A5034758526- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Bacterial Infections and Vaccines
- Marine Invertebrate Physiology and Ecology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Healthcare and Venom Research
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Bioactive Natural Diterpenoids Research
- Vector-Borne Animal Diseases
- Vector-borne infectious diseases
- Pneumonia and Respiratory Infections
- Ion channel regulation and function
- Streptococcal Infections and Treatments
- Antimicrobial Peptides and Activities
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Mycobacterium research and diagnosis
- Veterinary medicine and infectious diseases
Taipei Veterans General Hospital
2020-2025
National Tsing Hua University
2007-2024
National Defense Medical Center
2017-2024
National Changhua University of Education
2023
Taichung Veterans General Hospital
2020-2022
National Chung Hsing University
2022
National Yang Ming Chiao Tung University
2020-2021
Boehringer Ingelheim (United States)
2020
National Health Research Institutes
2015-2017
Ministry of Health and Welfare
2015-2016
Background: Naja atra snakebite is uncommon in Taiwan and causes distinct effects on its victims. Although the government produces own specific antivenom, little information management of N. available.Materials methods: We retrospectively evaluated 183 patients admitted to two medical centers. Of these, 45 were identified as definite cases snakebite, 86 suspected cases, 52 clinical cases. Demographic data, symptomatology, compared between these case groups.Results: Symptomatology similar...
ABSTRACT Staphylococcus aureus , a prevalent gram‐positive bacterium in human populations, poses significant risk for causing serious opportunistic infections and increasing antibiotic resistance. Alpha‐enolase S. plays important roles extracellular matrix binding biofilm formation. These functions enable to invade host tissues cause infections. The aim of this study was develop specific alpha‐enolase chicken antibodies through phage display technology targeting surface proteins as potential...
Enterovirus 71 (EV71) has caused several epidemics of hand, foot and mouth diseases (HFMD) in Asia now is being recognized as an important neurotropic virus. Effective medications prophylactic vaccine against EV71 infection are urgently needed. Based on the success inactivated poliovirus vaccine, a prototype chemically candidate been developed currently human phase 1 clinical trial.In this report, we present development serum-free cell-based vaccine. The optimization at each step...
Abstract Significant health risks are posed by meningitis due to its rapid progression, and challenges encountered in intravenous antibiotic administration, especially crossing the blood‐brain barrier. To address this, an inflammation‐activated, endogenous macrophage (MΦ)‐mediated oral prodrug delivery system is developed for targeted therapeutic interventions bacterial treatment. This guided inflammation‐derived chemoattractants triggers drug release through inflammation‐induced reactive...
Although specific antivenom is available in Taiwan, respiratory failure and general pain frequently accompany Bungarus multicinctus envenomation there have been few reports on the management of B. envenomation. We retrospectively analyzed 44 cases bite admitted to Taichung Veterans General Hospital (VGH) or Taipei VGH. Demographic data, treatment, outcome patients with without were compared. In this study, 20.5% had bites noticeable signs symptoms significant envenoming, 27.3% developed...
Deinagkistrodon acutus envenomation is associated with severe hematological and wound complications but rarely described.Herein, we report three cases of victims bitten by D. indicate that rapid-onset coagulopathy thrombocytopenia are distinct features snakebite, which not observed in other crotaline snakebites (i.e., Trimeresurus stejnegeri Protobothrops mucrosquamatus) Taiwan. The toxic effects could occur as early 2 to 3 h following persist if the administration specific antivenom delayed...
Introduction Protobothrops mucrosquamatus bite induces wound necrosis, coagulopathy, thrombocytopenia, rhabdomyolysis, and acute renal failure. The severity of the hematological derangements associated factors for necrosis subsequent surgery appropriate management these conditions have not been well characterized. Although severe failure requiring hemodialysis has reported following P. bite, culprit snake may be erroneously classified.Materials methods A total 186 patients with bites were...
