A5072344693- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Hedgehog Signaling Pathway Studies
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Bone and Joint Diseases
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- CAR-T cell therapy research
- Pluripotent Stem Cells Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- CRISPR and Genetic Engineering
- Membrane Separation and Gas Transport
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Medical Imaging Techniques and Applications
- Mechanisms of cancer metastasis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Wound Healing and Treatments
- Advanced Glycation End Products research
- Hydrogen Storage and Materials
- vaccines and immunoinformatics approaches
Institute of Hematology & Blood Diseases Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
China Pharmaceutical University
2024
Fudan University
2020-2022
China-Japan Friendship Hospital
2021-2022
Peking University
2021
Nanfang Hospital
2016-2020
Southern Medical University
2016-2020
Key Laboratory of Guangdong Province
2017-2020
The Ohio State University
2016
Abstract The transcriptional factor Forkhead box k1 (FOXK1) is a member of the FOX family. abnormal expression FOXK1 may have an important role in tumour development. Our previous studies showed that four-and-a-half LIM protein 2 (FHL2) critical inducer epithelial-to-mesenchymal transition (EMT) and invasion. However, molecular mechanism by which synergizes with FHL2 proliferation, EMT metastasis not well defined. We evaluated messenger RNA (mRNA) levels quantitative RT–PCR, western blot,...
Diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) are subtypes of non-Hogkin (NHL) that generally distinct form one cases, but the transformation these diseases into other is possible. Some patients with CLL, for instance, have potential to develop Richter such they diagnosed a rare, invasive DLBCL subtype. In this study, bioinformatics analyses two NHL were conducted, identifying key patterns gene expression then experimentally validating results. Disease-related...
Abstract Background Stem cells, including induced pluripotent stem cells (iPSCs), have tremendous potential in health care, though with several significant limitations. Each of the limitations, immunogenicity, may block most therapeutic potentials. Beta2 microglobulin (B2M) and MHC II transactivator (CIITA) are critical for I II, respectively. MHCs responsible immunogenic recognition. Methods B2M CIITA were knocked out from human iPSCs, either separately or simultaneously. The effects single...
Tumor suppressor candidate 3 (TUSC3) is a coding gene responsible for N-glycosylation of many critical proteins. TUSC3 plays an oncogenic role in colorectal cancer (CRC), however, the drug resistance CRC still unclear. The aim this study to investigate biological function and molecular mechanism resistance. expression positively correlated tumor stage 90 paired clinical samples, negatively associated with overall survival disease-free patients. In vitro, promotes formation stemness induces...
Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming reduce toxicity and improve targeted release properties colchicine binding site inhibitors (CBSIs) based on previous work, a series biologically inert prodrugs were further designed synthesized through bioorthogonal prodrug strategy. The therapeutic effects could be "turned-on" once combined with palladium resins. Particularly, 2b was 68.3-fold less cytotoxic...
// Bing Li 1,2,* , Jinqin Liu 2,* Shiqiang Qu 1,* Robert Peter Gale 3 Zhen Song 4 Ruixian Xing 1 Junxia 5 Yansong Ren Zefeng Xu 1,2 Tiejun Qin Yue Zhang Liwei Fang Hongli Lijuan Pan Naibo Hu Wenyu Cai 6 Peihong Gang Huang 7 and Zhijian Xiao MDS MPN Centre, Institute of Hematology Blood Diseases Hospital, Chinese Academy Medical Sciences & Peking Union College, Tianjin, China 2 State Key Laboratory Experimental Hematology, Department Medicine, Haematology Section, Division Imperial...
T-cell acute lymphoblastic leukemia (T - ALL)/T-cell lymphoma (T-LBL) is an uncommon but highly aggressive hematological malignancy. It has high recurrence and mortality rates challenging to treat. This study conducted bioinformatics analyses, compared genetic expression profiles of healthy controls with patients having T-ALL/T-LBL, verified the results through serological indicators. Data were acquired from GSE48558 dataset Gene Expression Omnibus (GEO). T-ALL normal T cells-related...
