A5066070289- Antibiotic Resistance in Bacteria
- Bacterial Genetics and Biotechnology
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacteriophages and microbial interactions
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Escherichia coli research studies
- DNA Repair Mechanisms
- Bacterial biofilms and quorum sensing
- Antimicrobial agents and applications
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Hematopoietic Stem Cell Transplantation
- Genomics and Phylogenetic Studies
- Plant Pathogenic Bacteria Studies
- Climate Change and Geoengineering
- Climate Change Policy and Economics
- Mycobacterium research and diagnosis
- Essential Oils and Antimicrobial Activity
- DNA and Nucleic Acid Chemistry
- Bacterial Identification and Susceptibility Testing
- RNA and protein synthesis mechanisms
- Legume Nitrogen Fixing Symbiosis
Gamida Cell (Israel)
2021-2024
National Center for Supercomputing Applications
2023-2024
University of Illinois Urbana-Champaign
2023-2024
Federation University
2018-2023
Tufts University
2009-2018
Boston University
1972-2016
Paratek Pharmaceuticals (United States)
2003-2015
Monash University
1997-2013
Advisory Board Company (United States)
2012
British Society for Antimicrobial Chemotherapy
2011
Organisms resistant to antimicrobials continue emerge and spread. This study was performed measure the medical societal cost attributable antimicrobial-resistant infection (ARI).A sample of high-risk hospitalized adult patients selected. Measurements included ARI, total cost, duration stay, comorbidities, acute pathophysiology, Acute Physiology Chronic Health Evaluation III score, intensive care unit surgery, health care-acquired infection, mortality. Hospital services used outcomes were...
Tetracycline resistance encoded by four genetically different determinants residing on plasmids in Escherichia coli was shown to be associated each case with an energy-dependent decrease accumulation of the antibiotic whole cells which had been induced. The class examined were those RP1 (class A), R222 B), R144 C), and RA1 D). This attributable active efflux, because everted (inside-out) membrane vesicles made from tetracycline-induced E. containing any one concentrate tetracycline influx....
Antibiotic resistance has become a major clinical and public health problem within the lifetime of most people living today. Confronted by increasing amounts antibiotics over past 60 years, bacteria have responded to deluge with propagation progeny no longer susceptible them. While it is clear that are pivotal in selection bacterial resistance, spread genes resistant also contributes problem. Selection forms can occur during or after antimicrobial treatment; antibiotic residues be found...
Pseudomonas fluorescens are common soil bacteria that can improve plant health through nutrient cycling, pathogen antagonism and induction of defenses. The genome sequences strains SBW25 Pf0-1 were determined compared to each other with P. Pf-5. A functional genomic in vivo expression technology (IVET) screen provided insight into genes used by its natural environment an improved understanding the ecological significance diversity within this species.
1. Summary, 65S 2. Introduction, 3. Efflux, 3.1. Tetracycline‐resistant bacteria, 66S 3.2. Tet proteins, 3.3. Efflux blocking, 67S 4. Regulation of multidrug efflux, 68S 5. Resistance to biocides, 69S 6. Conclusions, 70S 7. References, Energy‐driven drug efflux systems are increasingly recognized as mechanisms antibiotic resistance. Chromosomally located or acquired by they can either be activated environmental signals a mutation in regulatory gene. Two major categories exist: those...
A 7.8-kbp fragment of chromosomal DNA from a region controlling multiple antibiotic resistance (Mar) in Escherichia coli has been sequenced. Within the is potential divergent promoter including marO, which contains two pairs direct repeats, suggesting possible operator-regulatory sites. To left marO (region I) are one or transcriptional units with three putative open reading frames (ORFs) encoding 64, 157, and 70 amino acids. right II) unit containing ORFs (ORF125/144, ORF129, ORF72). Of six...
Chromosomal multiple-antibiotic-resistant (Mar) mutants of Escherichia coli, selected on agar containing low concentrations tetracycline or chloramphenicol, were 6- to 18-fold less susceptible the fluoroquinolones than their wild-type E. coli K-12 C parental strains. The frequency emergence such was at least 1,000-fold higher that those by fluoroquinolone norfloxacin directly. When Mar mutants, but not cells, plated norfloxacin, resistant high levels (2 micrograms/ml) appeared a relatively...
Increasing levels of resistance to tetracycline and a number other unrelated antibiotics, including chloramphenicol, beta-lactams, puromycin, nalidixic acid, occurred in Escherichia coli after 50 200 generations growth the presence subinhibitory concentrations or chloramphenicol. In absence selective pressure, resistances fell low within 100 growth. This amplification was observed laboratory naturally occurring E. strains as well polA recA strains. With exception previously identified cmlA...
A prospective study was undertaken to determine whether feeding farm animals antibiotics in feed caused changes the intestinal bacterial flora of dwellers and their neighbors. Chickens were fed tetracycline-supplemented (tet-feed), and, as expected, within one week contained almost entirely tetracycline-resistant organisms. Increased numbers resistant bacteria also appeared, but more slowly, members, not Within five six months, 31.3 per cent weekly fecal samples from greater than 80 compared...
The dwindling supply of new antibiotics largely reflects regulatory and commercial challenges, but also a failure discovery. In the 1990s pharmaceutical industry abandoned its classical ways seeking instead adopted strategy that combined genomics with high-throughput screening existing compound libraries. Too much emphasis was placed on identifying targets molecules bound to them, too little ability these permeate bacteria, evade efflux avoid mutational resistance; moreover, libraries were...