A5100652634- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Acute Kidney Injury Research
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Pneumonia and Respiratory Infections
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Abdominal Trauma and Injuries
- Hemodynamic Monitoring and Therapy
- Hematopoietic Stem Cell Transplantation
- Hepatitis B Virus Studies
Zhengzhou Central Hospital
2025
Wuhan University
2012-2024
Hua Medicine (China)
2024
Harbin Medical University
2013-2024
Third Affiliated Hospital of Harbin Medical University
2024
Peking University
2024
Zhongnan Hospital of Wuhan University
2012-2024
Lanzhou University
2024
First Hospital of Lanzhou University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Growing evidence indicates that long non-coding RNAs (lncRNAs) may be potential biomarkers and therapeutic targets for many disease conditions, including cancer.In this study, we constructed a risk score system of three lncRNAs (LOC101927051, LINC00667 NSUN5P2) predicting the prognosis small hepatocellular carcinoma (sHCC) (maximum tumor diameter ≤5 cm).The prognostic value sHCC model was confirmed in TCGA HCC samples (TNM stage I II).Stratified survival analysis revealed suitable patient...
Abstract Background The lack of transparency is a prevalent issue among the current machine-learning (ML) algorithms utilized for predicting mortality risk. Herein, we aimed to improve by utilizing latest ML explicable technology, SHapley Additive exPlanation (SHAP), develop predictive model critically ill patients. Methods We extracted data from Medical Information Mart Intensive Care IV database, encompassing all intensive care unit admissions. employed nine different methods models. most...
Liver cancer is among the most prevalent cancers worldwide and second leading cause of cancer-related death. Epidemiological evidence suggests a potential correlation between dietary habits incidence liver cancer. However, establishing definitive causal relationship remains uncertain. Mendelian randomization (MR) frequently employed to investigate link exposure results. This research focuses primarily on exploring confirming whether there connection choices risk Exposure data, encompassing...
Abstract Background and Aim It was commonly accepted that chemotherapeutic cytotoxicity the main cause for hepatic failure in hepatocellular carcinoma patients after repeated transarterial chemoembolization ( TACE ). However, effect of embolization‐induced hypoxia on liver cirrhosis has rarely been concerned. Methods Serum levels alanine aminotransferase, aspartate albumin were used to detect injury. Hepatic artery ligation performed carbon tetrachloride‐induced rat fibrosis model mimic . S...
Abstract Background Artificial intelligence (AI) tools are more effective if accepted by clinicians. We developed an AI-based clinical decision support system (CDSS) to facilitate vancomycin dosing. This qualitative study assesses clinicians' perceptions regarding CDSS implementation. Methods Thirteen semi-structured interviews were conducted with critical care pharmacists, at Mayo Clinic (Rochester, MN), from March through April 2020. Eight cases discussed each pharmacist ( N = 104)....
The incidence and mortality of gynecological tumors are progressively increasing due to factors such as obesity, viral infection, unhealthy habits, well social economic pressures.Consequently, it has emerged a significant threat women's health.Numerous studies have revealed the remarkable metabolic activity tumor cells in glycolysis its ability influence malignant biological behavior through specific mechanisms.Therefore, is crucial for patients gynecologists comprehend role glycolytic...
To develop a modified Fistula Risk Score (FRS) for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatoduodenectomy (PD) based on both FRS and contrast-enhanced computed tomography (CE-CT).In this multicenter retrospective analysis, we focused 990 consecutive patients with performed at four institutions between 2009 2019. The enhanced CT-FRS model initially targeted 26 pre- intraoperative factors, including CT descriptors, elements clinical using...
Accumulating evidence indicates that systemic inflammation response is associated with the prognosis of various cancers. The aim this study was to investigate neutrophil-lymphocyte ratio (NLR), which one markers, in hepatocellular carcinoma (HCC) after treatment transcatheter arterial chemoembolization (TACE).The clinical data 178 HCC patients who received TACE were retrospectively analyzed. optimal NLR cutoff determined according receiver operating characteristic (ROC) analysis. All divided...
