A5101854389- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Angiogenesis and VEGF in Cancer
- Ovarian cancer diagnosis and treatment
- Cardiac Ischemia and Reperfusion
- Effects of Radiation Exposure
- Proteoglycans and glycosaminoglycans research
- Endometrial and Cervical Cancer Treatments
- Signaling Pathways in Disease
- Tea Polyphenols and Effects
- Heat shock proteins research
- Reproductive Biology and Fertility
- Receptor Mechanisms and Signaling
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Protein Kinase Regulation and GTPase Signaling
- Nanopore and Nanochannel Transport Studies
- Metallurgy and Material Science
- Heterotopic Ossification and Related Conditions
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
Washington University in St. Louis
2008-2024
Konkuk University
2012-2024
Daegu-Gyeongbuk Medical Innovation Foundation
2020
Korea Institute of Radiological and Medical Sciences
2010-2015
Jeju National University
2011-2015
University of Ulsan
2011
Asan Medical Center
2011
Ulsan College
2011
The University of Texas MD Anderson Cancer Center
2010
Inje University Busan Paik Hospital
2010
Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. is associated with autosomal recessive early onset parkinsonism molecular chaperone. Structural comparisons between DJ-1, Hsp31, an Archaea protease, member of lead the identification chaperone activity proteolytic Hsp31. Moreover, provide insights into how functional diversity realized in proteins that share evolutionarily On basis possible role pathogenesis Parkinson's disease...
Advanced glycation endproducts (AGEs) are believed to be secondary factors in the selective neuronal injury associated with several neurodegenerative disorders. In this study, we investigated protective effects of (−)-epigallocatechin gallate (EGCG), a major monomer green tea polyphenols, against AGEs-induced damage neuron cells. The results showed that EGCG treatment protected glyceraldehyde-derived AGE-induced neurotoxicity, which is an increase intracellular reactive oxygen species, as...
Objective. The purpose of this study was to differentiate between high-grade and non–high-grade ductal carcinoma in situ (DCIS) the breast on sonography. Methods. From October 2003 August 2009, 76 DCIS lesions 73 women who underwent sonography mammography were included study. Lesions confirmed by mastectomy, breast-conserving surgery, or surgical biopsy. Images analyzed 2 radiologists with consensus correlated histologic grades. Results. Of lesions, 44 classified as high--grade 32 DCIS....
Cantú syndrome (CS) is a rare disease characterized by congenital hypertrichosis, distinct facial features, osteochondrodysplasia, and cardiac defects. Recent genetic analysis has revealed that the majority of CS patients carry missense mutation in ABCC9, which codes for sulfonylurea receptor SUR2. SUR2 subunits couple with Kir6.x, inwardly rectifying potassium pore-forming subunits, to form adenosine triphosphate (ATP)-sensitive (KATP) channels, link cell metabolism membrane excitability...
Potassium ion conduction through open potassium channels is essential to control of membrane potentials in all cells. To elucidate the conformation and hence mechanism K + classic inward rectifier Kir2.2, we introduced a negative charge (G178D) at crossing point inner helix bundle, location ligand-dependent gating. This “forced open” mutation generated that were active even complete absence phosphatidylinositol-4,5-bisphosphate (PIP 2 ), an otherwise ligand for Kir channel opening. Crystal...
EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. overexpressed ovarian cancer predictive of poor clinical outcome. However, the biological significance not known focus current study. Here, we examined effects two different methods targeting (a novel monoclonal antibody, EphB4-131 or siRNA) using several models. gene silencing significantly increased tumor cell apoptosis decreased migration (P < 0.001) invasion 0.001)....
To determine the relationship between preoperative hypoalbuminemia and development of complications after gynecological cancer surgery, as well postoperative bowel function hospital stay.The medical records 533 patients with surgery at Konkuk University Hospital 2005 2013 were reviewed. Serum albumin level <3.5 g/dL was defined hypoalbuminemia. All perioperative within 30-days time to resumption normal diet length stay, analyzed. Regression models used assess predictors morbidity.The median...
