A5042888545- Monoclonal and Polyclonal Antibodies Research
- Venomous Animal Envenomation and Studies
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Rabies epidemiology and control
- Asthma and respiratory diseases
- Tryptophan and brain disorders
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Dental Implant Techniques and Outcomes
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Fungal Biology and Applications
- Dental materials and restorations
- Immune Response and Inflammation
- Bipolar Disorder and Treatment
- Nerve injury and regeneration
- Viral Infections and Immunology Research
- Allergic Rhinitis and Sensitization
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Immune cells in cancer
- Periodontal Regeneration and Treatments
- HIV Research and Treatment
Taipei Medical University
2016-2025
National Yang Ming University Hospital
2013-2018
National Yang Ming Chiao Tung University
2013-2018
University of California, Riverside
2014
E-Da Hospital
2014
National Changhua University of Education
2014
National Research Institute of Chinese Medicine
2014
Ministry of Health and Welfare
2014
I-Shou University
2014
Wan Fang Hospital
2010-2013
Background: There are clear interactions between chronic alcohol consumption and circadian rhythmicity that is regulated by several clock genes. The altered expressions of these genes have been mainly described in animals. mammalian master the suprachiasmatic nuclei orchestrates biological rhythms peripheral tissues. As blood mononuclear cells (PBMCs) most accessible tissue clinically, we assessed mRNA levels patients with dependence (AD) undergoing alcohol‐withdrawal (AW) treatment....
Monkeypox (mpox), a zoonotic disease, has rapidly spread globally, prompting the WHO to declare it public health emergency. The long incubation period, early symptoms resembling respiratory infections, and diagnostic challenges hinder timely epidemic control accurate clinical diagnosis. monkeypox virus (MPXV) encodes A29L protein, which binds cellular heparan sulfate facilitate infection serves as target for treatment diagnostics. Thus, developing effective tools treatments is critically...
ABSTRACT Staphylococcus aureus , a prevalent gram‐positive bacterium in human populations, poses significant risk for causing serious opportunistic infections and increasing antibiotic resistance. Alpha‐enolase S. plays important roles extracellular matrix binding biofilm formation. These functions enable to invade host tissues cause infections. The aim of this study was develop specific alpha‐enolase chicken antibodies through phage display technology targeting surface proteins as potential...
Many researches have been trying to find the potential biomarkers for Alzheimer’s disease (AD). We hereby used proteomics method search protein expression differences in serum between AD patients and controls. enrolled 59 74 age- sex-matched controls this study. Ten 10 were selected proteomic analysis. Apolipoprotein A-I (ApoA-I) was found a lower group by two-dimensional gel electrophoresis further measured ApoA-I level which significantly (112.29 ± 21.33 mg/dl) comparison (144.53 19.91...
Aims: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive process. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity and learning. In this study, we explored changes of serum BDNF levels alcoholic patients at baseline after one-week alcohol withdrawal. Methods: Twenty-five were admitted for detoxification treatment, 22 healthy control subjects also enrolled. We collected blood samples patient group on first seventh day withdrawal,...
Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)‐3, lithium, GSK‐3, are both prescribed in clinical as mood‐stabilizers anticonvulsants for the control of bipolar disorder. This study aims to compare immuno‐modulation activities VPA especially on differentiation functions dendritic cells (DC). Our data show that treatment or lithium effectively alleviated severity collagen‐induced arthritis triggered by LPS mice. Both...
Background: Brain-derived neurotrophic factor (BDNF) is associated with alcohol addiction and withdrawal-related neurotoxicity. Delirium tremens (DT) the most serious complication of withdrawal syndrome (AWS). In this study, we explored differences in serum BDNF levels, measured at baseline 1 week after among alcoholic patients without DT. Methods: Sixty-five inpatients, fulfilling DSM-IV criteria dependence admitted for detoxification, as well 39 healthy control subjects were enrolled. The...
This study investigated the immunomodulatory effects of ferulic acid (FA) on antigen-presenting dendritic cells (DCs) in vitro and its antiallergic against ovalbumin- (OVA-) induced Th2-mediated allergic asthma mice. The activation FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS) stimulation a high level interleukin- (IL-) 12 but reduced expression levels proinflammatory cytokines IL-1β, IL-6, tumor necrosis factor- (TNF-) α. Compared to control-treated DCs, FA significantly...
Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes DN. Hence, this study aimed further investigate the renal injury-reducing effect CmNo1, a novel combination powders fruiting bodies mycelia Cordyceps militaris. After being administered with streptozotocin-nicotinamide high-fat-diet, mouse model displayed elevated dysfunction markers...
Abstract Lithium has been used or explored to treat psychiatric and neurodegenerative diseases that are frequently associated with an abnormal immune status. It is likely lithium may work through modulation of responses in these patients. Because dendritic cells (DC) play a central role regulating responses, this study investigated the influence chloride (LiCl) on development function DC. Exposure LiCl during differentiation human monocyte‐derived immature DCs (iDC) enhances CD86 CD83...
Tyrosinase, a key copper-containing enzyme involved in melanin biosynthesis, is closely associated with hyperpigmentation disorders, cancer, and neurodegenerative diseases, as such, it an essential target medicine cosmetics. Known tyrosinase inhibitors possess adverse side effects, there are no safety regulations; therefore, necessary to develop new fewer effects less toxicity. Peptides exquisitely specific their vivo targets, high potencies relatively few off-target effects. Thus, we...
Snake venom protein from Deinagkistrodon acutus (DA protein), one of the major venomous species in Taiwan, causes hemorrhagic symptoms that can lead to death. Although horse-derived antivenin is a treatment, relatively strong and detrimental side effects are seen occasionally. In our study, yolk immunoglobulin (IgY) was purified eggs, DA recognized using Western blotting an enzyme-linked immunosorbent assay (ELISA), similar therapeutic horse antivenin. The ELISA also indicated specific IgY...
Cardamonin, the chalcone class, is one of natural components from spicy herbaceous plant (Alpinia conchigera Griff) and has anticancer activities in many human cancer cell lines. There is, however, no information to show that cardamonin induces apoptosis alters associated gene expressions mouse leukemia cells. Thus, we investigated effects on apoptotic death expression WEHI-3 cells vitro. Results indicated decreased total viable number via induced morphological changes were assay by...
Porphyromonas gingivalis infection is one of the causes implant failures, which can lead to peri-implantitis. Implant surface roughness reportedly related strongly P. adhesion, peri-implantitis and, later, cell adhesion. Our aim was evaluate effects Er,Cr:YSGG laser on titanium (Ti) disc surfaces and its interaction with bacterial adhesion fibroblast viability. Ti discs underwent two treatments: autoclaving (control) erbium, chromium-doped yttrium scandium gallium garnet (Er,Cr:YSGG)...
Abstract Type II collagen is known to modulate chondrogenesis of mesenchymal stem cells (MSCs). In this study, MSCs from human bone marrow aspirates were used study the modulating effects type on MSC differentiation during early stages osteogenesis and adipogenesis. With osteogenic induction, cultured collagen‐coated surface showed an enhanced calcium deposition level with increasing mRNA expressions RUNX2, osteocalcin, alkaline phosphatase. A synthetic integrin binding peptide, which...
The venom of the banded krait (Bungarus multicinctus), one major venomous species in Taiwan, contains neurotoxic proteins (B. multicinctus proteins) that pose a serious medical problem tropical and subtropical countries. Even though horse-derived serum is an efficient therapy against snake venom, it associated with high cost side effects. Therefore, developing more cost-effective alternative treatment option highly envisaged. In this study, chickens were immunized B. proteins, polyclonal...