Understanding conformational changes in enzymes upon ligand binding and associated the active site affecting catalysis has been a long-standing problem enzymology. Ketohexokinase (KHK) is an adenosine triphosphate (ATP)- dependent enzyme that catalyzes first reaction fructose metabolism, converting furanose form of D-fructose into 1-phosphate. KHK homodimer exists as two isoforms, KHK-A KHK-C. The C isozyme mainly expressed liver kidney functions fructolytic allow carbon to enter glycolytic...

OBJECTIVES Robotic thymectomy via the subxiphoid approach (RTX) is a recently introduced surgical approach. This study aimed to report on technique and early outcomes of RTX in our institute. METHODS was performed using 3-arm da Vinci robotic system. The camera inserted into port, 2 arms were bilateral intercostal ports. A complete dissection both cervical poles up thyroid gland conducted, phrenic nerves identified all cases. Radical combined resection adjacent organs, including lung,...

Killian-Jamieson (K-J) diverticula have been incidentally detected on neck ultrasonography and could be misdiagnosed as thyroid nodules. The purpose of this study was to define the clinical ultrasonographic characteristics K-J diverticula.We analyzed 13 patients with mimicking nodules including 4 our 11 previously reported cases between 1984 August 2009.Seven (54%) were women, all asymptomatic. average lesion's diameter 1.5 cm (range, 0.5-4.0). Most lesions (92%) located in left lobe....

Electromagnetic navigation bronchoscopy (ENB)-guided dye marking is a useful localization method for small pulmonary nodules. This study evaluated the efficacy and safety of intraoperative full virtual ENB-guided marking.Patients who underwent without adjunct imaging (fluoroscopy or cone-beam computed tomography) nodules were investigated retrospectively. Efficacy was on basis success rates (visible mark) nodule localization, rate ENB-related complications.ENB-guided performed 164 in 134...

Background/Aims The aim of this study was to identify the parameters that could noninvasively predict presence esophageal/gastric varices and portal hypertensive gastropathy (PHG) in patients with chronic liver disease (CLD), determine accuracy those parameters. Methods We retrospectively analyzed 232 CLD who underwent both upper endoscopy CT within an interval 3 months. multidimensional index (M-Index) for spleen volume obtained from multiplication splenic length, width, thickness, as...

The relationship between the size of bullae and pneumothorax recurrence is controversial. aim this study was to retrospectively evaluate role blebs or in predicting ipsilateral young patients experiencing their first episode primary spontaneous (PSP) who underwent conservative treatment.A total 299 cases first-episode PSP were analyzed. status reviewed on high-resolution computed tomography (HRCT). dystrophic severity score (DSS; range, 0 6 points) calculated based HRCT.The 5-year rate...

Objective: To evaluate the correlation between bone tunnel diameter after anterior cruciate ligament (ACL) reconstruction measured by computed tomography (CT) using multiplanar (MPR) and stability or clinical scores.Materials Methods: Forty-seven patients (41 men 6 women, mean age: 34 years) who had undergone ACL with double bundle technique auto-hamstring graft subsequently received CT scans immediately surgery (T1: range, 1-4 days, mean, 2.5 days) at a later time (T2: 297-644 410.4 were...

The current understanding of pulmonary invasive mucinous adenocarcinoma is largely based on studies advanced stage patients and data about early-stage are sparse. We evaluated the radiological clinical features screening-detected (SD-IMA).Data from 91 who underwent surgical treatment for SD-IMA (≤3 cm) 2013 to 2019 were reviewed retrospectively. Data characteristics, clinicopathological findings, recurrence survival obtained. Disease-free rate was analysed.Radiologically, SD-IMAs presented...

Purpose: Mycobacterium tuberculosis is endemic in Korea.Because tuberculous peritonitis characterized by ascites, abdominal pain, mass and elevation of serum CA-125, it can be confused with ovarian malignancies.The aim this study was to evaluate the significance CA-125 level differential diagnosis malignancy a tuberculosis-endemic area.Materials Methods: The medical records patients diagnosed (n=48) or epithelial (n=370) at Samsung Medical Center from January 2000 October 2009 were...

Primary frontal sinus lymphoma is a very uncommon disease.In all the previously reported cases, presenting symptoms have been due to tumor mass effect.We present an unusual case report of immunocompetent patient who presented with facial palsy, and then progressively developed other cranial nerve palsies over several months.He was later diagnosed diffuse large B cell originating from sinus.The underwent chemotherapy, but eventually had receive autologous peripheral blood stem...

See the commentary-article "Noninvasive diagnostic criteria for hepatocellular carcinoma" on page 174.

Sarcoidosis is an inflammatory disease of unknown cause which characterized by the presence noncaseating granulomas. The association sarcoidosis with malignancy has been issue and remains controversial. We herein report endobronchial carcinoid tumor in a patient diagnosed nasal mucosal biopsy, excisional biopsy cervical lymph nodes mediastinal node dissection.

So Young Bae, Hye-seon Kim, Hyo-Jun Jang, Won-Sang Chung, Hyuck Hak Jun Ho Lee, and Seong Sik Bang. Korean J Thorac Cardiovasc Surg 2018;51:410-4. https://doi.org/10.5090/kjtcs.2018.51.6.410

We compared the safety and effectiveness of robotic anatomical resection video-assisted thoracoscopic surgery (VATS).A retrospective analysis was conducted records 4,283 patients, in whom an attempt made to perform minimally invasive for lung cancer at Seoul National University Hospital from January 2011 July 2020. Of these 138 underwent 4,145 VATS. Perioperative outcomes were after propensity score matching including age, sex, height, weight, pulmonary function, smoking status, performance...

This study investigates the effects of heat input on microstructure and fracture toughness SAW (Submerged Arc Welding) joints with K-groove X-groove weld preparations using S460NL steel. Microstructural analysis focused acicular ferrite, grain boundary MA (Martensite–Austenite) constituents to assess their influence CTOD (Crack Tip Opening Displacement). The results indicate that achieved a higher value 0.82 mm compared 0.13 for X-groove, attributed differences in microstructural composition...

Capillary hemangioma of the trachea is an extremely rare benign tumor in adults. We present case a 28-year-old woman with hemoptysis owing to proximal trachea. The was removed by rigid bronchoscopy. resulting specimens showed capillary without any signs malignant transformation. This presentation first Korea. Although tracheal disease, we should consider it as possible cause young adult.

Methods: We retrospectively reviewed 120 patients who were classified as having triple-negative breast cancer (by immunohistochemical technique).The all of them came from 4 public hospitals and 3 private in Bangkok between January 2000 October 2010.The patient characteristics, tumor treatment outcomes had been collected, then mapping with demographic data, staging, treatent outcome.The simple Cox proportional hazard model was used to identify independent prognostic factors our study.Results:...

Purpose: To analyze chest radiographic findings in children infected with laboratoryconfirmed novel swine-origin influenza A (H1N1) virus. Materials and Methods: Three hundred seventy-two out of 2,014 laboratory confirmed H1N1 infection who also underwent a radiograph from September to November 2009 were enrolled this study. Patients divided into in-patients, out-patients, patients co-infections further subdivided underlying disease without as well age (<2 years old, 2-5 years, 5-10 10-18...