A5066279331- Autophagy in Disease and Therapy
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Carcinogens and Genotoxicity Assessment
- Histone Deacetylase Inhibitors Research
- Heavy Metal Exposure and Toxicity
- Biochemical Acid Research Studies
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Toxic Organic Pollutants Impact
- Tea Polyphenols and Effects
- Nicotinic Acetylcholine Receptors Study
- Endoplasmic Reticulum Stress and Disease
- Vehicle emissions and performance
- Bioactive Compounds and Antitumor Agents
- Liver Disease Diagnosis and Treatment
China Medical University Hospital
2014-2024
China Medical University
2014-2024
National Cheng Kung University
2015-2024
Kaohsiung Medical University
2021-2022
Taipei Medical University
2010-2021
Asia University
2014-2018
The University of Texas MD Anderson Cancer Center
2013-2015
Taipei Medical University Hospital
2010
Cathay General Hospital
2010
Taipei Medical University-Shuang Ho Hospital
2010
Nanoparticles (NPs) have been used to produce a wide range of products that applications in imaging and drug delivery medicine. Due their chemical stability, well-controlled sizes surface charges, polystyrene (PS) NPs developed as biosensors carriers. However, the possible adverse biological effects underlying mechanisms are still unclear. Recently, autophagy has implicated regulation cell death. In this study, we evaluated library PS with different charges. We found NH2-labeled (NH2-PS)...
Large epidemiological cohort studies in the United States have indicated that active and passive smoking are associated with increased breast cancer risk. However, there was no direct evidence of an effect tobacco carcinogens on cellular molecules involved tumorigenesis.Reverse transcription-polymerase chain reaction used to determine expression all nicotinic acetylcholine receptor (nAChR) subunits 50 human samples alpha9-nAChR subunit 276 surgical laser capture microdissected tumor vs...
Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify Skp2–macroH2A1 (mH2A1)–cyclin-dependent kinase 8 (CDK8) axis as a critical pathway these processes, deregulation of this is associated with human breast progression patient survival outcome. We showed that mH2A1 new substrate Skp2 SCF complex whose degradation promotes CDK8 gene protein expression....
Zinc oxide nanoparticles (ZnONPs) are widely used nanomaterial in personal cosmetics, such as skin creams and sunscreens, due to their whitening properties strong UV light absorption. However, the safety issues hazards of ZnONPs, which can be taken up by cause toxicity, still unclear. From a chemoprevention point view, pterostilbene (PT) has been reported prevent damage effectively its anti-inflammatory autophagy inducer effect. This study aims determine toxicity potential mechanisms UVB...
In this study, human and rat cancer cells were used to investigate the expression of p53 p21/WAF1/CIP1 their association with apoptosis after exposure nitric oxide (NO). It was found that NO induced nuclear accumulation protein in a dose- time-dependent manner. The level elevated by about fivefold compared mock-treated 48 h 300 ppm NO. induction pulse-chase analysis be mainly regulated post-translational modification. correlation between status also investigated study. We easily containing...
Cigarette smoke is a major risk factor for bladder cancer. The main component in cigarette smoke, nicotine, can be detected the urine of smokers. Nicotine has been implicated as cocarcinogen that promotes lung cancer development through prosurvival pathways. Although mechanisms nicotine-induced cell proliferation have well studied epithelial cells, molecular mechanism its action cells still unclear. aims this study were to investigate whether there and identify signaling transduction pathway...
Rosmanol is a natural polyphenol from the herb rosemary (Rosmarinus officinalis L.) with high antioxidant activity. In this study, we investigated inhibitory effects of rosmanol on induction NO synthase (NOS) and COX-2 in RAW 264.7 cells induced by lipopolysaccharide (LPS). markedly inhibited LPS-stimulated iNOS protein gene expression, as well downstream products, PGE2. Treatment also reduced translocation nuclear factor-κB (NF-κB) subunits prevention degradation phosphorylation inhibitor...
Previous studies reported that peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) has antiproliferative and anti-inflammatory activities. Here, we evaluated the chemopreventive effects underlying molecular mechanisms of dietary administration AcEGCG EGCG in dextran sulfate sodium (DSS)-induced colitis mice. The mice were fed a diet supplemented with either or prior to DSS induction. Our results indicated was more effective than preventing shortening colon length formation aberrant crypt...
Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molecular mechanisms underlying ZnO NP nephrotoxicity remain unclear. In this study, we evaluated potential toxicity NPs kidney cells vitro vivo.We found that were apparently engulfed by HEK-293 human embryonic then induced reactive oxygen species (ROS) generation. Furthermore, exposure to...
As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about toxic effects nanomaterials, especially because unique physicochemical properties affect functional reactions. In our research, we sought identify targets mechanisms for deleterious two different sizes (~10 ~50 nm) amine-modified silver (AgNPs) a zebrafish...
Abstract Cellular senescence is characterized by permanent cell cycle arrest, triggered a variety of stresses, such as telomerase inhibition, and it recognized tumor-suppressor mechanism. In recent years, has become an important therapeutic target in several cancers; inhibition can induce via the DNA damage response (DDR). Pterostilbene (PT), dimethyl ether analog resveratrol, possesses biological functions, including anticancer effects; however, molecular mechanisms underlying these effects...
Chronic kidney disease (CKD) is recognized as a global public health problem. NLRP3 inflammasome activation has been characterized to mediate diverse aspect mechanisms of CKD through regulation proinflammatory cytokines, tubulointerstitial injury, glomerular diseases, renal inflammation, and fibrosis pathways. Autophagy negative mechanism in the inflammasome, which now key regulator pathogenesis inflammation CKD. Thus, autophagy undoubtedly an attractive target for developing new protective...