A5071556472- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Renin-Angiotensin System Studies
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- NF-κB Signaling Pathways
- Heat shock proteins research
- Cancer, Lipids, and Metabolism
- Acute Lymphoblastic Leukemia research
- Chemokine receptors and signaling
- PI3K/AKT/mTOR signaling in cancer
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2025
Zhengzhou University
2022-2025
Henan Provincial Center for Disease Control and Prevention
2025
Hebei Medical University
2024
Jiangxi University of Traditional Chinese Medicine
2022-2024
Central Hospital of Zibo
2017-2024
Zhejiang University of Technology
2016-2024
Third Hospital of Hebei Medical University
2024
Hangzhou Xixi hospital
2023-2024
Zhejiang Chinese Medical University
2024
Deoxynivalenol (DON), a mycotoxin that contaminates crops such as wheat and corn, can cause severe acute or chronic injury when ingested by animals humans. This study investigated the protective effect of ferulic acid (FA), polyphenolic substance, on alleviating toxicity induced DON (40 μM) in IPEC-J2 cells. The experiments results showed FA not only alleviated decrease cell viability caused (p < 0.05), but increased level superoxide dismutase (SOD) 0.01), glutathione peroxidase (GSH-Px),...
Abstract Insufficient oxygen supply and elevated levels of reactive species (ROS) in rheumatoid arthritis (RA) joints synergistically exacerbate inflammation accelerate disease progression. In this study, a hybrid nanoassembly composed superoxide dismutase (SOD) catalase (CAT) conjugated within single poly(ε‐caprolactone) (PCL) nanoparticle is developed for RA therapy. The synthesized (PSC) drives proximity‐dependent cascade reaction that efficiently scavenges ROS generates oxygen, thereby...
Deoxynivalenol (DON) is a mycotoxin secreted by Fusarium species, posing great harm to food safety and human health. Therefore, it of significance study its toxic effects mechanism. miR-34a representative biomarker during the process DON-induced apoptosis. Herein, DON-triggered dual-color composite probe was constructed for simultaneous imaging DON in living cells. The aptamer blocks recognition sequence realize cell imaging. specific binding with HCR induced resulted recovery fluorescence...
Triple-negative breast cancer (TNBC) is characterized by high mortality rates, primarily due to its propensity for metastasis. Addressing this challenge necessitates the development of effective antimetastatic therapies. This study aimed identify natural compounds with potential properties mainly based on high-throughput phenotypic screening system. system, utilizing luciferase reporter gene assays combined scratch wound assays, evaluates their influence epithelial-mesenchymal transition...
AbstractNeutrophil extracellular traps (NETs) play a crucial role in breast cancer metastasis. However, the therapeutic target of NETs metastasis is still unknown. Using natural metabolite library and single-cell sequencing data analysis, we identified resveratrol (RES), polyphenolic phytoalexin, agonist silent information regulator-1 (SIRT1) that suppressed formation after cathepsin C (CTSC) treatment. In vivo, RES significantly hindered murine orthotopic 4T1 model. Serum levels...
The Uygur herb, Hyssopus officinalis L., has been demonstrated to affect the levels of a number cytokines in asthmatic mice, including interleukin-4, -6 and -17 interferon-γ. In present study, effect L. on airway immune regulation inflammation was investigated mouse model chronic asthma. A total 32 BALB/c mice were randomly divided into four groups, which included normal, asthmatic, dexamethasone treatment L.treatment groups. Mice sensitized challenged with ovalbumin establish an asthma...
The aim of the present study was to investigate inhibitory effect curcumin on tumor necrosis factor (TNF)-α-induced cell migration and matrix metalloproteinase (MMP)-2 expression activity in rat vascular smooth muscle cells (VSMCs), order identify whether effects are mediated by nuclear (NF)-κB signaling pathway. VSMCs were pretreated with prior stimulation TNF-α. Reverse transcription-polymerase chain reaction western blot analysis used determine MMP-2 mRNA protein levels TNF-α-stimulated...
It has been proved that Uygur herb Hyssopus offcinalis L. could affect the levels of some cytokines (such as IL-4, IL-6, IL-17, and IFN-γ) in asthmatic mice. By detection expressions MMP-9 TIMP-1 morphological changes, aim this research is to reveal mechanism process airway remodeling. was observed increased, but ratio MMP-9/TIMP-1 decreased remodeling group. However, expression both after being treated with dexamethasone L., accompanied by relieved pathological including collagen...
Beige adipocytes have become a promising therapeutic target to combat obesity. Our senior author Dr. B. Xue previously discovered transient but significant induction of beige in mice during early postnatal development, which peaked at day (P) 20 and then disappeared thereafter. However, the physiological mechanism underlying developmental cells remains mystery. Interestingly, there exists surge leptin P10 before appearance adipocytes. Given neurotropic effect neuronal development its role...
The mixed lineage kinase domain‑like protein (MLKL), which is a major mediator of the necroptosis pathway, involved in certain cancers. present study aimed to explore expression patterns and exact role MLKL gastric cancer (GC) tumorigenesis progression. In Cancer Cell Line Encyclopedia analysis, mRNA levels GC cell lines were not higher compared with that other lines. results demonstrated was decreased tissues normal tissues. Kaplan‑Meier Plotter database survival analyses, associated poor...
Abstract Background β‐elemene is known to play a critical role in tumorigenesis as well tyrosine kinase inhibitor (TKI) resistance lung cancer. However, the biological function and molecular mechanism remain largely unknown. Methods In this study, common genes involved gefitinib were identified using bioinformatic analysis. The expression of FBP1 was examined by qRT–PCR Western blot Cell proliferation, flow cytometry, clone formation IC50 assays performed assess effects FBP1. analysis used...
Hypoxic pulmonary hypertension (HPH) may contribute to vascular remodeling, and artery smooth muscle cell (PASMC) proliferation has an important role in this process. However, no relevant information concerning the mechanism of protein kinase C (PKC)α hypoxia‑induced rat PASMC been elucidated. The present study aimed further investigate by comparison among normoxia for 72 h (21% O2), hypoxia (3% + promoter 12‑myristate 13‑acetate control, safingol PD98059 control U0126 groups. demonstrated...