A5014639690- Mosquito-borne diseases and control
- Vibrio bacteria research studies
- Viral Infections and Vectors
- Virology and Viral Diseases
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Plant Stress Responses and Tolerance
- Bioinformatics and Genomic Networks
- Enzyme Structure and Function
- Legionella and Acanthamoeba research
- Cancer-related Molecular Pathways
- Animal Virus Infections Studies
- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Plant Molecular Biology Research
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Plant Micronutrient Interactions and Effects
- Plant and Biological Electrophysiology Studies
The University of Texas MD Anderson Cancer Center
2021-2025
National Institutes of Health
2025
National Institute of Allergy and Infectious Diseases
2025
Johns Hopkins University
2001-2024
Johns Hopkins Medicine
2012-2024
University of Delhi
1987-2024
St. Xavier's College (Autonomous)
2001-2019
St Xavier’s College
2001-2019
Indian Institute of Science Bangalore
2010-2018
KIIT University
2014
Calcium (Ca2+) is an essential macronutrient as well a second messenger in diverse biological processes plants. Plants perceive various stimuli which leads to transient increase cytosolic calcium [Ca2+]cyt levels, resulting generation of Ca2+ signatures. These signatures are specific stress and developmental perceived by sensors. sensors relay proteins participate downstream signaling events decode the homeostasis involves synergistic action transporting elements that regulate influx efflux....
Vacuolar pathogens reside in membrane-bound compartments within host cells. Maintaining the integrity of this compartment is paramount to bacterial survival and replication as it protects against certain surveillance mechanisms that function eradicate invading pathogens. Preserving during requires expansion vacuole membrane accommodate increasing number bacteria, yet, how accomplished remains largely unknown. Here, we show vacuolar pathogen Legionella pneumophila exploits multiple sources...
Human papillomavirus (HPV)-driven cancers include head and neck squamous cell carcinoma cervical cancer represent approximately 5% of all cases worldwide. Standard-of-care chemotherapy, radiotherapy, immune checkpoint inhibitors (ICIs) are associated with adverse effects limited responses in patients HPV-driven cancers. The integration targeted therapies ICIs may improve outcomes. In a previous study, we demonstrated that Aurora kinase A (AURKA, A) lead to apoptosis human HPV-positive cells...
Abstract Bacterial pathogens can undergo striking adaptive evolutionary change in the context of infection, driven by selection forces associated with host defenses and antibiotic treatment. In this work, we analyze transcriptional landscape adaptation an emerging zoonotic pathogen, Bordetella hinzii , as it evolved during a 45-month infection IL12Rβ1-deficient immunocompromised host. We find evidence multiple niche-specific modifications intravascular gastrointestinal compartments,...
A panel of monoclonal antibodies (MAbs) raised against an Indian strain Japanese encephalitis (JE) virus was used to map topographically the epitopes on envelope protein. Two separate clusters were revealed. On basis reactivity in haemagglutination inhibition (HI), neutralization (NT), passive protection and antibody-dependent plaque enhancement (ADPE) assays with MAbs, five functional domains (A, B, C, D E) delineated. The flavivirus cross-reactive domain for HI (A) distinct. JE...
Like the p16, SMAD4, and RB1 genes, FAM190A (alias CCSER1) lies at a consensus site of homogeneous genomic deletions in human cancer. transcripts 40% cancers also contain in-frame evolutionarily conserved exons. Its gene function was unknown. We found an internal deletion pancreatic cancer having prominent focal multinuclearity. The experimental knockdown expression by shRNA caused cytokinesis defects, multipolar mitosis, multinuclearity as observed time-lapse microscopy. localized to...
Protein structure space is believed to consist of a finite set discrete folds, unlike the protein sequence which astronomically large, indicating that proteins from available are likely adopt one many folds already observed. In spite extensive sequence–structure correlation data, prediction still remains an open question with researchers having tried different approaches (experimental as well computational). One challenges identify native structures milieu decoys/models. this work, rigorous...
Abstract Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test strengths and weaknesses their computational methods. CASP has significantly advanced field but many hurdles still remain, which may require new ideas collaborations. In 2012 a web-based effort called WeFold, was initiated promote collaboration within community attract researchers from other fields contribute CASP. Members WeFold coopetition...
Metalloproteins form a major class of enzymes in the living system that are involved crucial biological functions such as catalysis, redox reactions and 'switches' signal transductions. Iron dependent repressor (IdeR) is metal-sensing transcription factor regulates free iron concentration Mycobacterium tuberculosis. IdeR also known to promote bacterial virulence, making it an important target field therapeutics. Mechanistic details how ions modulate dimerizes binds DNA not understood...
Legionella pneumophila is an intracellular bacterial pathogen that replicates in alveolar macrophages, causing a severe form of pneumonia. Intracellular growth the bacterium depends on its ability to sequester iron from host cell. In L. strain 130b, one mechanism used acquire this essential nutrient siderophore legiobactin. Iron-bound legiobactin imported by transport protein LbtU. Here, we describe role LbtP, paralog LbtU, acquisition Philadelphia-1. Similar LbtP and required for robust...
Plant growth and development are governed by selective protein synthesis degradation. Ubiquitination mediated degradation is activating enzyme E1 followed conjugating E2 E3 ligase. Armadillo (ARM) repeat/U-box (PUB) family one of the important classes We studied function AtPUB2 loss-of-function (knockout knock down mutants) gain-of-function (CaMV 35S promoter driven overexpression lines) approach in Arabidopsis. Under normal condition, we observed that mutant plants did not show any...
The set of indispensable genes that are required by an organism to grow and sustain life termed as essential genes. There is a strong interest in identification the genes, particularly pathogens, not only for better understanding pathogen biology, but also identifying drug targets minimal gene organism. Essentiality inherently systems property requires consideration system whole their identification. available experimental approaches capture some aspects each method comes with its own...