A5055913466- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Acute Myeloid Leukemia Research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Plant Molecular Biology Research
- Chromatin Remodeling and Cancer
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Protein Degradation and Inhibitors
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- Biomedical Ethics and Regulation
- Genetic Associations and Epidemiology
- Chromosomal and Genetic Variations
- Ovarian cancer diagnosis and treatment
Pohang University of Science and Technology
2021-2025
Stanford University
2020-2022
Johns Hopkins Medicine
2010-2015
Johns Hopkins University
2010-2015
Seoul National University Hospital
2011
Seoul National University Bundang Hospital
2011
Abstract Acute myeloid leukaemia (AML) is characterized by subpopulations of stem cells (LSCs) that are defined their ability to engraft in immunodeficient mice. Here we show an LSC DNA methylation signature, derived from xenografts and integration with gene expression comprised 71 genes identifies a key role for the HOXA cluster. Most epigenetically regulated independently underlying mutations, although several downstream targets epigenetic modifier mutated AML. The signature associated...
The neurodevelopmental theory of schizophrenia emphasizes early brain development in its etiology. Genome-wide association studies have linked to genetic variations AS3MT (arsenite methyltransferase) gene, particularly the increased expression d2d3 isoform. To investigate biological basis this with pathophysiology, we established a transgenic mouse model (AS3MT -Tg) ectopically expressing at cortical neural stem cells. -Tg mice exhibited enlarged ventricles and deficits sensorimotor gating...
Gene expression is controlled by transcription factors (TFs) that bind cognate DNA motif sequences in cis-regulatory elements (CREs). The combinations of motifs acting within homeostasis and disease, however, are unclear. expression, chromatin accessibility, TF footprinting, H3K27ac-dependent looping data were generated a random-forest-based model was applied to identify 7,531 cell-type-specific modules (CRMs) across 15 diploid human cell types. A co-enrichment framework CRMs nominated 838...
Other SectionsABSTRACTINTRODUCTIONHIGHER-ORDER GENOME STRUCTURE: PRINCIPLES AND PLAYERSTECHNOLOGIES TO STUDY CHROMOSOME ARCHITECTURECONCLUSIONS FUTURE DIRECTIONSACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGURESTABLEREFERENCES
Transcription factors (TFs) bind DNA sequence motif vocabularies in cis-regulatory elements (CREs) to modulate chromatin state and gene expression during cell transitions. A quantitative understanding of how lexicons influence dynamic regulatory activity has been elusive due the combinatorial nature code. To address this, we undertook multi-omic data profiling dynamics across epidermal differentiation identify 40,103 CREs associated with 3,609 dynamically expressed genes, then applied an...
Abstract Background: Although DNA methylation profiles in breast cancer have been connected to molecular subtype, there no studies of the association with stem cell phenotype. This study was designed evaluate promoter CpG islands 15 genes regard subtype and investigate whether patterns island each are associated phenotype represented by CD44+/CD24- or ALDH1 expression. Methods: We performed MethyLight analysis for status loci involved progression (APC, DLEC1, GRIN2B, GSTP1, HOXA1, HOXA10,...