significant pathogen of livestock, causing diverse diseases, such as mastitis, liver abscessation, and pneumonia. In this study, we have reported the genome sequence 2012CQ-ZSH. Moreover, several genes coding for virulence factors were found, pyolysin (PYO), nanH, nanP, cbpA, fimC, fimE.
Enterovirus G is a species of positive-sense single-stranded RNA viruses associated with several mammalian diseases. The porcine enterovirus strains isolated here were chimeric the PLCP gene torovirus, which grouped together global EV-G1 strains. EV-G strain could infect various cell types from different species, suggesting its potential cross-species infection risk. Animal experiment showed pathogenic ability to piglets. Additionally, EV-Gs widely distributed in swine herds. Our findings...
In this work, we report on a theoretical, computational, and experimental approach for evaluating dual-vacancies in (halo-)oxide systems focusing application to vacancy defects variety of apatite structures, i.e., structures the form A10(BO4)6X2 (A = Ca/Sr/Ba/La; B P/Si; X F/Cl/Br/O), which are prepared via solid-state reaction. Anion (particularly, oxygen, VO) often intentionally introduced through varying atmospheric conditions design inorganic multifunctional materials, work demonstrates...