Aims Ischemic preconditioning (IPC) is a potent form of endogenous protection. However, IPC-induced cardioprotective effect significantly blunted in insulin resistance-related diseases and the underlying mechanism unclear. This study aimed to determine role glucose metabolism IPC-reduced reperfusion injury. Methods Normal or streptozotocin (STZ)-treated diabetic rats subjected 2 cycles 5 min ischemia/5 prior myocardial ischemia (30 min)/reperfusion (3 h). Myocardial uptake was determined by...

Our study is the first to report an especially high rate of grade 2 or worse radiation pneumonitis in patients treated with thoracic radiotherapy and simultaneous Osimertinib, despite total lung V5, V20 MLD seeming unlikely induce pneumonitis.

Abstract In this work, technetium-99 ( 99m Tc) was used as the radiolabeling isotope to study biodistribution of oxidized multi-walled carbon nanotubes (oMWCNTs) and/or nanodiamonds (NDs) in mice after intravenous administration. The histological impact non-radiolabeled oMWCNTs or NDs investigated comparison co-exposure groups. Tc-labeled nanomaterials had high stability vivo and fast clearance from blood . After a single injection oMWCNTs, highest distribution found lungs, with lower uptake...

The adsorption of Cu(II) on oxidized multi-walled carbon nanotubes (oMWCNTs) as a function contact time, pH, ionic strength, temperature, and hydroxylated fullerene (C60(OH)n) carboxylated (C60(C(COOH)2)n) were studied under ambient conditions using batch techniques. results showed that the had rapidly reached equilibrium kinetic process was well described by pseudo-second-order rate model. oMWCNTs dependent pH but independent strength. Compared with Freundlich model, Langmuir model more...

Abstract Hypertension is a major risk factor for cardiovascular and cerebrovascular disease. Prenatal exposure to lipopolysaccharide (LPS) leads hypertension in rat offspring. However, the mechanism still unclear. This study unraveled epigenetic this explored protective effects of ascorbic acid against on prenatal inflammation-induced LPS resulted an increase intrarenal oxidative stress enhanced angiotensin-converting enzyme 1 ( ACE1 ) gene expression at mRNA protein levels 6- 12-week-old...

Bioactive peptides display a number of favorable features as therapeutics, but their usage is challenging due to the low metabolic stability and rapid renal clearance. The small-molecule protractor, which functions by noncovalent binding with serum albumin protection against systemic clearance, an attractive tool elongate peptides' half-life. Herein, we investigated coomassie brilliant blue (CBB) new protractor for half-life extension clinically relevant glucagon-like peptide 1 (GLP-1). A...

To investigate the effect of ILC2s on Th2-type adaptive immunity during acute exacerbation chronic obstructive pulmonary disease (AECOPD), study enrolled healthy people, stable COPD patients, and AECOPD patients. Flow cytometry was used to detect Th1, Th2, ILC2 in peripheral blood CD80 MHC II levels ILC2. The mRNA GATA3 , RORα CRTH2 were detected by RT-PCR. In addition, from patients cocultured with CD4 + T cells controls. Cytokine serum three groups vitro coculture supernatants measured...

It has been proved that Uygur herb Hyssopus offcinalis L. could affect the levels of some cytokines (such as IL-4, IL-6, IL-17, and IFN-γ) in asthmatic mice. By detection expressions MMP-9 TIMP-1 morphological changes, aim this research is to reveal mechanism process airway remodeling. was observed increased, but ratio MMP-9/TIMP-1 decreased remodeling group. However, expression both after being treated with dexamethasone L., accompanied by relieved pathological including collagen...

This study aimed to investigate the beneficial effect of baicalin-zinc complex (BZN) on intestinal microorganisms in deoxynivalenol (DON)-challenged piglets and association between host immunity hormone secretion. Forty weaned were randomly divided into four treatments with 10 each treatment: (1) control (Con) group (pigs fed basal diet); (2) DON 4 mg DON/kg (3) BZN 0.5% (4) DBZN diet). The experiment lasted for 14 days. supplementation DON-contaminated diets changed microbiota composition...

