A5043298435- Animal Disease Management and Epidemiology
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Microbial infections and disease research
- Cardiac electrophysiology and arrhythmias
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- T-cell and Retrovirus Studies
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atrial Fibrillation Management and Outcomes
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Aquaculture disease management and microbiota
- Reproductive Physiology in Livestock
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
Iowa State University
2013-2024
Medical College of Wisconsin
2004-2022
Albany Medical Center Hospital
2021
Inspection Technologies (United Kingdom)
2014
George Washington University
2012
Advisory Board Company (United States)
2012
Ames National Laboratory
2011
Animal and Plant Health Inspection Service
1995-2009
Center for Epidemiology and Animal Health
2009
Elkhart Clinic
2006
SUMMARY Neutrophils from 8 Holstein heifers were evaluated for function during the periparturient period. Random migration ingestion of bacteria, superoxide anion production, native (nonenhanced) chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity by neutrophils determined. Foremilk samples bacteria. Significant ( P < 0.05) increases in random neutrophils, chemiluminescence evident 2 weeks before parturition then decreased dramatically first week after...
SUMMARY Lymphocytes from 8 Holstein heifers were evaluated during the periparturient period for mitogen-induced lymphocyte blastogenic responses. Phytohemagglutinin P- and concanavalin A-induced blastogenesis increased 2 3 weeks before parturition, respectively. However, by first week after was markedly impaired.
ABSTRACT Nipah virus (NiV), of the family Paramyxoviridae , was isolated in 1999 Malaysia from a human fatality an outbreak severe encephalitis, when infections were linked to transmission pigs. Consequently, swine vaccine able abolish shedding is veterinary and health interest. Canarypox virus-based vectors carrying gene for NiV glycoprotein (ALVAC-G) or fusion protein (ALVAC-F) used intramuscularly immunize four pigs per group, either with 10 8 PFU each combination. Pigs boosted 14 days...
The objective of this report was to characterize the enhanced clinical disease and lung lesions observed in pigs vaccinated with inactivated H1N2 swine δ-cluster influenza A virus challenged pandemic 2009 A/H1N1 human virus. Eighty-four, 6-week-old, cross-bred were randomly allocated into 3 groups 28 represent vaccinated/challenged (V/C), non-vaccinated/challenged (NV/C), non-vaccinated/non-challenged (NV/NC) control groups. Pigs intratracheally inoculated pH1N1and euthanized at 1, 2, 5, 21...
Veterinary vaccines have had, and continue to have, a major role in protecting animal health public health, reducing suffering, enabling efficient production of food animals feed the burgeoning human population, greatly need for antibiotics treat companion animals. Prominent examples include rabies rinderpest vaccines. Rabies domestic wildlife nearly eliminated developed countries. Thanks Global Rinderpest Eradication Program which involves vaccination, trade restrictions, surveillance, may...
Eighty 3-week-old crossbred pigs were randomly assigned to six groups (13–14 pigs/group). Group 1 served as uninoculated controls, group 2 inoculated intranasally (IN) with Streptococcus suis serotype 2, 3 IN a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine, 4 the same vaccine S. suis, 5 VR-2385 (a high-virulence strain of PRRSV), 6 suis. Pigs exposed both PRRSV 7 days prior inoculation. The 26 old when Respiratory disease was significantly more severe in...
Vaccine adjuvants are chemicals, microbial components, or mammalian proteins that enhance the immune response to vaccine antigens. Interest in reducing vaccine-related adverse effects and inducing specific types of immunity has led development numerous new adjuvants. Adjuvants experimental commercial vaccines include aluminum salts (alum), oil emulsions, saponins, immune-stimulating complexes (ISCOMs), liposomes, microparticles, nonionic block copolymers, deriv-atized polysaccharides,...
The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals BIV R29-infected cells seroconverted by 6 weeks postinoculation, and was recoverable from each animal at 2 postinoculation. However, levels replication vivo appeared to be low. In situ hybridization studies indicated that during peak periods viral vivo, less than 0.03% peripheral blood mononuclear expressing detectable RNA. Moreover, the RNA these...
SUMMARY Effects of a modified live vaccine ( mlv ) strain bovine viral diarrhea virus bvd on lymphocyte and neutrophil function were determined in cattle with without increased plasma cortisol (hydrocortisone) concentrations. Cattle given mlv-bvd im intranasally. ACTH received 200 IU every 12 hours for 10 doses. The when administered alone caused no apparent clinical signs or body temperature response. Of 4 -treated calves that also ACTH, 2 developed respiratory distress. decrease...
SUMMARY Recent decades have seen substantial expansions in the global air travel network and rapid increases traffic volumes. The effects of this are well studied terms spread directly transmitted infections, but role movement vector-borne diseases is less understood. Increasingly however, wider reaching surveillance for our improving abilities to map distributions vectors they carry, providing opportunities better understanding impact increasing travel. Here we examine trends continued...
Members of the National Science Advisory Board for Biosecurity explain its recommendations on communication experimental work H5N1 influenza.
Porcine reproductive and respiratory syndrome virus (PRRSV) infection induces interleukin (IL)-10 production increased numbers of PRRSV-specific regulatory T-lymphocytes in infected pigs. In the present study, roles nucleocapsid (N) protein induction IL-10 CD4 + CD25 Foxp3 lymphocytes (T reg ) were investigated. Transfection porcine monocyte-derived dendritic cells (MoDCs) pulmonary alveolar macrophages (PAMs) with a plasmid encoding N resulted significant upregulation gene expression...