A5101731970- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Dialysis and Renal Disease Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Chronic Kidney Disease and Diabetes
- Gastric Cancer Management and Outcomes
- Intraocular Surgery and Lenses
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Renal and Vascular Pathologies
- Neural and Behavioral Psychology Studies
- Animal testing and alternatives
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Retinal Diseases and Treatments
- Blood Pressure and Hypertension Studies
The First Affiliated Hospital, Sun Yat-sen University
2012-2025
Zhongshan Hospital
2014-2025
Sun Yat-sen University
2014-2025
Hebei Medical University
2021-2025
Fudan University
2014-2025
Third Hospital of Hebei Medical University
2021-2025
Xingtai People's Hospital
2023-2025
Peking Union Medical College Hospital
2000-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2000-2025
Ministry of Education of the People's Republic of China
2022-2025
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify Skp2–macroH2A1 (mH2A1)–cyclin-dependent kinase 8 (CDK8) axis as a critical pathway these processes, deregulation of this is associated with human breast progression patient survival outcome. We showed that mH2A1 new substrate Skp2 SCF complex whose degradation promotes CDK8 gene protein expression....
PANoptosis is a newly-discovered cell death pathway that involves crosstalk and co-ordination between pyroptosis, apoptosis, necroptosis processes. However, the roles of PANoptosis-related genes (PRGs) in prognosis immune landscape colon cancer remain widely unknown. Here, we performed bioinformatics analysis expression data nineteen PRGs identified from previous studies clinical patients obtained TCGA GEO databases. Colon cases were divided into two PRG clusters, prognosis-related...
Diabetic kidney disease (DKD) is becoming the leading cause of chronic disease, especially in industrialized world. Despite mounting evidence has demonstrated that immunity and inflammation are highly involved pathogenesis progression DKD, underlying mechanisms remain incompletely understood. Substantial molecules, signaling pathways, cell types participate DKD inflammation, by integrating into a complex regulatory network. Most studies have focused on individual components, without...
Abstract Stress‐induced hair loss is a prevalent health concern, with mechanisms that remain unclear, and effective treatment options are not yet available. In this study, we investigated whether stress‐induced was related to an imbalanced immune microenvironment. Screening the skin‐infiltrated cells in stressed mouse model, discovered significant increase macrophages upon stress induction. Clearance of rescues mice from shedding depletion follicle stem (HFSCs) skin, demonstrating role...
Abstract Hyperkalaemia is an electrolyte imbalance that impairs muscle function and myocardial excitability, can potentially lead to fatal arrhythmias sudden cardiac death. The prevalence of hyperkalaemia estimated be 6%–7% worldwide 7%–10% in Asia. frequently affects patients with chronic kidney disease, heart failure, diabetes mellitus, particularly those receiving treatment renin‐angiotensin‐aldosterone system (RAAS) inhibitors. Both interruption RAAS inhibitor therapy are associated...
RESULTSSignificant differences were found in many more domains of the two questionnaires between mMRC grades than GOLD stages.In multiple linear regression model, scale was only factor that remained determinative all SGRQ and WHOQOL-BREF.Patients with chronic productive cough, sleep disorders frequent exacerbations had poorer HRQoL, as reflected by higher scores or lower WHOQOL-BREF. CONCLUSIONThe dyspnoea is a concise practical tool to assess HRQoL patients COPD daily clinical practice.
Pyroptosis and necroptosis are two recently identified forms of immunogenic cell death in the tumor microenvironment (TME), indicating a crucial involvement metastasis. However, characteristics pyroptosis that define prognosis ccRCC patients remain unknown. We systematically investigated transcriptional variation expression patterns Necroptosis related genes (NPRGs). After screening necroptosis-pyroptosis clusters, potential functional annotation for clusters was explored by GSVA enrichment...
ABSTRACT Background Late gadolinium enhancement (LGE) has been found in patients with autoimmune rheumatic disease (ARD). However, the prognostic implications of some specific LGE patterns ARD remain unclear. Purpose To investigate prevalence and significance left ventricular (LV) subendocardium‐involved (LGEse) a cohort patients. Materials Methods This retrospective study evaluated 176 diagnosed clinically suspected cardiac involvement between 2018 2023. LV LGEse was defined as involving...
Abstract Prostate cancer (PCa) is one of the most common malignancies for male individuals globally. Androgen deprivation therapy (ADT) initially demonstrated significant efficacy in treating PCa; however, cases PCa eventually progress to castration‐resistant prostate (CRPC), which becomes increasingly challenging manage. Notably, loss or disruption primary cilia cells may play a critical role progression disease, and there are no reports on circular RNAs ciliogenesis. Thus, this warrants...
Background: Endoscopic submucosal dissection (ESD) is the first-line treatment for gastric mucosal lesions. The artificial ulcers caused by ESD can lead to bleeding, perforation, and other adverse events. Objectives: This study aimed evaluate efficacy of alternate mucosa–submucosa clip in preventing events following Design: Multicenter retrospective observational study. Methods: Data from 924 patients who underwent lesions were retrospectively collected categorized into completely closed...
ABSTRACT Portal hypertension (PH) is a collection of clinical conditions that occur due to an enduring elevation pressure within the portal venous system, and it closely linked prognosis liver disease patients. The hepatic gradient (HVPG) considered diagnostic standard for PH, but its use limited invasive, costly, radiological nature. As such, search noninvasive methods focus researchers worldwide. This review article provides overview routine novel blood test indicators, as well models...
This study retrospectively analyzed 167 colorectal cancer patients from November 2013 to February 2021 in Zhongda Hospital of Southeast University, divided into liver metastasis group (37 cases) and no (130 cases), the data were training set test according 7:3. The constructed traditional clinical, imaging histology, pathohistology, TLS score multimodal integration models, screened features by LASSO regression. results showed that model had an AUC 0.94, accuracy 0.927, precision F1 scores...
Background Increasing evidence is showing that necroptosis has unique clinical significance in the occurrence and development of multiple diseases. Here, we systematically evaluate role clear cell renal carcinoma (ccRCC) analyze its regulatory patterns. Methods First, evaluated expression enrichment necroptotic factors ccRCC using gene set analysis (GSEA) survival profile from The Cancer Genome Atlas (TCGA) to demonstrate overall mutation pathway genes. Then, used unsupervised clustering...
Abstract Purpose This study aimed to investigate the incidence and associated risk factors of ischaemic muscle sequelae in patients with traumatic femoropopliteal artery injuries following revascularization, as well develop a nomogram predict sequelae. Methods Data from acute between January 2008 December 2022 were collected. All successful limb salvage divided into two groups based on occurrence sequelae: ischemic group (IG) non-ischaemic (NG). Univariate multivariate logistic regression...
Significance Caveolin-1 (Cav-1) is a major structural protein of caveolae found in cell membranes and critical for numerous cellular functions. However, it remains unclear whether Cav-1 plays role ocular neovascularization, cause blindness. In this study, we that the gene deletion exacerbates cavtratin, permeable peptide mimicking function, inhibits neovascularization by targeting multiple components angiogenesis. Importantly, combined administration cavtratin anti–VEGF-A more effectively,...
Tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a role in the excessive generation extracellular matrix liver fibrosis. This study aimed to explore pathways through which TIMP-1 controls monocyte chemoattractant protein-1 (MCP-1) expression and promotes hepatic macrophage recruitment.