A5036680742- Phase Equilibria and Thermodynamics
- Thermodynamic properties of mixtures
- Cell death mechanisms and regulation
- Material Dynamics and Properties
- Protein Kinase Regulation and GTPase Signaling
- Cell Adhesion Molecules Research
- Advanced Breast Cancer Therapies
- Chemical and Physical Properties in Aqueous Solutions
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Chemical Thermodynamics and Molecular Structure
- Advanced Thermodynamics and Statistical Mechanics
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Inflammation biomarkers and pathways
- Protein Structure and Dynamics
- Immune Response and Inflammation
- Advanced Polymer Synthesis and Characterization
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Galectins and Cancer Biology
Anhui University of Science and Technology
2024
University of Alabama at Birmingham
2015-2024
Northwest A&F University
2024
Qingdao University
2012-2023
Affiliated Hospital of Qingdao University
2012-2023
Yuhuangding Hospital
2023
AspenTech (United States)
2003-2022
University of Science and Technology Beijing
2018-2021
Breast Center
2018-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
1994-2015
Abstract A generalized electrolyte Non‐Random Two‐Liquid (eNRTL) model proposed by Chen and coworkers is presented as a comprehensive excess Gibbs energy expression to represent the liquid‐phase nonideality for aqueous mixed‐solvent systems over entire concentration range from pure solvents saturated solutions or fused salts. The eNRTL used correlate mean ionic activity coefficients of systems. segment interaction concept provides framework necessary attractive ions with hydrophilic segments...
We present an analytical equation of state based on statistical-mechanical perturbation theory for hard spheres, using the Weeks–Chandler–Andersen decomposition potential and Carnahan–Starling formula pair distribution function at contact, g(d+), but with a different algorithm calculating effective hard-sphere diameter. The second virial coefficient is calculated exactly. Two temperature-dependent quantities in addition to arise, diameter or van der Waals covolume, scaling factor g(d+). Both...
Self-assembling peptides have been previously designed that assemble into macroscopic membranes, nanotapes, and filaments through electrostatic interactions. However, the formation of highly ordered collagen-like fibrils, which display D-periodic features, has yet to be achieved. In this report, we describe for first time a synthetic peptide system self-assembles fibrous structure with well-defined periodicity can visualized by transmission electron microscopy (TEM). Specifically,...
A segment contribution activity coefficient model, derived from the polymer nonrandom two-liquid is proposed for fast, qualitative estimation of solubilities organic nonelectrolytes in common solvents. Conceptually, approach suggests that one account liquid nonideality mixtures complex pharmaceutical molecules and small solvent terms interactions between three pairwise interacting conceptual segments: hydrophobic segment, hydrophilic polar segment. In practice, these segments become...
The electrolyte nonrandom two-liquid (eNRTL) model is reformulated as a symmetric activity coefficient with the reference states chosen to be pure liquids for solvents and fused salts electrolytes. These are consistently used in local interaction term, represented by NRTL expression, long-range an extended Pitzer−Debye−Hückel expression. Retaining electroneutrality like-ion repulsion hypotheses, new yields simpler expressions both molecular ionic species. utility of demonstrated vapor−liquid...
Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up approach for re-engineering the molecular landscape cell surfaces with spatially continuous and molecularly uniform ultrathin films. However, fabricating PEMs on viable cells has proven challenging owing to high cytotoxicity polycations. Here, we report rational engineering new class modular biological functionality tunable physicochemical properties which have been engineered abrogate cytotoxicity....
CYP11A1 and CYP27A1 hydroxylate tachysterol3, a photoproduct of previtamin D3, producing 20S-hydroxytachysterol3 [20S(OH)T3] 25(OH)T3, respectively. Both metabolites were detected in the human epidermis serum. Tachysterol3 was also serum at concentration 7.3 ± 2.5 ng/ml. 20S(OH)T3 25(OH)T3 inhibited proliferation epidermal keratinocytes dermal fibroblasts stimulated expression differentiation anti-oxidative genes similar manner to 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. They acted on vitamin...