Background Numerous studies have examined the relationship of bronchial hyperresponsiveness (BHR) to asthma or allergic rhinitis (AR). However, little is known regarding association between BHR and nonallergic (NAR). This study investigated prevalence risk factors in pediatric patients with analyzed difference AR those NAR. Methods A total 227 subjects aged 6–15 years underwent a parental survey laboratory tests, including skin-prick test methacholine challenge test. Outcome variables were...
Phytochemical investigation of the branches Ficus erecta var. sieboldii King resulted in isolation eight constituents: p-hydroxybenzoic acid (1), methyl p-hydroxybenzoate (2), vanillic (3), vanillate (4), syringic (5), β-sitosterol (6), α-amyrin acetate (7), and ethyl linoleate (8). Their chemical structures were identified via spectroscopic means as well by comparing their data with literature values. Studies on tyrosinase inhibition activities conducted for isolated compounds. Among them,...
Abstract Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by M2 helices cytoplasmic end of transmembrane pore. Introduced negative charges HBC (G178D) in Kir2.2 forces opening, allowing pore wetting and free movement permeant ions between cytoplasm inner cavity. Single-channel recordings reveal striking, pH-dependent, subconductance behaviors G178D (or G178E equivalent Kir2.1[G177E]) mutant channels, with well-resolved non-cooperative levels....
Radiation-induced lung injury (RILI) due to nuclear or radiological exposure remains difficult treat because of insufficient clinical data. The goal this study was establish an appropriate and efficient minipig model introduce a thoracic computed tomography (CT)-based method measure the progression RILI. Göttingen minipigs were allocated control irradiation groups. most obvious changes in CT images after peribronchial opacification, interlobular septal thickening, volume loss. Hounsfield...
We reported previously that the human RNF2 (RING finger protein 2) is an E3 ubiquitin ligase interacts with ubiquitin-conjugating enzyme Hip-2/hE2-25K. In present study, we show S6' ATPase, a subunit of proteasomal 19 S regulatory complex. through its N-terminal RING domain, and C-terminal region. Interestingly, RNF2-S6' interaction increases ATP hydrolysis activity protein. Moreover, ATPase highly increased in presence ubiquitinated proteins. The study suggests might have dual function:...
A randomized clinical trial enrolling healthy volunteers was carried out to evaluate the effects of <i>S. muticum</i> supplementation. An experiment conducted investigate whether intake could exert beneficial on human health. Volunteers were asked consume dried encapsulated 4.8 grams daily for 4 weeks. Analysis made several parameters including blood lipid profile, stress hormone level, fatigue status, liver functions, and lymphocyte subpopulation before after consumption capsuls. Fifty-one...
Physiological activity of G protein gated inward rectifier K
제주산 녹차 및 발효 정도를 20%, 50%, 80%로 달리한 3종류의 발효차를 <TEX>$90^{\circ}C$</TEX> 열수에 추출하여 추출물의 항산화능, 지질과산화 억제능 그리고 혈관내피세포(CPAE)를 이용하여 산화스트레스에 대한 세포 보호효과를 조사하였다. 녹차나 다른 발효차에 비해 20% 발효차에서 항산화능을 평가하는 DPPH 소거능이 가장 우수한 것으로 나타났다. 발효차의 80 <TEX>${\mu}g/mL$</TEX> 처리 시 50 <TEX>${\mu}M$</TEX> 농도의 EGCG 처리와 거의 유사한 free radical 소거율을 보였다. 녹차와 발효차 모두 LDL 산화를 억제하여 지질과 산화 억제능을 보였으나 특히 저농도인 40 시에 경우 25~30% 정도 더 LDL의 산화가 억제 되어 <TEX>${\mu}M$</TEX>/mL 시와 동일한 수준의 효과를 CPAE 세포에 추출물을 처리한 실험에서 전혀 처리하지 않은 세포활성이 40~60% 증가하였다. 1 mM...