A5069724960- Epigenetics and DNA Methylation
- Marine Invertebrate Physiology and Ecology
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Venomous Animal Envenomation and Studies
- Ferroptosis and cancer prognosis
- Spinal Fractures and Fixation Techniques
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- RNA Research and Splicing
- Spine and Intervertebral Disc Pathology
- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Pelvic and Acetabular Injuries
- Marine Sponges and Natural Products
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Immune Cell Function and Interaction
- Intravenous Infusion Technology and Safety
Shanghai East Hospital
2013-2025
Hebei Medical University
2024-2025
Fourth Hospital of Hebei Medical University
2024-2025
Emory University
2020-2025
Tongji University
2012-2024
Henan Provincial People's Hospital
2020-2024
Shanghai University of Traditional Chinese Medicine
2024
Fujian Medical University
2022
Shanghai Tenth People's Hospital
2016-2022
University of Chinese Academy of Sciences
2022
Reprogramming of NK cells with a chimeric antigen receptor (CAR) proved an effective strategy to increase cell reactivity and recognition specificity toward tumor cells. To enhance the cytotoxicity against CD138‐positive multiple myeloma (MM) cells, we generated genetically modified NK‐92MI carrying CAR that consists anti‐CD138 single‐chain variable fragment (scFv) fused CD3ζ chain as signaling moiety. The genetic modification through lentiviral vector did not affect intrinsic cytolytic...
Abstract Background Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this study aimed to elucidate function ENO1 MM, particularly impact on mitophagy under bortezomib-induced apoptosis. Methods The bone marrow clinical MM patients and healthy normal donors was used compare expression level ENO1. Using online databases, we conducted an analysis...
Colorectal cancer (CRC) presents a complex tumor microenvironment influenced by genetic and microbial factors. Microbial DNA from the gut can translocate into bloodstream, forming circulating microbiome associated with prognosis clinicopathological features. This study investigates peripheral venous blood in CRC patients using 2bRAD-M sequencing evaluates its clinical significance. Peripheral samples 29 (19 males, 10 females; mean age 57 years) healthy controls were analyzed to assess...
Abstract Cancer stem cells (CSCs) are the main cause of tumor development, metastasis, and relapse. CSCs thus considered promising targets for cancer therapy. However, it is hard to eradicate due their inherent plasticity heterogeneity, underlying mechanism switch between non‐CSCs remains unclear. Here, shown that miR‐135a combined with SMYD4 activates Nanog expression induces into CSCs. The level, once elevated, lowers methylation level CG5 site in promoter by directly targeting DNMT1....
Abstract Triple‐negative breast cancer (TNBC) is a highly heterogeneous disease. The aim of this study to identify the diagnostic and poor prognostic signatures in TNBC by exploring aberrant DNA methylation gene expression. Differential expression analysis paracancer samples from Cancer Genome Atlas were performed. Gene set enrichment protein–protein interaction (PPI) network was used explore mechanisms TNBC. Methylation‐gene correlation performed, multivariate Cox receiver operating...
The purpose of this study is to determine the relationship between methylation and loss hMLH1 hMSH2 expression in ovarian cancer.We examined status promoter region by methylation-specific polymerase chain reaction (MSP) 56 primary cancer tissues 20 normal tissues, these two genes clinicopathological characteristics were analysed. We then treated SKOV3 3AO cell lines with demethylating agent 5-aza-2'-deoxycytidine (5-aza-dc). was further assessed MSP, their mRNA compared reverse transcription...
The abnormally activated hedgehog (Hh) signaling pathway is involved in the regulation of proliferation and apoptosis pancreatic cancer cells, while its exact molecular mechanism not clear. purpose this study was to investigate regulatory effect Hh on transcription BIRC3 gene underlying as well relationship between Gli1-dependent cell survival. Firstly, we examined knockdown or overexpression messenger RNA (mRNA) expression by real-time RT-PCR. Then, Gli1 investigated XChIP-PCR luciferase...
Abstract Background Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these could be therapeutically exploited. Ribonucleotide reductase (RNR) is rate-limiting enzyme for biosynthesis deoxyribonucleotides (dNTPs), which are essential replication damage repair. In this study, we explored efficacy novel RNR inhibitor, 4-hydroxysalicylanilide (HDS), cells xenograft model....
