A5004765969- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Histone Deacetylase Inhibitors Research
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- HIV/AIDS drug development and treatment
- Multiple Myeloma Research and Treatments
- Alcohol Consumption and Health Effects
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- RNA modifications and cancer
Shanghai East Hospital
2024-2025
Shanghai Jiao Tong University
2022-2023
Tongji University
2023
Ruijin Hospital
2022
Cuproptosis is a newly discovered copper-independent cell death modality, and limited evidence suggests the critical implications in human cancers. Nonetheless, clinical impacts of cuproptosis-relevant lncRNAs lung adenocarcinoma (LUAD) remain largely ill-defined. The present study was aimed at defining lncRNA signature for LUAD discuss utility.We collected transcriptome expression profiling, information, somatic mutation, copy number variations from TCGA-LUAD cohort retrospectively. genetic...
Abstract Background Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this study aimed to elucidate function ENO1 MM, particularly impact on mitophagy under bortezomib-induced apoptosis. Methods The bone marrow clinical MM patients and healthy normal donors was used compare expression level ENO1. Using online databases, we conducted an analysis...
AbstractNeutrophil extracellular traps (NETs) play a crucial role in breast cancer metastasis. However, the therapeutic target of NETs metastasis is still unknown. Using natural metabolite library and single-cell sequencing data analysis, we identified resveratrol (RES), polyphenolic phytoalexin, agonist silent information regulator-1 (SIRT1) that suppressed formation after cathepsin C (CTSC) treatment. In vivo, RES significantly hindered murine orthotopic 4T1 model. Serum levels...
Epigenetic modifications play an important role in cellular senescence, and enhancer of zeste homolog 2 (EZH2) is a key methyltransferase involved epigenetic remodeling multiple myeloma (MM) cells. We have previously demonstrated that GSK126, specific EZH2 inhibitor, exhibits anti-MM therapeutic efficacy safety
Chemoresistance is an important factor in multiple myeloma (MM) relapse and overall survival. However, the mechanism underlying resistance remains unclear. In this study, we identified adenine nucleotide translocase 3 (ANT3) as a novel biomarker therapeutic target for MM progression to proteasome inhibitor bortezomib (BTZ). The oncogenic functions of ANT3 were verified using sensitive/drug-resistant cells, bone marrow tissues from patients with MM, orthotopic model, subcutaneous tumor model....