Abstract Objective —To develop a method to experimentally induce Borrelia burgdorferi infection in young adult dogs. Animals —22 healthy Beagles. Procedure —All dogs were verified be free of borreliosis. Twenty 6-month-old exposed -infected ticks and treated with dexamethasone for 5 consecutive days. Two not served as negative-control Clinical signs, results microbial culture polymerase chain reaction (PCR) testing, immunologic responses, gross histologic lesions evaluated 9 months after...
The electric properties of ferroelectric BiFeO3 (BFO) thin films with ZrO2 insulating buffer on Si substrates fabricated by chemical solution deposition were investigated. demonstrates excellent substrates. metal-ferroelectric-insulator-semiconductor (MFIS) structure exhibits clockwise capacitance-voltage hysteresis loops due to the polarization BFO. maximum memory windows are 0.66 and 0.78V, respectively, for BFO deposited postannealed unannealed layers. small window BFO∕ZrO2 (postannealed)...
Background: Trimeresurus stejnegeri bite induces tissue swelling, pain, thrombocytopenia, rhabdomyolysis, and acute renal failure. However, the incidence of coagulopathy, factors associated with wound necrosis, appropriate management this condition have not been well characterized yet. Materials: This study included patients bitten by T. s. that were admitted to hospitals from 2001 2016. Patient characteristics, laboratory data, approaches compared in victims without necrosis. Results: A...
Zika virus (ZIKV) is a new and emerging that has caused outbreaks worldwide. The been linked to congenital neurological malformations in neonates Guillain–Barré syndrome adults. Currently there are no effective vaccines available. As result, great need for ZIKV treatment. In this study, we developed single chain variable fragment (scFv) antibodies target the envelope protein using phage display technology. We first induced an immune response white leghorn laying hens against (E) protein....
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer that widely used to enhance the flexibility and durability of various products. As an endocrine disruptor, DEHP can interfere with normal hormonal functions, posing substantial health risks organisms. Given critical role liver in metabolism, we investigated potential damage offspring induced by prenatal exposure low doses Sprague Dawley rats. Pregnant rats were divided into three groups administered 20 or 200 μg/kg/day corn oil vehicle...
, the Chinese cobra, is a major cause of snake envenomation in Asia, causing hundreds thousands clinical incidents annually. The current treatment, horse serum-derived antivenom, has unpredictable side effects and presents manufacturing challenges. This study focused on developing new-generation venom antidotes by using microbial phage display technology to derive nanobodies from an alpaca immunized with attenuated
"Haemophilus somnus" fractions which inhibited iodination of protein by bovine polymorphonuclear leukocytes were isolated heat extracting a washed bacterial suspension at 60 degrees C or incubating the 37 and partially purified ultrafiltration. The components in each fraction separated reverse-phase high-performance liquid chromatography identified as ribonucleotides, ribonucleoside, purine pyrimidine bases. Most compounds found to be inhibitory dose-dependent manner. When effect component...
Tapai is a well-known indigenous fermented alcoholic beverage among Kadazan-Dusun-Murut (KDM) ethnics during festive occasions and gatherings in East Malaysia.Unfortunately, very little research has been done on this beverage.The objective of study was to identify functional microfloras involved the production tapai.Samples from local producers were obtained for microbiological proximate analysis.The fermentation process predominated by yeasts lactic acid bacteria (LAB) with initial numbers...
The influence of recombinant bovine interferon gamma (rBoIFN-gamma) treatment on resistance clinically normal and dexamethasone-treated calves to Haemophilus somnus infection was evaluated. Four groups 6 each were treated with saline solution (controls), dexamethasone (0.04 mg/kg body weight/for 3 days), rBoIFN-gamma (2 micrograms/kg for 2 or (aforementioned dosages). All treatments started 24 hours before intrabronchial challenge exposure 5 x 10(9) colony-forming units H somnus. Rectal...
The objective of this study was to develop an intestinal model Mycobacterium avium subspecies paratuberculosis ( Map) infection in the calf for evaluation mucosal pathology and local systemic immunologic responses. Map inoculated into Peyer’s patches young calves using a right flank surgical approach standing exteriorize ileocecal junction. Inoculum doses ranging from 10 3 9 colony-forming units strain K10 were injected through serosal surface distal ileum near valve. Fecal samples collected...