A5101604541- Neuroinflammation and Neurodegeneration Mechanisms
- Seaweed-derived Bioactive Compounds
- Liver Disease Diagnosis and Treatment
- Food Quality and Safety Studies
- Neurogenesis and neuroplasticity mechanisms
- Cancer Cells and Metastasis
- Nutrition, Health and Food Behavior
- Protein Hydrolysis and Bioactive Peptides
- Organoboron and organosilicon chemistry
- Body Composition Measurement Techniques
- Nerve injury and regeneration
- Cancer, Lipids, and Metabolism
- Nanocomposite Films for Food Packaging
- Meat and Animal Product Quality
- Tuberculosis Research and Epidemiology
- Redox biology and oxidative stress
- Neuroscience and Neuropharmacology Research
- Advanced Photocatalysis Techniques
- Synthesis and Properties of Aromatic Compounds
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Boron and Carbon Nanomaterials Research
- Effects and risks of endocrine disrupting chemicals
- Heat shock proteins research
- Nutritional Studies and Diet
Dankook University
2021-2024
Seoul St. Mary's Hospital
2024
Catholic University of Korea
2024
Korea Disease Control and Prevention Agency
2014-2024
Ewha Womans University
2006-2024
Yonsei University
2023
University of British Columbia
2023
Pohang University of Science and Technology
2003-2021
Ulsan National Institute of Science and Technology
2020-2021
Konkuk University
2020-2021
Curcumin is a natural phenolic component of yellow curry spice, which used in some cultures for the treatment diseases associated with oxidative stress and inflammation. has been reported to be capable preventing death neurons animal models neurodegenerative disorders, but its possible effects on developmental adult neuroplasticity are unknown. In present study, we investigated curcumin mouse multi-potent neural progenitor cells (NPC) hippocampal neurogenesis. exerted biphasic cultured NPC;...
Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. is associated with autosomal recessive early onset parkinsonism molecular chaperone. Structural comparisons between DJ-1, Hsp31, an Archaea protease, member of lead the identification chaperone activity proteolytic Hsp31. Moreover, provide insights into how functional diversity realized in proteins that share evolutionarily On basis possible role pathogenesis Parkinson's disease...
Summary The emergence and dissemination of extended‐spectrum (ES) β‐lactamases induce therapeutic failure a lack eradication clinical isolates even by third‐generation β‐lactam antibiotics like ceftazidime. CMY‐10 is plasmid‐encoded class C β‐lactamase with wide spectrum substrates. Unlike the well‐studied ES from Enterobacter cloacae GC1, Ω‐loop does not affect active site conformation catalytic activity CMY‐10. Instead, three‐amino‐acid deletion in R2‐loop appears to be responsible for...
To identify risk factors and biomarker for early recurrence in patients diagnosed with pancreatic cancer who undergo curative resection. Early after resection of is an obstacle to long-term survival. We retrospectively reviewed 162 underwent was defined as within 12 months surgery. selected S100A2 a investigated its expression using immunohistochemistry. Of the total, 79.6% (n = 129) received adjuvant chemotherapy surgery 117 (72.2%) experienced recurrence, which 73 (45.1%) experience...
Endocrine disruptors (EDs) exert adverse effects on reproductive and immune function or neurological behavior. Bisphenol A (BPA), one of the environmental EDs, is widely used in manufacture plastics epoxy resins. Studies reported that BPA affects organ growth development. However, potential neuronal development have not been fully explored. In this study, potent harmful were investigated murine-derived multipotent neural progenitor cells (NPCs). Pretreatment significantly decreased...
Endocrine-disrupting chemicals (EDC) produce adverse effects on reproductive and immune function or neurological behavior, may also induce cancer. The environmental EDC bisphenol A (BPA) is widely used in the manufacture of plastics epoxy resins. BPA affects organ growth development, but potential neuronal development are not fully understood. Here, concentration-dependently decreased proliferation murine-derived multipotent neural progenitor cells (NPC), high concentrations produced...
Purpose: There are marked differences in facial skeletal characteristics between Asian and Caucasian.However, ethnic age-related changes have not yet been fully established.The aims of this study were to evaluate midfacial skeletons explore structures with aging Caucasian Asian. Materials Methods:The included 108 men (aged 20-79 years) 115 women 20-81 years).Axial CT images a gantry tilt angle 0 analyzed.We measured three-dimensional (3D) coordinates at each point pixel lens cursor picture...
Abstract Polycyclic aromatic hydrocarbons (PAHs) are key components of organic electronics. The electronic properties these carbon‐rich materials can be controlled through doping with heteroatoms such as B and N, however, few convenient syntheses BN‐doped PAHs have been reported. Described herein is the rationally designed, two‐step previously unknown ixene (B 2 N ‐ixene), their characterizations. Compared to ixene, ‐ixene absorbs longer‐wavelength light has a smaller electrochemical energy...
Hsp31, the Escherichia coli hcha gene product, is a molecular chaperone whose activity inhibited by ATP at high temperature. Its crystal structure reveals putative Cys(184), His(185), and Asp(213) catalytic triad similar to that of Pyrococcus horikoshii protease PH1704, suggesting it should display proteolytic activity. A preliminary report has shown Hsp31 an exceedingly weak toward bovine serum albumin peptidase two peptide substrates with small amino acids their N terminus (alanine or...
To screen the fatty acid (FA) composition of 20 marine microalgae species, including seven Diophyceae, six Bacillariophyceae, four Chlorophyceae, two Haptophyceae and one Raphidophyceae species.Microalgal cells cultured at Korea Institute Ocean Science & Technology were harvested during late exponential growth phase FA analyzed.The was species-specific. For example, different species Dinophyceae composed primarily C14:0, C16:0, C18:0, C20:4n-6, C20:5n-3 C22:6n-3, while C16:1, C22:6n-3...
Dietary restriction (DR) increases the life span of many different organisms, and recent findings have demonstrated neuroprotective effects DR in rodent nonhuman primate models neurodegenerative disorders. The mechanism action is unknown, but it may result from a mild cellular stress response involving increased production neurotrophic factors. Because several cytokines are known to be up-regulated brain cells stress, we determined whether affected cytokine expression rat brain. Levels...
In 2006, the Korea Food and Drug Administration reported that combinations of dietary colors such as allura red AC (R40), tartrazine (Y4), sunset yellow FCF (Y5), amaranth (R2), brilliant blue (B1) are widely used in food manufacturing. Although individual tar controlled based on acceptable daily intake (ADI), there is no apparent information available for how these additives affect safety. current study, potencies single combination use R40, Y4, Y5, R2, B1 were examined neural progenitor...
Abstract Mitochondrial movement in neurons is finely regulated to meet the local demand for energy and calcium buffering. Elaborate transport machinery including motor complexes required deliver localize mitochondria appropriate positions. Defects mitochondrial are associated with various neurological disorders without a detailed mechanistic information. In this study, we present evidence that dystrobrevin-binding protein 1 (dysbindin), schizophrenia-associated factor, plays critical role...
The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia mice. Male C57BL/6 mice were anesthetized, and Rose Bengal systemically administered. Permanent focal induced the medial frontal somatosensory cortices by irradiating skull with cold white light. MMP inhibitors, such as doxycycline, minocycline, batimastat, significantly reduced cerebral infarct size,...