About
Contact & Profiles
A5017789481
Research Areas
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Lipid Membrane Structure and Behavior
University of Missouri–Kansas City
2022
Although human sperm is morphologically mature in the epididymis, it cannot fertilize eggs before capacitation. Cholesterol efflux from plasma membrane a key molecular event essential for cytoplasmic alkalinization and hyperactivation, but underlying mechanism remains unclear. The voltage-gated proton (hHv1) channel functions as an acid extruder to regulate intracellular pHs of many cell types, including sperm. Aside voltage pH, Hv channels are also regulated by distinct ligands, such Zn 2+...
10.1073/pnas.2205420119
article
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cc-by-nc-nd
Proceedings of the National Academy of Sciences
2022-08-29
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