A5103083344- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Hematopoietic Stem Cell Transplantation
- Enhanced Recovery After Surgery
- Immune Cell Function and Interaction
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Botulinum Toxin and Related Neurological Disorders
- Phosphodiesterase function and regulation
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Hydrogen's biological and therapeutic effects
- Nerve injury and regeneration
- Acupuncture Treatment Research Studies
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Natural Compounds in Disease Treatment
- RNA Interference and Gene Delivery
- Inflammatory Bowel Disease
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
Nanjing University
2013-2024
Nanjing General Hospital of Nanjing Military Command
2011-2024
Jinling Institute of Technology
2004-2024
Collaborative Innovation Center of Advanced Microstructures
2024
Zhuzhou Central Hospital
2021-2023
Central South University
2021-2023
Nanjing Medical University
2017-2022
Institute of Hematology & Blood Diseases Hospital
2013-2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2016
Southwest Hospital
2011-2013
Small molecules that can selectively target cancer stem cells (CSCs) remain rare currently and exhibit no common structural features. Here we report a series of guaianolide sesquiterpene lactones (GSLs) their derivatives eradicate acute myelogenous leukemia (AML) or progenitor cells. Natural GSL compounds arglabin, an anticancer clinical drug, micheliolide (MCL), are able to reduce the proportion AML (CD34⁺CD38⁻) in primary Targeting is further confirmed by sharp reduction colony-forming...
Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process microglia polarization towards phenotype often occurs during neuroinflammation. Recent studies have demonstrated an active for gut microbiota promoting microglial full maturation inflammatory capabilities via production Short-Chain Fatty Acids (SCFAs). However, it remains unclear whether SCFAs is involved pro-inflammatory/anti-inflammatory phenotypes In present...
AKR1C2, also referred to as the human bile acid binder and 3α-hydroxysteroid dehydrogenase type III, is a multifunctional oxidoreductase able stereoselectively reduce steroids well oxidize or polyaromatic hydrocarbons. Previously, this same protein was identified by its robust induction phase II inducers in HT29 cells. In HepG2 cells, both <i>AKR1C2</i> <i>AKR1C1</i> (97% sequence homology) were induced but not highly related <i>AKR1C3</i> <i>AKR1C4</i> family members (84% homology). We now...
Among cyclin-dependent kinase inhibitors that control the G1 phase in cell cycle, only p18 and p27 can negatively regulate haematopoietic stem (HSC) self-renewal. In this manuscript, we demonstrate protein is a more potent inhibitor of HSC self-renewal than mouse models its deficiency promoted expansion long-term culture. Single-cell analysis indicated deleting gene favoured self-renewing division vitro. Based on structure in-silico screening, further identified novel small-molecule...
Organic photovoltaic (OPV) devices attain high performance with nonfullerene acceptors by utilizing the synergistic dual channels of charge generation that originate from excitations in both donor and acceptor materials. However, specific intermediate states facilitate are subject to debate. To address this issue, we employ time-resolved terahertz spectroscopy improved sensitivity (ΔE/E < 10–6), enabling direct probing dynamics a prototypical PM6:Y6 bulk heterojunction system under...
Although activation of astrocytes is critical in developing neuropathic pain (NP) following nerve injury, the underlying mechanisms NP and therapeutic management for are still vague. Importantly, decreases levels astrocytic glutamate transporter-1 (GLT-1) spinal dorsal horn result enhanced excitatory transmission cause persistent pain. P2Y1 purinergic receptor (P2Y1R) has been shown to enhance many inflammatory processes. The up-regulated expression P2Y1R crucial participate transduction...
The molecular mechanisms underlying neuropathic pain have yet to be elucidated. present study aimed examine the modulation of neuroimmune activation in spinal cord by synthetic peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, pioglitazone (Pio), a rat model induced chronic constriction injury (CCI). Rats were randomly assigned into four groups: Sham surgery with vehicle, vehicle or Pio (10 mg/kg), and PPAR-γ antagonist GW9662 (2 mg/kg). was administered 1 h prior continued...
Abstract Background An excessive postoperative inflammatory response is common after surgery for bowel disease (IBD) and may be associated with an increased incidence of ileus. This study assessed the role perioperative dexamethasone in ileus IBD surgery. Method Patients undergoing elective were randomized to either intravenous 8-mg dose (n = 151) or placebo upon induction anesthesia. The primary outcome was prolonged Secondary outcomes included reported nausea vomiting, time first passage...
Recent studies indicate the central neuroimmune and neuroinflammation activation play a critical role in pathological states of pain. Pioglitazone, potent synthetic agonists PPARgamma, has shown to control many nervous system-related disorders. The present study was designed explore effects pioglitazone treating neuropathic pain its possible mechanisms using lumbar 5 (L5) spinal nerve transection rat model. L5 done produce hyperalgesia rats. Pioglitazone (2.5, 5, 10 mg/kg) orally...
Abstract Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these ex vivo . Therefore, there an urgent need identify specific targets effective probes that can HSCs. Here we report a novel class of INK4C (p18 or p18) small molecule inhibitors (p18SMIs), which were initially found in silico 3D screening. We identified lead p18...
Previous studies have shown that the Wnt/β‐catenin signaling pathway plays an important role in modulating neuropathic pain after sciatic nerve injury. In this study, we explored of secreted frizzled‐related protein 1 (SFRP1), a Wnt antagonist, using mouse model following spinal ligation (SNL). We found SNL‐induced SFRP1 downregulation cord. Further, overexpression via injection into cord attenuated allodynia, hyperalgesia, and neuroinflammation. Consistently, vitro assays also showed...
The behaviors of free charge carriers and the crucial factor carrier diffusion length in perovskite films are intricately connected, with both time-resolved terahertz spectroscopy (TRTS) photoluminescence (TRPL) being viable techniques for investigation. Yet, consistency results these two methods provide regarding dynamics is still a matter debate. In this study, we scrutinize excited-state within MAPbI3 films, which were fabricated through three distinct methods, under equivalent excitation...