More and more studies show that chronic inflammation can lead to tumor formation. The complex interactions of inflammatory cells, stroma parenchymal cell are closely related Under the state microenvironment, long-term interaction cells stromal as well makes signaling pathway in parenchyma disordered. A series gene level editor modification, epigenetic changes, regulation transcription translation changes will happen based on disorder. ultimately mutations phenotypic transformation occurred....
Alzheimer’s disease (AD) is the most common neurodegenerative among elderly and has become a growing global health problem causing great concern. However, pathogenesis of AD unclear no specific therapeutics are available to provide sustained remission disease. In this study, we used comprehensive bioinformatics determine 158 potential genes, whose expression levels changed between entorhinal temporal lobe cortex samples from cognitively normal individuals patients with AD. Then, clustered...
Dear Editor, Bladder cancer (BCa) is a common malignant tumor in the genitourinary system. Approximately 20-25% of BCa muscle-invasive bladder (MIBC), and MIBC prone to progression metastasis.1 Radical cystectomy (RC) combined with lymphadenectomy currently most effective treatment for MIBC, which can maximize patients survival time.2 However, RC partly damages intestinal function affects metabolism. Studies have shown that lead 5% weight loss 7-17% muscle mass 2 weeks after operation.3 In...
Purpose: To measure the projection of most anterior line spinal canal on lateral radiographs vertebra (C3–L5) and evaluate efficacy safety (SL) in preventing intraspinal cement leakage percutaneous kyphoplasty (PKP) vertebroplasty (PVP). Materials Methods: Fifteen adult dry-bone spine specimens were analyzed. The SL was viewed radiographs. distance between posterior vertebral body (PVBL) measured. Two groups patients treated by PKP, injection stopped either before PBVL (group 1) or 2) under...
BACKGROUND:Primary liver cancer is a common malignant tumor that causes serious damage to human health. DNA methylation in epigenetics. plays an important role the process of primary occurrence and development. The P14ARF gene suppressor gene. It was found associated with degree malignancy multiple tumors. Therefore, this study aimed investigate relationship between level degree. MATERIAL AND METHODS:Carcinoma tissues adjacent were collected from 87 patients. Pyrosequencing applied obtain...
To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination is reported to distinguish individuals with early-stage HCC from at-risk individuals.Participants in this study were recruited six hospitals China. Literature review was used choose 19 candidate proteins, a case-control discovery stage identify five proteins (P5) that constituted model. In training and validation stages, effectiveness P5 for detecting tested...
Abstract Background DCZ3301, a novel aryl-guanidino compound previously reported by our group, exerts cytotoxic effects against multiple myeloma (MM), diffused large B cell lymphoma (DLBCL), and T-cell leukemia/lymphoma. However, the underlying mechanism of its action remains unknown. Methods We generated bortezomib (BTZ)-resistant lines, treated them with various concentrations DCZ3301 over varying periods, studied effect on colony formation, proliferation, apoptosis, cycle, DNA synthesis,...
Hepatocellular carcinoma (HCC) has a high rate of postoperative recurrence and lacks an effective treatment to prevent recurrence. This study aims investigate the efficacy safety anlotinib in adjuvant therapy for HCC patients with high-risk factors.For this multicenter, retrospective study, we recruited 63 who received either (n=27) or transcatheter arterial chemoembolization (TACE) (n=36) from six research centers China between March 2019 October 2020. The primary endpoint was disease-free...
Patients with intact immunoglobulin (Ig) multiple myeloma (MM) usually show parallel fluctuations of their Ig and light chain (LC) concentrations. Herein we report 11 patients relapsed, MM a marked increase in urinary LCs the absence rise serum Ig, known as escape (LCE). A major feature accompanying presentation LCE was conversion plasma cell morphology. An important preceding onset use biological therapies. These were not associated highly aggressive course. Median overall survival times...
The purpose of our study was to evaluated the cost-effectiveness two bladder cancer (BCa) urinary diversions: Studer and Bricker.The included 44 patients with 40 Bricker. Collected analyzed patient's basic characteristics, health care costs, prognosis survival. quality-adjusted life-year (QALY) were calculated verified by European Organization for Research Treatment Cancer Quality Life Questionnaire Core-30 (EORTC QLQ-C30, Version 3, Chinese version). Cost-effectiveness depends on...