Prenatal exposure to inflammation results in hypertension during adulthood but the mechanisms are not well understood. Maternal lipopolysaccharide (LPS) alters interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels fetal environment. As reported many recent studies, IL-6 regulates DNA methyltransferases (DNMTs) through transcription factor friend leukemia virus integration 1 (Fli-1). The present study explores role of intrarenal DNMTs development induced by prenatal LPS. Pregnant...

It is important to distinguish those with active Mycobacterium tuberculosis infection (ATB) from latent (LTBI) for monitoring and treating the disease. Monocytes play an role may undergo morphological changes against TB infection. The aim of this study investigate clinical usefulness monocyte morphometric parameters chemoattractant protein-1 (MCP-1) healthy controls (HC).Peripheral blood was collected 97 ATB patients, 113 LTBI 101 controls. were obtained using a UniCel Coulter DxH800 system....

Background: Despite great effort to control tuberculosis (TB), low treatment adherence threatens the success of drug therapy, increases risk TB transmission, and leads development resistance.

Chemotherapy has been successfully used to reduce radiation dose and volume for most pediatric patients. However, because of the failure chemotherapeutic agents cross blood-brain barrier lack response some brain tumors these agents, therapy is still treat many childhood cancers with CNS involvement. In this study, we investigated effects on cognition dendritic structure in hippocampus juvenile male mice. Twenty-one-day-old C57BL/6 mice were irradiated using small animal research platform...

Abstract The aim of this work was to explore whether bisoprolol plays a protective role in cardiomyocytes against ischemia–reperfusion injury via PI3K/AKT/ GSK3β pathway. We pretreated male Sprague Dawley (SD) rats with by oral administration prior 0.5 h ischemia/4 reperfusion. Myocardial infarct size and serum levels cTnI CK‐MB were measured. In vitro, H9c2 cells treated hypoxia reoxygenation, followed measurement cell viability, apoptosis, ROS production, cytometry, activities AKT, GSK3β,...

Measurement of fractional exhaled nitric oxide (FeNO) is a quantitative and non-invasive approach to examine airway inflammation, which powerful aid in diagnosing chronic disorders airways like asthma. Diagnostic value FeNO relevant indices on pulmonary function the patients with asthma obstructive disease (COPD) was evaluated. A total 164 [58 asthma, 49 COPD 57 asthma‑COPD overlap (ACO)] were randomly recruited. FeNO, ventilation function, bronchial diastolic performed. Eight indicators...

Objective. In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold‐dryness syndrome (CDSCOPD) relieve cough and sputum. However, underlying mechanisms of MZP on treating CDSCOPD remain be elucidated. Methods . rat models were established; was given rats in last 7 days 97‐day model establishment. Then subjected lung function measurement. Pathological changes lungs observed through paraffin section H&E staining. The mRNA protein levels...

Objective. To investigate the effect of abnormal savda munziq (ASM) on pulmonary function and expression lung-specific aquaporins in rat model chronic obstructive disease with syndrome (ASSCOPD). Methods. Eighty male rats were randomized into ASSCOPD, COPD, control groups. ASSCOPD was further categorized ASM non-ASM COPD established by combining fumigation airway instillation elastase; developed based induction dry cold diet, environment, plantar electric stimulation. administered twice...

Brucellar spondylitis (BS) is one of the most serious complications brucellosis. CXCR3 closely related to severity disease infection. This research aimed study degree BS inflammatory damage through analyzing expression levels and its ligands (CXCL9 CXCL10) in patients with BS.A total 29 15 healthy controls were enrolled. Real-Time PCR was used detect mRNA IFN-γ, CXCR3, CXCL9 CXCL10 peripheral blood mononuclear cells (PBMCs) controls. Hematoxylin-Eosin staining show pathological changes...