A5101853694- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Neuroscience and Neuropharmacology Research
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Microtubule and mitosis dynamics
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cellular Mechanics and Interactions
- Phosphodiesterase function and regulation
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Congenital Anomalies and Fetal Surgery
- Biliary and Gastrointestinal Fistulas
- Traumatic Brain Injury Research
- Advanced Fluorescence Microscopy Techniques
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
Pohang University of Science and Technology
2014-2025
Wonkwang University
2015-2018
Hallym University Kangnam Sacred Heart Hospital
2017-2018
Hallym University
2017
Samsung Medical Center
2013-2016
Sungkyunkwan University
2013-2016
JCR Pharmaceuticals (Japan)
2015
St. Vincent's Hospital
1999
Small nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) usually exhibit minimal or no growth over many years. However, there is a controversy regarding the optimal management of incidentally discovered, small NF-PNETs. This study aimed to gain insights into tumor behavior and potential strategies for clinical management. We retrospectively reviewed total 202 patients with suspected PNET (size 2 cm smaller) at Samsung Medical Center from January 1, 1995 April 30, 2012. Among these...
Cells universally adapt to ischemic conditions by turning on a transcription factor hypoxia-inducible (HIF), in which its role is known differ widely across many different types of cells. Given that microglia have been reported as an essential mediator neuroinflammation brain diseases, we examined the HIF progression acute phase stroke challenging our novel strains myeloid-specific Hif-1α or Hif-2α knockout (KO) mice created Cre-loxP system via middle cerebral artery occlusion (MCAO). We...
Mitochondria-associated ER membrane (MAM) is a structure where these calcium-regulating organelles form close physical contact sites for efficient Ca2+ crosstalk. Despite the central importance of MAM dynamics in diverse biological processes, directly and specifically measuring concentrations inside technically challenging. Here, we develop MAM-Calflux, MAM-specific BRET-based indicator. The successful application bimolecular fluorescence complementation (BiFC) concept highlights...
The neurodevelopmental theory of schizophrenia emphasizes early brain development in its etiology. Genome-wide association studies have linked to genetic variations AS3MT (arsenite methyltransferase) gene, particularly the increased expression d2d3 isoform. To investigate biological basis this with pathophysiology, we established a transgenic mouse model (AS3MT -Tg) ectopically expressing at cortical neural stem cells. -Tg mice exhibited enlarged ventricles and deficits sensorimotor gating...
The objective of this study was to investigate the value cyst fluid carcinoembryonic antigen (CEA) in combination with cytology and viscosity for differential diagnosis pancreatic cysts.We retrospectively reviewed our data patients who underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) analysis. We investigated sensitivity, specificity accuracy CEA, testing.A total 177 EUS-FNA Of these, 48 subjects were histologically clinically confirmed have cysts therefore included...
Background: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is effective for tissue diagnosis of pancreatic mass. To improve diagnostic yield and drawbacks, 22-gauge (G) core biopsy (FNB) needle has been developed. This study aims to compare 22G FNA FNB needles EUS-guided sampling suspected cancer.Methods: a randomized controlled crossover trial. A total 60 patients with unresectable cancer referred were randomly assigned two groups. Both groups had performed in order. The...
Although large-scale genome-wide association studies (GWAS) have identified an between MAD1L1 (Mitotic Arrest Deficient-1 Like 1) and the pathology of schizophrenia, molecular mechanisms underlying this remain unclear. In present study, we aimed to address these by examining role MAD1 (the gene product MAD1L1) in key neurodevelopmental processes mice human organoids. Our findings indicated that is highly expressed during active cortical development deficiency leads impairments neuronal...
In neuronal axons, the ratio of motile-to-stationary mitochondria is tightly regulated by activation, thereby meeting need for local calcium buffering and maintaining ATP supply. However, molecular players detailed regulatory mechanisms behind mitochondrial movement are not completely understood. Here, we found that activation-induced anchoring Disrupted-in-schizophrenia 1 (DISC1), which accomplished functional association with Syntaphilin (SNPH). DISC1 deficiency resulted in reduced axonal...
