A5083824332- Hematopoietic Stem Cell Transplantation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Immune cells in cancer
- Digital Imaging for Blood Diseases
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Blood properties and coagulation
- Chronic Myeloid Leukemia Treatments
- Pancreatic function and diabetes
- Biosensors and Analytical Detection
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Ion Transport and Channel Regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
Institute of Hematology & Blood Diseases Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Southern University of Science and Technology
2021
Nankai University
2010
Diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) are subtypes of non-Hogkin (NHL) that generally distinct form one cases, but the transformation these diseases into other is possible. Some patients with CLL, for instance, have potential to develop Richter such they diagnosed a rare, invasive DLBCL subtype. In this study, bioinformatics analyses two NHL were conducted, identifying key patterns gene expression then experimentally validating results. Disease-related...
Transcription factor Twist-1 plays essential roles in specification and differentiation of mesoderm-derived tissues. Growing evidences now link to the acquisition stem-cell-like properties. However, role hematopoietic stem cell (HSC) remains largely uncharacterized. We report that is more highly expressed murine HSC its expression declines with differentiation. To investigate gene function, retroviral-mediated overexpression or removal experiments are performed. Competitive repopulation...
The development of early B cells, which are generated from hematopoietic stem cells (HSCs) in a series well-characterized stages bone marrow (BM), represents paradigm for terminal differentiation processes. Akt is primarily regulated by phosphorylation at Thr308 PDK1 and Ser473 mTORC2, signaling plays key role hematopoiesis. However, the mTORC2 remains poorly understood. In this study, we investigated functional specifically deleting an integral component, Rictor, system. We demonstrated...
Abstract Objectives In patients with essential thrombocythemia ( ET ), vascular complications contribute to both morbidity and mortality. To better predict the occurrence of thrombotic events, an International Prognostic Score thrombosis for IPSET ‐thrombosis) was recently developed. We hereby presented external validation analysis this model in a large Cohort Chinese Patients. Methods retrospectively evaluated characteristics risk factors 970 estimated clinical implications ‐thrombosis...
Objective: The issue of when to start treatment in patients with hyperuricemia (HUA) without gout and chronic kidney disease (CKD) is both important controversial. In this study, Raman spectroscopy (RS) was used analyze urine samples, key genes expressed differentially CKD were identified using bioinformatics. biological functions regulatory pathways these preliminarily analyzed, the relationship between them as well heterogeneity components HUA evaluated. This study provides new ideas for...
T-cell acute lymphoblastic leukemia (T - ALL)/T-cell lymphoma (T-LBL) is an uncommon but highly aggressive hematological malignancy. It has high recurrence and mortality rates challenging to treat. This study conducted bioinformatics analyses, compared genetic expression profiles of healthy controls with patients having T-ALL/T-LBL, verified the results through serological indicators. Data were acquired from GSE48558 dataset Gene Expression Omnibus (GEO). T-ALL normal T cells-related...
To clarify foam cell origination in atherosclerosis, a series of morphologic and ultrastructural alterations vascular smooth muscle cells (VSMCs) were studied by light electron microscopy atherosclerotic aortas from hyperlipidemic rabbits induced for 5 weeks. The study exhibited that VSMCs severely degenerated damaged, including irregular shapes, expanded mitochondria, aplenty lipid droplets, disarranged myofilaments cytoplasm media adjacent to atheromatic bottoms. Most laden shared...
The genome instability and tumorigenicity of induced pluripotent stem cells (iPSC) hinder their great potentials for clinical application. Using episomal vectors to generate iPSC is the best way solve safety issues at present. This method simple exogenous gene was not integrated into host genome. However, reprogramming efficiency this very low thus limits its usage. study purposed improve generating from cord blood mononuclear (CB MNC), establish integration-free technology system, lay...
Myeloid histocytes of dendritic cells (DCs), Langerhans (LCs), and macrophages in varied tissues, as leukemic blasts acute monoblastic monocytic leukemia (AML-M5a M5b), are derived from monocyte progenitors bone marrow. Based on DC induction hematopoietic stem cells, myeloid progenitors, monocytes, occasional expressions histocyte-related antigens (HRAs) M5, we presume some M5 cases share histiocytic phenotypes originally. To clarify the conception, 93 were tested with antibodies for HRAs,...
Background Mitochondria are mainly involved in ATP production to meet the energy demands of cells. Researchers increasingly recognizing important role mitochondria differentiation and activation hematopoietic cells, but research on how mitochondrial metabolism influence different subsets lymphocyte at stages yet be carried out. In this work, functions lymphocytes were compared included CD8 + T lymphocytes, CD4 B NK cells as well their subsets. For purpose, a complete set methods was used...
Hematopoietic microenvironments have been extensively studied, especially focusing on regulation of hematopoietic stem cells (HSCs) in HSC niche following progress molecular biology resent years. Based prior morphological achievements from 1970s, the characteristics cellular compartments and bone marrow stromal (BMSCs) were studied ultrastructurally human mice present study. The samples, granules, collected aspirations (BMAs) 20 patients with hematocytopenia isolated BMSCs found undesignedly...
ICSI (Intracytoplasmic sperm injection) is one of the most effective treatments for severe male infertility. During implementation ICSI, it necessary to perform three-dimensional positioning tip glass injection micropipette. At present, process mainly controlled by skilled operators. Such manual operation time-consuming and likely cause micropipette damage or even serious oocyte membrane due inaccurate positioning. In this paper, an automatic system was developed The microscopic carried out...
The differentiation of hematopoietic cells is significantly affected by cell metabolic activity. However, despite increasing interest in this field, there has been no comprehensive investigation the functions human during specific phases differentiation. Thus, study was conducted to develop a method for comparing lineage based on cell. activity umbilical cord-derived examined various differentiation, specifically, stem (HSCs), progenitor cells, and differentiated blood cells. This approach...
Haipai culture is unique to Shanghai and holds significant cultural value. Tourism souvenirs,as a key value-added industry in tourism, naturally serve as carriers for conveying local essence play crucial role promoting disseminating culture. To address the current issues of severe homogenization, lack depth, insufficient emotional resonance tourism souvenirs, this paper explores an unconscious design approach these souvenirs based on Extenics narrative theory. Firstly, KANO model utilized...