A5101990640- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Pain Management
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Flavonoids in Medical Research
- Natural product bioactivities and synthesis
- Anesthesia and Sedative Agents
- Advanced Glycation End Products research
- Cardiac, Anesthesia and Surgical Outcomes
- Phytochemistry and Biological Activities
- S100 Proteins and Annexins
- Traditional Chinese Medicine Analysis
- Electrical and Bioimpedance Tomography
- Medical Research and Treatments
- Pregnancy and preeclampsia studies
- Bioactive natural compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Total Knee Arthroplasty Outcomes
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- Nerve Injury and Rehabilitation
- Andrographolide Research and Applications
- Hydrogen's biological and therapeutic effects
- Medicinal Plants and Neuroprotection
XinHua Hospital
2017-2025
Shanghai Jiao Tong University
2015-2025
Anhui Medical University
2019-2023
First Affiliated Hospital of Anhui Medical University
2019-2023
Peking University
2020
Peking University Third Hospital
2020
Nanjing Maternity and Child Health Care Hospital
2019
Jinzhou Medical University
2011-2018
Provo College
2016
Brigham Young University
2014-2016
Although recent progress provides mechanistic insights into diabetic nephropathy (DN), effective treatments remain scarce. DN, characterized by proteinuria and a progressive decline in renal function, primarily arises from podocyte injury, which impairs the glomerular filtration barrier. Wogonoside, bioactive compound traditional Chinese herb Scutellaria baicalensis, has not been explored for its role DN. This study aimed to investigate therapeutic effects of wogonoside on injury DN...
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly population. In treatment of AD, some obstacles, including drug penetration difficulty through blood-brain barrier (BBB), inadequate clearance Aβ peptide, and massive release inflammatory factors, must be urgently overcome. To solve these problems, we developed special novel nanoparticles (NPs) made chitosan (CS) bovine serum albumin (BSA) to enhance drugs BBB. Curcumin as a potent anti-inflammatory agent was...
Cerebral ischemia-reperfusion (CI/R) injury remains a major medical problem due to the lack of effective therapies. Previous studies have shown that increasing activity transcription factor nuclear erythroid 2-related 2 (Nrf2) and gene targets in cell culture stroke animal models is highly neuroprotective. Oxymatrine quinolizidine alkaloid extracted from root Sophora flavescens AIT, has been proved be protective after ischemia recent studies. The present study was designed investigate...
Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play roles development neuroinflammation, and may accelerate progression AD. Andrographolide (ANDRO), potent naturally extracted substance, has been demonstrated to exert suppressive effects on LPS-induced inflammation by modulating macrophage microglia overactivation. Whereas AD, β-amyloid (Aβ) peptides have considered as...
Overdose deaths and non-fatal overdoses have increased in recent years across North America, due to the potency of fentanyl its analogues, addition other substances, such as benzodiazepines. Facing with challenges opioid crisis, many American cities responded differently. These responses mainly focus on one field, medical care, law enforcement, judicature, social security. Among those community-based crisis response model Vancouver is worthy reference by cities. According ethnographic...
Oxymatrine, extracted from a traditional Chinese herb, Sophora flavescens Ait, has shown variety of pharmacological actions. Recently, we have proved that oxymatrine protected brain ischemic damage. However, little is known about the exact mechanisms this effect. This study to investigate potential neuroprotection and explore underlying mechanisms.Male Sprague-Dawley rats were subjected acute permanent middle cerebral artery occlusion (MCAO). Oxymatrine was administered immediately after...
Dexmedetomidine (DEX) as a nerve block adjuvant can significantly prolong analgesia. However, whether perineural or systemic administration of DEX is more beneficial in patients undergoing total knee arthroplasty (TKA) has not been thoroughly investigated. To this end, we evaluated the effects and on postoperative analgesia TKA surgery.We randomly assigned under general anesthesia combined with femoral sciatic to one three groups: (1) ropivacaine plus dexmedetomidine (DP): 0.25% 40 mL 0.5...
On-chip preconcentration, purification, and fluorescent labeling are desirable sample preparation steps to achieve complete automation in integrated microfluidic systems.
Objective Preterm birth (PTB) is a significant public health problem. We aimed to explore whether alpha fetal protein (AFP) or β-human gonadotropin (β-HCG) levels during pregnancy were associated with PTB in Chinese population. Study Design The clinical data collected Nanjing Medical University Affiliated Suzhou Hospital and Wuxi Maternity Child Health Care between January 2006 December 2011 analyzed retrospectively. A total of 64,999 pregnant women registered. In addition, 13,828 serum from...
Background: Both lumbosacral plexus block (LSPB) and local infiltration analgesia (LIA) can provide postoperative for patients undergoing total hip arthroplasty (THA). The current study aimed to compare the differences between LSPB LIA on pain quality of life (QoL) in THA patients. Methods: A 117 aged 40– 80 years, ASA I-III, were prospectively randomized into two groups: a general anesthesia plus (Group LSPB) LIA). Pain intensity opioid consumption recorded Within 72 hours after surgery....
Propofol and sevoflurane as frequently used general anesthetics can affect postoperative pain. Our study explored whether the incidence of pain differed among patients with chronic undergoing total knee arthroplasty (TKA) anesthetized or propofol.Patients were randomly assigned to groups receiving either (Group S, n = 50) propofol P, 47) for anesthesia maintenance during TKA. The incidences quality life (QoL) measured using EuroQol 5-Dimension (EQ-5D) scale at 1, 3, 7 days post-operation...
The inversion algorithm attracts much attention since it converts surface potential to the distribution of charges on solid insulation. charge for measurement was affected by both shape testing sample and experimental methods. This paper proposes a non-invasive measurement, which previously reported investigate during highvoltage application. As high voltage is applied one side dielectric film (charged surface) other (measured measured. based electrostatic simulation measured density charged...
Abstract Background Non‐invasive prenatal testing (NIPT) is routinely used in clinical practice for fetal trisomy screening, but low total cfDNA content and fraction (LFF) are two factors that affect the detection rate. Samples with or LFF usually end up “no‐call” results, followed by blood redraw re‐testing, which inconvenient pregnant women clinicians. Methods We created mock 21 (T21) samples to investigate effects of possible solutions increase their Results resulted decreased unique...