Abstract Background Induced pluripotent stem cells (iPSCs) have the potential to promote wound healing; however, their adhesion extracellular matrix (ECM) might decrease iPSC migration, thereby limiting therapeutic potential. Integrin β1 (Itgb1) is major integrin subunit that mediates iPSC-ECM adhesion, suggesting knocking out Itgb1 be an effective method for enhancing efficacy of iPSCs. Methods We knocked in mouse iPSCs and evaluated its effects on topically applied iPSCs, as well...
Pulmonary endothelial cell injury is a hallmark of acute lung injury. High-mobility group box 1 (HMGB1) can modulate the inflammatory response via activation and release molecules. Thus, we tested whether induced pluripotent stem cells (iPSCs) alleviate ischemia/reperfusion (I/R) injury, and, if so, HMGB1 mediates effect in male C57BL/6 mouse model. Intravenously injected iPSCs into mice 2 h after I/R showed significant attenuation (assessed by mechanics, edema, histology) 24 reperfusion...
Background Only a few studies exist that have assessed the efficacy of autologous osteochondral transplantation (AOT) treatment osteonecrosis (ON) knee. The purpose this study was to clarify clinical and radiographic results AOT performed on young patients with postcollapse ON Methods This retrospective included 14 (6 men, 8 women, mean age 34.71 ± 5.41 years) stage III knee undergoing surgery. Mean follow-up time 87 10.23 months. postoperative radiological evaluations were based Hospital...
Myelodysplastic syndrome (MDS) is difficult to diagnose and classify because it has the potential evolve into acute myeloid leukemia (AML). Raman spectroscopy orthogonal partial least squares discrimination analysis (OPLS-DA) are used systematically analyze peripheral blood serum samples from 33 patients with MDS, 25 AML, 29 control volunteers gain insight heterogeneity of metabolism in MDS AML. AML show unique spectral data compared considerably greater peak intensities collagen (859 1345...
Background: Novel coronavirus disease (COVID-19) is an ongoing pandemic with no cure. It imperative to employ low-cost interventions contain its spread. In the present study, role of ambient temperature (AT) in predicting and controlling risk COVID-19 spread were evaluated. Methods: Data on monthly new deaths or cases per million population (MDPM MCPM) cumulated days more than previous day (DI) from March 1 May 30, 2020 collected. data all 118 countries over five analyzed. Findings: Monthly...
Natural products always are a major source for cancer drug research and development. Several phyllanthusmin analogues isolated from Phyllanthus poilanei, collected in Vietnam, exhibited significant cytotoxic activity HT-29 colon cells, particularly D (0.17µM). Twelve new derivatives were synthesized to optimize anticancer drug-like properties. After testing the against panel of derivative Phy-14 high potential DU145 prostate cell (ED50 0.27µM). also dose-dependent Reactive Oxygen Species...
Abstract Objective To observe the comparability of serum‐free light chain (sFLC) detected by Beckman, Siemens, and Binding Site. Methods In this study, 110 patients who were diagnosed with multiple myeloma in State Key Laboratory Experimental Hematology from November 2019 to August 2020. According instructions equipment reagent manufacturers, three detection systems (Binding Site, Siemens) used detect selected analysis samples. Meanwhile, sFLC test results instruments compared. EP9‐A3 guide,...
Objective: Hepatic amyloidosis is a metabolic disease with low incidence rate. However, because of its insidious onset, the rate misdiagnosis high, and it usually progresses to late stage when diagnosed. This article analyzes clinical features hepatic by combining pathology in order improve diagnosis Methods: Clinical pathological data 11 cases diagnosed at China-Japan Friendship Hospital from 2003 2017 were summarized analyzed retrospectively. Results: The manifestations mainly included...
Objective To investigate the comparability of Freelite, Binding Site, Beckman and N Latex FLC, Siemens in detection serum free light chain (sFLC) . Methods Fifty newly diagnosed multiple myeloma (MM) patients Tianjin Institute Blood Research from November 2019 to February 2020 were enrolled. The two systems (Freelite, Siemens) used detect sFLC samples. Outlier was performed by ESD method, methodological comparison deviation assessment Passing-Bablok regression Bland-Altman regression....