A5101513801- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Remote Sensing and Land Use
- Immune cells in cancer
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Parvovirus B19 Infection Studies
- Heat shock proteins research
- Adenosine and Purinergic Signaling
- Remote Sensing in Agriculture
- Hematological disorders and diagnostics
- Cancer Research and Treatments
- Herpesvirus Infections and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Institute of Hematology & Blood Diseases Hospital
2013-2024
Hefei University of Technology
2024
Harbin Medical University
2024
Shanghai University of Sport
2024
Shandong Normal University
2023-2024
Academy of Medical Sciences
2019-2023
North Minzu University
2023
Tianjin Medical University General Hospital
2022-2023
National Clinical Research
2020
Interleukin (IL) 12 is a proinflammatory cytokine produced by phagocytic cells, B and other antigen-presenting cells that modulates adaptive immune responses favoring the generation of T helper type 1 cells. IL-12 mediates some its physiological activities acting as potent inducer interferon (IFN) gamma production natural killer IFN-gamma enhances ability to produce cytokines. Thus, IL-12-induced acts in positive feedback loop represents an important amplifying mechanism inflammatory...
Abstract 2D porous carbon materials have demonstrated immense potential in electrochemical energy storage, whereas the challenge of achieving their efficient preparation remains substantial. Herein, with high specific surface area (SSA), well‐developed structures, and controllable layer thickness are successfully prepared by direct co‐pyrolysis agroforestry biomass potassium oxalate. It is found that oxalate acts as reactant its decomposition product carbonate situ template activator. The...
The production of cytokines in monocytes/macrophages is regulated by several different that have activating or inhibitory effects. Interleukin (IL)-10, IL-4, IL-13, and transforming growth factor (TGF)-beta are usually considered to be the most important macrophage-deactivating factors, with effects on cytokine production. Unlike IL-10 TGF-beta, which appear act as downmodulators many phagocytic cell functions, mode action IL-4 IL-13 more complex. Addition peripheral blood mononuclear (PBMC)...
Overexpression of tumor necrosis factor α (TNFα) is a hallmark many inflammatory diseases, including rheumatoid arthritis, bowel disease, and septic shock hepatitis, making it potential therapeutic target for clinical interventions. To explore chemical inhibitors against TNFα activity, we applied computer-aided drug design combined with in vitro cell-based assays identified lead compound, (E)-4-(2-(4-chloro-3-nitrophenyl) (named as C87 thereafter), which directly binds to TNFα, potently...
Summary MLL ‐rearranged ( ‐r) leukaemia is observed in approximately 10% of acute myeloid (AML) and associated with a relatively poor prognosis, highlighting the need for new treatment regimens. fusion proteins produced by rearrangements recruit KDM4C to mediate epigenetic reprogramming, which required maintenance ‐r leukaemia. In this study, we used combinatorial drug screen selectively identify synergistic partners inhibitor SD70. The results showed that combination SD70 MI‐503, potent...
// Nan Wang 1 , Dan Guo YangYang Zhao ChengYa Dong XiaoYan Liu BinXia Yang ShuWei Lin QingGuo Qian Ren YongMin XiaoTong Ma State Key Laboratory of Experimental Hematology, Institute Hematology and Blood Diseases Hospital, Chinese Academy Medical Sciences, Peking Union College, China Correspondence to: Ma, e-mail: maxt@ihcams.ac.cn Keywords: TWIST-1, myeloid leukemia, leukemia stem cell, prognostic factor, c-MPL Received: December 11, 2014 Accepted: May 08,...
Airborne hyperspectral data has high spectral-spatial information. However, how to mine and use this information effectively is still a great challenge. Recently, three-dimensional convolutional neural network (3D-CNN) provides new effective way of classification. its capability mining in complex urban areas, especially cloud shadow areas not been validated. Therefore, 3D-1D-CNN model was proposed for feature extraction with images affected by shadows. Firstly, spectral composition...