We present a new strong principle of corresponding states that reduces the entire pressure–volume–temperature (p–v–T) surface nonpolar fluid to single curve; this curve corresponds an effective pair distribution function at contact as reduced density. This reduction is based on statistical-mechanical theory, which also furnishes algorithms for calculating, from intermolecular potential, three temperature-dependent parameters needed reduction. If potential not known, data second virial...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEquation of state for mixtures hard-sphere chains including copolymersYuhua Song, Stephen M. Lambert, and John PrausnitzCite this: Macromolecules 1994, 27, 2, 441–448Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://doi.org/10.1021/ma00080a018RIGHTS & PERMISSIONSArticle Views316Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full...
// Yanan Zhang 1, 2 , Jie Liu 1 Jing Lin 3 Lei Zhou 4 Yuhua Song 5 Bo Wei 6 Xiaoli Luo Zhida Chen Yingjie Jiaxiu Xiong Xiaojie Xu Lihua Ding Qinong Ye Department of Medical Molecular Biology, Beijing Institute Biotechnology, Collaborative Innovation Center for Cancer Medicine, Beijing, People's Republic China Stem Cell, Center, Dalian University, Liaoning, First Affiliated Hospital, Chinese PLA General Shijitan Capital The Hospital Qing Dao Qingdao, Surgery, Correspondence to: Ye, e-mail:...
Abstract Introduction Triggering receptor expressed on myeloid cells‐2 (TREM2) is an immune microglia that also can become soluble (sTREM2). How TREM2 engages different ligands remains poorly understood. Methods We used comprehensive biolayer interferometry (BLI) analysis to investigate and sTREM2 interactions with apolipoprotein E (apoE) monomeric amyloid beta (Aβ) (mAβ42). Results engagement of apoE was protein mediated little effect lipidation, showing slight affinity differences between...
Abstract Background Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of therapy agents and its affinity loss in multistep synthesis delivery carriers. To address this, we designed an IR792-MCN@ZIF-8-PD-L1 siRNA (IM@ZP) nanoparticle drug system. IM@ZP was prepared by situ physical adsorption, followed characterization. Photothermal conversion ability assessed irradiation near-infrared (NIR) laser,...
Abstract INTRODUCTION The immune receptor triggering expressed on myeloid cells 2 (TREM2) is among the strongest genetic risk factors for Alzheimer's disease (AD) and a therapeutic target. TREM2 multimers have been identified in crystallography implicated efficacy of antibody therapeutics; however, molecular basis multimerization remains poorly understood. METHODS We used dynamics simulations binding energy analysis to determine effects AD‐associated variants validated with experimental...
Abstract A Fabry-Perot resonance-based absorptive structure was investigated. The theoretically calculation results indicate that the design of resonant cavity based on capacitive impedance shows a broadband absorption characteristic. By using random distribution carbon fibers, has been successfully achieved in simple-structured composite. effective bandwidth reaches 8 GHz, with good RCS reduction effect.
This paper describes the development of a comprehensive model for continuous gas-phase synthesis polypropylene using stirred-bed reactors. The considers important issues physical property and thermodynamic selections, polymer properties, catalyst characterization, reactor residence time, in addition to traditional Ziegler−Natta polymerization kinetics. Model involves fundamental chemical engineering principles advanced software tools, Polymers Plus Aspen Dynamics. We characterize by assuming...
Abstract Background c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it reported that overexpression c-Jun in cancer cell line MCF-7 resulted increased AP-1 activity, motility and invasiveness the cells vitro tumor formation nude mice. However, role metastasis human vivo is currently unknown. Methods To further investigate direct involvement tumorigenesis metastasis, present study, effects were studied both Results Ectopic promoted growth a significant...
Thermodynamic modeling of the sulfuric acid−water−sulfur trioxide system is great interest to industry. The recently developed symmetric electrolyte NRTL activity coefficient model applied develop a comprehensive thermodynamic for acid over whole concentration range from pure water sulfur with temperature up 773 K. takes into account partial dissociations and bisulfate ion, hydration hydronium decomposition trioxide, formation disulfuric in concentrated region. Excellent matches between...