The endoplasmic reticulum (ER) and mitochondria form a unique subcellular compartment called mitochondria-associated ER membranes (MAMs). Disruption of MAMs impairs Ca2+ homeostasis, triggering pleiotropic effects in the neuronal system. Genome-wide kinase-MAM interactome screening identifies casein kinase 2 alpha 1 (CK2A1) as regulator composition transport MAMs. CK2A1-mediated phosphorylation PACS2 at Ser207/208/213 facilitates MAM localization CK2A1-PACS2-PKD2 complex, regulating...
Enteropathy-associated T-cell lymphoma (EATL) is a rare extranodal arising from the intestine. Two types of EATL have been reported. In contrast to classic type I, II occurs sporadically, unrelated celiac disease, and comprises 10% 20% all cases. A total five cases were diagnosed at our clinic January 2009 September 2012. Four patients with help endoscopy. Among four patients, two involved both small large intestines, whereas in other was limited Common endoscopic findings included...
Neuronal morphogenesis requires multiple regulatory pathways to appropriately determine axonal and dendritic structures, thereby enable the functional neural connectivity. Yet, however, precise mechanisms components that regulate neuronal are still largely unknown. Here, we newly identified sequential phosphorylation of NDEL1 critical for through human kinome screening phospho-proteomics analysis from mouse brain lysate. DYRK2 phosphorylates S336 prime S332 by GSK3β. TARA, an interaction...
Abstract Mitochondrial movement in neurons is finely regulated to meet the local demand for energy and calcium buffering. Elaborate transport machinery including motor complexes required deliver localize mitochondria appropriate positions. Defects mitochondrial are associated with various neurological disorders without a detailed mechanistic information. In this study, we present evidence that dystrobrevin-binding protein 1 (dysbindin), schizophrenia-associated factor, plays critical role...
FMRP is a multifunctional protein encoded by the Fragile X Messenger Ribonucleoprotein 1 gene (FMR1). The inactivation of FMR1 results in fragile syndrome (FXS), serious neurodevelopmental disorder. deficiency causes abnormal neurite outgrowth, which likely to lead learning and memory capabilities. However, mechanism modulating neuronal development remains unknown. We found that enhances translation 4EBP2, neuron-specific form 4EBPs inactivates eIF4E inhibiting interaction between eIF4G....
Abstract Nuclear distribution element-like 1 (Ndel1) plays pivotal roles in diverse biological processes and is implicated the pathogenesis of multiple neurodevelopmental disorders. Ndel1 function by regulating microtubules intermediate filaments; however, its functional link with actin cytoskeleton largely unknown. Here, we show that interacts TRIO-associated repeat on (Tara), an actin-bundling protein, to regulate cell movement. In vitro wound healing Boyden chamber assays revealed Ndel1-...
There is no known useful clinical parameter that can specifically predict a biliary stricture and differentiate it from other related complications after living donor liver transplantations (LDLT). The aims of this study were to determine whether the changes enzymes postoperative apart complications. We reviewed medical records 203 patients who underwent LDLT with duct anastomosis 2008 2010. longitudinal enzyme over time occurrence complication evaluated. A total 124 had up 2 years LDLT, 74...
A diagnosis of acute diverticulitis is based on computed tomography (CT). Colonoscopy commonly performed after the event to exclude other diagnoses. This study aimed determine whether colonoscopy necessary and what additional information gained from a diverticulitis. Acute was diagnosed by clinical criteria characteristic CT findings. We analyzed number patients in whom colorectal cancers were incidental findings polyps diseases. total 177 retrospectively. The mean age 43.3±15.3 years...
Capsaicin (N-vanillyl–8–methyl–1–nonenamide) is a major pungent ingredient in hot peppers and induces apoptosis malignant carcinoma cell lines. However, the adverse effects of capsaicin on neuronal development have not been fully explored. The aim this study was to determine whether affected murine-derived cerebellar multi-potent neural progenitor cells (NPC) or adult hippocampal neurogenesis vivo. dose-dependently suppressed NPC proliferation, higher concentrations were cytotoxic. decreased...
Background/Objectives: No comparative study of 22-gauge biopsy needles (PC22) and 25-gauge (PC25) has been conducted. We prospectively compared the diagnostic accuracy PC22 PC25 in patients with pancreatic peripancreatic solid masses.Methods: conducted a randomized noninferiority clinical from January 2013 to May 2014 at Samsung Medical Center. A cytological histological specimen each pass was analyzed separately by an experienced pathologist. The primary outcome assess using or PC25....