Transcription factor Twist-1 plays essential roles in specification and differentiation of mesoderm-derived tissues. Growing evidences now link to the acquisition stem-cell-like properties. However, role hematopoietic stem cell (HSC) remains largely uncharacterized. We report that is more highly expressed murine HSC its expression declines with differentiation. To investigate gene function, retroviral-mediated overexpression or removal experiments are performed. Competitive repopulation...
Mitochondria of hematopoietic stem cells (HSCs) play crucial roles in regulating cell fate and preserving HSC functionality survival. However, the mechanism underlying its regulation remains poorly understood. Here, we identify transcription factor TWIST1 as a novel regulator maintenance through modulating mitochondrial function. We demonstrate that Twist1 deletion results significantly decreased lymphoid-biased (Ly-biased) frequency, markedly reduced dormancy self-renewal capacities, skewed...
Abstract Despite the identification of driver mutations leading to initiation myeloproliferative neoplasms (MPNs), molecular pathogenesis MPNs remains incompletely understood. Here, we demonstrate that growth arrest and DNA damage inducible gamma (GADD45g) is expressed at significantly lower levels in patients with MPNs, JAK2V617F mutation histone deacetylation contribute its reduced expression. Downregulation GADD45g plays a tumor-promoting role human MPN cells. Gadd45g insufficiency murine...
Characterizing genes associated with leukemic cell differentiation may provide help for understanding mechanisms on the leukemia differentiation. The aim of this study is to investigate whether expression melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) could be induced during and mda-7/IL-24 plays a role in We showed that IL-24 delE5, an splice variant, was U937 HL60 cells 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated monocytic Activation mitogen-activated...
Abstract Murine β-defensin 2 (MBD2) is a small antimicrobial peptide of the innate immune system. Recent study showed that MBD2 could not only recruit immature dendritic cells but also activate them by Toll-like receptor 4 and thus may provide critical link between system adaptive response. In this report, we examined antileukemia activity in murine model acute lymphoid leukemia (ALL) L1210. L1210 were engineered to secrete biologically functional MBD2. MBD2-modified (L1210-MBD2)...
Leukemia stem cells (LSCs) are a rare population capable of limitless self-renewal and responsible for the initiation, maintenance, relapse leukemia. Elucidation mechanisms underlying regulation LSC function could provide novel treatment strategies. Here, we show that TWIST1 is extremely highly expressed in LSCs MLL-AF9+ acute myeloid leukemia (AML), its upregulation positively regulated by KDM4C an H3K9me3 demethylation-dependent manner. We further demonstrate essential viability, dormancy,...
A risk assessment method for urban railway investment and financing based on an improved SVM model under big data is proposed. First, the inner product in traditional replaced by a kernel function to obtain more accurate non-linear SVM, classifier with high classification accuracy achieved finding optimal separating hyperplane. Then, index system constructed grounded theory combining intuitionistic fuzzy sets, interval weighted averaging operators distance measure, selection of indexes...
Rapid and accurate classification of urban tree species is crucial for the protection management ecology. However, remains a great challenge because high spatial heterogeneity biodiversity. Addressing this challenge, in study, unmanned aerial vehicle (UAV)-based high-resolution RGB imagery LiDAR data were utilized to extract seven types features, including spectral texture vegetation indexes, HSV height feature, intensity feature. Seven experiments involving different feature combinations...
IL-23 is a novel cytokine composed of an IL-12 p40 and p19 subunit. We analyzed human peripheral blood mononuclear cells (PBMC) hematopoietic cell lines for constitutive expression subunits following exposure to various stimuli, investigated the mechanisms their induction by LPS SAC. p35 mRNAs were expressed in fresh PBMC, all was up-regulated LPS-induced increase CD14-dependent, while CD14 not involved SAC-induced transcription. Both LPS- required p38 MAPK pathway. PHA effected mRNA both...