A5007989945- Infections and bacterial resistance
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Plant Pathogenic Bacteria Studies
- Zoonotic diseases and public health
- Identification and Quantification in Food
- Microbial Fuel Cells and Bioremediation
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Neural Networks and Applications
- Microbial metabolism and enzyme function
- Virus-based gene therapy research
- Venomous Animal Envenomation and Studies
- Legume Nitrogen Fixing Symbiosis
- Cancer-related molecular mechanisms research
- Poxvirus research and outbreaks
- Yersinia bacterium, plague, ectoparasites research
- CRISPR and Genetic Engineering
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Advanced Algorithms and Applications
- Rabies epidemiology and control
Taipei Medical University
2022-2025
National Institute of Allergy and Infectious Diseases
2025
National Institutes of Health
2025
National Yang Ming Chiao Tung University
2022
Université du Québec à Montréal
2018-2019
Monkeypox (mpox), a zoonotic disease, has rapidly spread globally, prompting the WHO to declare it public health emergency. The long incubation period, early symptoms resembling respiratory infections, and diagnostic challenges hinder timely epidemic control accurate clinical diagnosis. monkeypox virus (MPXV) encodes A29L protein, which binds cellular heparan sulfate facilitate infection serves as target for treatment diagnostics. Thus, developing effective tools treatments is critically...
Abstract Bacterial pathogens can undergo striking adaptive evolutionary change in the context of infection, driven by selection forces associated with host defenses and antibiotic treatment. In this work, we analyze transcriptional landscape adaptation an emerging zoonotic pathogen, Bordetella hinzii , as it evolved during a 45-month infection IL12Rβ1-deficient immunocompromised host. We find evidence multiple niche-specific modifications intravascular gastrointestinal compartments,...
ABSTRACT Staphylococcus aureus , a prevalent gram‐positive bacterium in human populations, poses significant risk for causing serious opportunistic infections and increasing antibiotic resistance. Alpha‐enolase S. plays important roles extracellular matrix binding biofilm formation. These functions enable to invade host tissues cause infections. The aim of this study was develop specific alpha‐enolase chicken antibodies through phage display technology targeting surface proteins as potential...
Stenotrophomonas maltophilia, a nonfermenting Gram-negative rod, is frequently isolated from the environment and emerging as multidrug-resistant global opportunistic pathogen. S. maltophilia harbors eight RND-type efflux pumps that contribute to multidrug resistance physiological functions. Among pumps, SmeYZ pump constitutively highly expressed. In our previous study, we demonstrated loss-of-function of results in pleiotropic phenotypes, including abolished swimming motility, decreased...
, the Chinese cobra, is a major cause of snake envenomation in Asia, causing hundreds thousands clinical incidents annually. The current treatment, horse serum-derived antivenom, has unpredictable side effects and presents manufacturing challenges. This study focused on developing new-generation venom antidotes by using microbial phage display technology to derive nanobodies from an alpaca immunized with attenuated
Iron is an essential micronutrient for various bacterial cellular processes. Fur a global transcriptional regulator participating in iron homeostasis. Stenotrophomonas maltophilia ubiquitous environmental bacterium that has emerged as opportunistic pathogen. To elucidate the novel regulatory mechanism behind homeostasis S. maltophilia, wild-type KJ and KJΔFur, fur mutant, were subjected to transcriptome assay. A five-gene cluster, sbiBA-sbiTRS, was significantly upregulated KJΔFur. SbiAB ATP...
Porins of Gram-negative bacteria generally act as channels that allow the entry or extrusion molecules. Moreover, structural role porins in stabilizing outer membrane by interacting with peptidoglycan (PG) and has been proposed.
A method is described for enlarging as much possible the basin of attraction a Hopfield-type associative memory. The proposed learning rule, minimum-overlap algorithm that includes threshold parameter, enables memory to be designed so will have maximal attraction. technique diminishes effect on devised. Simulation results show constructed by indeed larger than several well known methods.
The emergence of the Next Generation Sequencing increases drastically volume transcriptomic data. Although many standalone algorithms and workflows for novel microRNA (miRNA) prediction have been proposed, few are designed processing large sequence data from genomes, even fewer further annotate functional miRNAs by analyzing multiple libraries. We propose an improved pipeline a high facility implementing mirLibSpark based on Apache Spark framework. This is fastest actual method, provides...
We report the draft genome sequence of Stenotrophomonas maltophilia strain KJ, which was isolated from a sputum sample patient with respiratory tract infection. Multilocus typing analysis suggested that KJ belongs to novel S. type.