Abstract To assess the relationship between acute kidney injury (AKI) with outcomes among patients requiring extracorporeal membrane oxygenation (ECMO). This is a single-center, retrospective cohort study of adult admitted to intensive care units (ICU) at tertiary referral hospital ECMO from July 1, 2015, August 30, 2019. We assessed temporal AKI and renal replacement therapy type (VV vs. VA). The primary outcome was in-hospital mortality rates. used Kruskal–Wallis or chi-square tests for...
Abstract Introduction Dilated cardiomyopathy (DCM) is characterized by the enlargement of left ventricle or biventricular, accompanied myocardial systolic dysfunction. Chlamydia psittacosis (CP) a zoonotic pathogen, which can cause severe pneumonia, respiratory failure, and acute organ The deterioration DCM caused CP infection extremely rare, few cases successful management were reported. Case presentation We reported 67-year-old male patient with chronic heart failure. Who was admitted to...
Abstract Aims Both hypercapnia and hypocapnia are common in patients with acute heart failure (AHF), but the association between partial pressure of arterial carbon dioxide (PaCO 2 ) AHF prognosis remains unclear. The objective this study was to investigate connection PaCO within 24 h after admission intensive care unit (ICU) mortality during hospitalization at 1 year patients. Methods results were enrolled from Medical Information Mart for Intensive Care IV database. divided into three...
Aerosolized amikacin (AA) is a current option for the management of ventilator-associated pneumonia (VAP) caused by multidrug-resistant Gram-negative bacteria (MDR-GNB), as it reported that AA could increase alveolar level drug without increasing systemic toxicity. This study aimed to evaluate efficacy and safety an adjunctive therapy VAP MDR-GNB.In this single-center, double-blind conducted in 36-bed general Intensive Care Unit (ICU) tertiary hospital from June 2014 2016, 52 ICU patients...
Dexmedetomidine (DEX) as a nerve block adjuvant can significantly prolong analgesia. However, whether perineural or systemic administration of DEX is more beneficial in patients undergoing total knee arthroplasty (TKA) has not been thoroughly investigated. To this end, we evaluated the effects and on postoperative analgesia TKA surgery.We randomly assigned under general anesthesia combined with femoral sciatic to one three groups: (1) ropivacaine plus dexmedetomidine (DP): 0.25% 40 mL 0.5...
Background Large‐scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE). Purpose To determine MRE‐based values examine related influential factors. Study Type Prospective. Subjects In all, 361 volunteers (men, 199; women, 162) with a median age 54.0 years body mass index (BMI) 22.86 kg/m 2 were prospectively recruited. Those no histories smoking, alcohol abuse, diabetes mellitus (DM) grouped as healthy...
Laparoscopic procedures for pancreatic surgery have been significantly improved recently; however, only a limited number of successful laparoscopic or laparoscopy-assisted pancreaticoduodenectomy (PD) reported. The limitations could be attributed to the complexity reconstruction under observation and high incidence complications. Postoperative fistula (POPF) has regarded traditionally as most frequent major complication is potentially serious life-threatening event. It remains single...
Emerging evidence suggests a tentative association between cathepsins and uterine leiomyoma (UL). Previous investigations have predominantly focused on the role of in metastasis colonization gynecological malignancies. Still, observational studies may lead to confounding biases. We employed bidirectional Mendelian randomization (MR) analysis elucidate causative links various UL. Instrumental variables (IVs) UL within European cohort were from extant genome-wide study datasets. Sensitivity...
Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer: Results from 24 hospitals China
Abstract Acute respiratory distress syndrome (ARDS) is not a genetic disease, but gene polymorphism influences the susceptibility, severity and prognosis of ARDS. It has been reported that genes, such as angiotensin-converting enzyme extracellular superoxide dismutase 3 related to Research on ARDS currently in preclinical stage, it develops fast, In future, ARDS-related may play an important role identifying susceptibility risk, assessing revealing new etiology pathophysiological mechanisms,...
Hepatocellular carcinoma (HCC) remains a severe health issue worldwide, especially in Asia. To date, molecular classifications proposed for the overall survival (OS) or recurrence-free (RFS) prediction of Asian HCC patients after hepatectomy are quite few and limited clinical practice. Here, we established subtyping system to facilitate prognosis evaluation. Firstly, differentially expressed genes (DEGs) (FDR [false discovery rate] <0.05) between different types liver cancer non-tumor tissue...