A5041942629- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Intensive Care Unit Cognitive Disorders
- Medical Research and Treatments
- Metabolism and Genetic Disorders
- Health, psychology, and well-being
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Cardiac Ischemia and Reperfusion
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Healthcare Education and Workforce Issues
- Parasites and Host Interactions
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- Clinical Nutrition and Gastroenterology
- Traditional Chinese Medicine Studies
- Phosphodiesterase function and regulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolomics and Mass Spectrometry Studies
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
Nanjing University
2007-2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
NARI Group (China)
2023
Zhejiang University Medical College Affiliated Stomatological Hospital
2023
South China University of Technology
2023
Guangzhou Medical University
2023
Guangzhou First People's Hospital
2023
Guangxi Center for Disease Prevention and Control
2021
Nanjing Normal University
2021
Abstract This research was to reveal the key factors in progression of osteoarthritis (OA) using non-targeted metabolomics and find targeted therapies for patients with OA. Twenty-two knee OA scheduled total arthroplasty were divided into two groups: Kellgren–Lawrence (KL) grade 3 ( n = 16) 4 6), according plain X-rays knee. After operation, cartilages femur samples analyzed metabolomics. When compared patients, levels choline, 2-propylpiperidine, rhamnose, monomethyl glutaric acid higher;...
This finite element analysis aimed to examine the effect of medial cortical support and screw on loads at implant-bone interface locking plate fixation proximal humeral fractures with a gap.An intact humerus from healthy volunteer was used as basis for 3-dimensional (3D) computer-aided design (CAD) model. The 3D CAD model system based information in manufacturer's catalogue. part osteotomized create standard three-part fractures, which were then divided into -MSC group (which lacked support,...
In Brief BACKGROUND: Intravascular volume therapy is crucial in septic patients to improve tissue perfusion and maintain stable hemodynamics. Modified fluid gelatins (MFG) medium weight hydroxyethyl starches (HES) are the most widely used synthetic colloids. Our aim this study, performed rats challenged by cecal ligation puncture (CLP), was investigate effects of HES MFG on pulmonary capillary leakage determine whether an antiinflammatory mechanism involved. METHODS: Animals were randomly...
We classified 50 receptor units from 10 acupoints supplied by the medium nerve. It was found that needling stimulation mostly excited slowly adapting receptors and classification of acupoint related closely to their location. For example, Shanyang, Zhongchong, Shaoshang in skin sensation are touch or pressure units; Neiguan, Yuji, etc.; located deep tissue with abundant muscles, muscle spindles; Daling might be a colgi tendon and/or unit. Besides significant receptor, an contains one more...
The molecular mechanisms underlying neuropathic pain have yet to be elucidated. present study aimed examine the modulation of neuroimmune activation in spinal cord by synthetic peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, pioglitazone (Pio), a rat model induced chronic constriction injury (CCI). Rats were randomly assigned into four groups: Sham surgery with vehicle, vehicle or Pio (10 mg/kg), and PPAR-γ antagonist GW9662 (2 mg/kg). was administered 1 h prior continued...
Recent studies have characterized a central nervous system neuroimmune effect in the analgesic mechanisms of antidepressants. Our study investigated novel antidepressant mirtazapine on pro-inflammatory cytokines expression and astrocytic activation hippocampus neuropathic rats. L5 spinal nerve transection was made to produce mononeuropathic model. Mirtazapine orally administered rats that had been operated daily for 14 days. Adrenergic or serotonergic receptor antagonist intraperitoneally...
Acute graft rejection is one of the most common and serious post complications in renal transplantation, noninvasive diagnosis acute essential for reducing risk surgery timely treatment. In this study, a non-targeted metabonomics approach based on ultra performance liquid chromatography (UPLC) coupled with quadrupole time-of-flight mass spectrometry (MS) used to investigate effect rat transplantation metabolism. To collect more metabolite information both hydrophilic interaction...
Abstract Previous studies have demonstrated that sevoflurane could attenuate cerebral neuron necrosis and apoptosis in ischemia–reperfusion models rats. The aim of our study was to investigate the effect preconditioning with on spatial learning memory ability after focal injury rats its potential mechanisms. Focal ischemia performed via 1 h middle artery occlusion (MCAO) followed by reperfusion. Before ischemia, were subjected inhalation 2.4% for h. measured Morris water maze. activity...
Abstract Background Soil-transmitted helminths (STHs), such as hookworm, roundworm and whipworm, food-borne trematodiases, including Clonorchis sinensis , remain a public health problem worldwide, especially in tropical subtropical regions. Objective We aimed to determine the current prevalence of these parasites Guangxi, China, which is located region. Methods A cross-sectional study 4-year longitudinal surveillance were carried out. Stool samples collected examined microscopically for...
Abstract Background At the onset of their professional journey, novice nurses often undergo a multifaceted psychological experience as they transition from theoretical knowledge to clinical practice, potentially impacting development identity. However, limited research has been conducted on aspects pertaining newly graduated in stomatological hospitals our country. Methods The phenomenological method and semi-structured interviews were used this study, sample size interview was purposive...
Phosphodiesterase 4 (PDE4) is an adenosine cyclic 3,5-monophosphate-specific degradative enzyme, which closely associated with the inflammatory response. Among its four subtypes (A‑D), it remains unclear one exerts suppressive effects on inflammation and reduces neuropathic pain. The present study aimed to examine modulation of neuroinflammation by PDE4 in spinal cord a rat model L5 nerve ligation (SNL)‑induced expression levels PDE4A‑D were measured lumbar cords naïve rats. rats then...
Alzheimer's disease (AD) and ischemic brain injury are two major neurodegenerative diseases. Mitochondrial dysfunction commonly occurs in AD injury. Currently, little attention has been paid to the glycans on mitochondrial glycoproteins, which may play vital roles during process of dysfunction. The aim this study was illustrate compare glycopattern alterations glycoproteins extracted from cerebral cortex rat models these diseases using High-throughput lectin microarrays. results shown that...