A5004139328- Urban Heat Island Mitigation
- Environmental Impact and Sustainability
- Computational Drug Discovery Methods
- Ion Transport and Channel Regulation
- Potato Plant Research
- Metabolomics and Mass Spectrometry Studies
- Building Energy and Comfort Optimization
- Traditional Chinese Medicine Studies
- Osteoarthritis Treatment and Mechanisms
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Sphingolipid Metabolism and Signaling
Shanghai Tenth People's Hospital
2021-2024
Tongji University
2020-2024
Abstract This research was to reveal the key factors in progression of osteoarthritis (OA) using non-targeted metabolomics and find targeted therapies for patients with OA. Twenty-two knee OA scheduled total arthroplasty were divided into two groups: Kellgren–Lawrence (KL) grade 3 ( n = 16) 4 6), according plain X-rays knee. After operation, cartilages femur samples analyzed metabolomics. When compared patients, levels choline, 2-propylpiperidine, rhamnose, monomethyl glutaric acid higher;...
Alzheimer’s disease (AD) is the most common neurodegenerative among elderly and has become a growing global health problem causing great concern. However, pathogenesis of AD unclear no specific therapeutics are available to provide sustained remission disease. In this study, we used comprehensive bioinformatics determine 158 potential genes, whose expression levels changed between entorhinal temporal lobe cortex samples from cognitively normal individuals patients with AD. Then, clustered...
Acidosis is a hallmark of ischemic stroke and promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically alleviate the volume brain infarct restore neurological function after cerebral ischemia. However, few pharmacological candidates have been identified to exhibit efficacy on through inhibition ASIC1a. In this work, we examined ability toxin-inspired...