A5101887366- Ion channel regulation and function
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Electrochemical sensors and biosensors
- Analytical Chemistry and Chromatography
- Biofuel production and bioconversion
- Electrochemical Analysis and Applications
- Enzyme Structure and Function
- Lipid Membrane Structure and Behavior
- Nicotinic Acetylcholine Receptors Study
- Conducting polymers and applications
- Cardiac Ischemia and Reperfusion
- Analytical Chemistry and Sensors
- Bone health and treatments
- Advanced Chemical Sensor Technologies
- Smart Grid Energy Management
- Angiogenesis and VEGF in Cancer
- Gas Sensing Nanomaterials and Sensors
- Ion Transport and Channel Regulation
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Advanced biosensing and bioanalysis techniques
- Perovskite Materials and Applications
Xiamen University
2016-2025
Jiangsu Vocational College of Medicine
2016-2024
University of Missouri–Kansas City
2019-2024
Fuyang Normal University
2024
Taiyuan University of Technology
2023-2024
Wuhan University of Science and Technology
2020-2023
University of California, San Diego
2021-2023
Nanjing Tech University
2020-2022
Universität Hamburg
2021
Hamburg University of Technology
2021
In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is reaction-diffusion type, takes into account the complex interactions between and surrounding stromal cells by including densities endothelial extra-cellular matrix. When no treatment applied reproduces typical dynamics early initially avascular reaches diffusion limited size order millimeters initiates angiogenesis through release vascular growth factor (VEGF) secreted hypoxic core tumor. This...
Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir require interaction of phosphatidyl-4,5-bisphosphate (PIP2) at a crystallographically identified binding site, but an additional nonspecific secondary anionic phospholipid (PL(−)) is required to generate high PIP2 sensitivity Kir2 channel gating. The PL(−)-binding site and mechanism are yet be elucidated. Here we report docking simulations that identify putative adjacent the PIP2-binding generated by two lysine...
Abstract This study reports the application of peptide linker in construction bi‐functional formate dehydrogenase (FDH) and leucine (LeuDH) enzymatic complex for efficient cofactor regeneration L‐tert (L‐tle) biotransformation. Seven FDH‐LeuDH fusion enzymes with different were successfully developed displayed both parental enzyme activities. The incorporation order FDH LeuDH was investigated by predicting three‐dimensional structures LeuDH‐FDH models using I‐TASSER server. characterization...
Abstract Graphene oxide‐based nanomaterials are promising for enzyme immobilization due to the possibilities of functionalizing surface. Polyethylenimine‐grafted graphene oxide was constructed as a novel scaffold formate dehydrogenase. Compared with free dehydrogenase and adsorbed dehydrogenase, thermostability, storage stability, reusability polyethylenimine‐grafted oxide‐formate were enhanced. Typically, remained 47.4% activity after eight times’ repeat reaction. The immobilized capacity...
Voltage-gated proton (Hv) channels are standalone voltage sensors without separate ion conductive pores. They gated by both and transmembrane gradient (i.e., ∆pH), serving as acid extruders in most cells. Like the canonical sensors, Hv a bundle of four helices (named S1 -S4), with S4 segment carrying three positively charged Arg residues. Extensive structural electrophysiological studies on voltage-gated channels, general, agree an outwards movement upon activating voltage, but real-time...
The sulfonylurea receptor SUR1 associates with Kir6.2 or Kir6.1 to form KATP channels, which link metabolism excitability in multiple cell types. strong physical coupling of Kir6 subunits appears exclusive, but recent studies argue that also modulates TRPM4, a member the transient potential family non-selective cation channels. It has been reported that, following stroke, brain, spinal cord injury, is increased neurovascular cells at site injury. This accompanied by up-regulation conductance...
Although human sperm is morphologically mature in the epididymis, it cannot fertilize eggs before capacitation. Cholesterol efflux from plasma membrane a key molecular event essential for cytoplasmic alkalinization and hyperactivation, but underlying mechanism remains unclear. The voltage-gated proton (hHv1) channel functions as an acid extruder to regulate intracellular pHs of many cell types, including sperm. Aside voltage pH, Hv channels are also regulated by distinct ligands, such Zn 2+...