A5002616081- Antibiotic Use and Resistance
- Patient Satisfaction in Healthcare
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pharmaceutical Practices and Patient Outcomes
- Central Venous Catheters and Hemodialysis
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Antibiotic Resistance in Bacteria
- Emergency and Acute Care Studies
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Healthcare Systems and Technology
- Antimicrobial Resistance in Staphylococcus
- Epilepsy research and treatment
- Primary Care and Health Outcomes
- Innovations in Medical Education
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Drug Transport and Resistance Mechanisms
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Safe Handling of Antineoplastic Drugs
- Nursing Roles and Practices
National Health Service
2023-2025
NHS England
2022-2024
Public Health England
2023-2024
Portsmouth Hospitals NHS Trust
2022-2024
Government of the United Kingdom
2023
NHS Digital
2023
University of Southampton
2008-2022
Faculty of Public Health
2020
University Hospital Southampton NHS Foundation Trust
2012-2019
Department of Health and Social Care
2019
The dwindling supply of new antibiotics largely reflects regulatory and commercial challenges, but also a failure discovery. In the 1990s pharmaceutical industry abandoned its classical ways seeking instead adopted strategy that combined genomics with high-throughput screening existing compound libraries. Too much emphasis was placed on identifying targets molecules bound to them, too little ability these permeate bacteria, evade efflux avoid mutational resistance; moreover, libraries were...
ObjectivesTo evaluate the development of pharmacist-led antimicrobial stewardship activities in English hospitals.
Abstract Objectives Appropriate use of and access to antimicrobials are key priorities global strategies combat antimicrobial resistance (AMR). The WHO recently classified antibiotics into three categories (AWaRe) improve (Access), monitor important (Watch) preserve effectiveness ‘last resort’ (Reserve). This classification was assessed for antibiotic stewardship quality improvement in English hospitals. Methods Using an expert elicitation exercise, used England but not included the AWaRe...
The original and successful business model of return on investment being sufficiently attractive to the pharmaceutical industry encourage development new antibacterial molecules related diagnostics has been compromised by increasing costs regulatory hurdles, resulting in a decreasing chance success financial return. supply effective agents is diminishing along with number companies engaged research development. BSAC Working Party Urgent Need:Regenerating Antibacterial Drug Discovery...
Objective To investigate the effect of covid-19 pandemic on number patients with group A streptococcal infections and related antibiotic prescriptions. Design Retrospective cohort study in England using OpenSAFELY-TPP. Setting Primary care practices that used TPP SystmOne software, 1 January 2018 to 31 March 2023, approval NHS England. Participants Patients registered at a practice start each month period. missing data for sex or age were excluded, resulting population 23 816 470 2018,...
Abstract Background MPFT include medics, pharmacists, physician associates and dental professions. Trainees frequently see cases of sepsis, urinary tract infection (UTI) community acquired pneumonia (CAP); there are opportunities to introduce AMS learning into the optimal management these infections. A hub event was delivered by NHSE team in 2023 a hybrid format. Three case studies quality improvement (QI) presentation were delivered. Feedback positive but suggested more interactivity e.g....
Background: Approximately 71% of antibiotics in England are prescribed general practice settings. Whilst there various impactful training resources available to support clinicians antimicrobial stewardship (AMS) activities, implementation, reach, and uptake affect how successful they nationally. This case study explores the feasibility, acceptability, usefulness embedding TARGET (Treat Antibiotics Responsibly, Guidance, Education Tools) AMS into a local incentive scheme. Method: Black...
Objectives Antibiotics are effective in treating bacterial infections, but they carry the risks of antimicrobial resistance and effectiveness loss. This study aimed to assess whether antibiotics for common infections prescribed a risk-based manner how this changed during COVID-19 pandemic. Design Cohort antibiotic prescribing. Setting With approval NHS England, we accessed pseudonymised patient-level electronic health records primary care data from The Phoenix Partnership through OpenSAFELY....
Strategies to reduce antibiotic overuse in hospitals depend on prescribers taking decisions stop unnecessary use. There is scarce evidence for how support these decisions. We evaluated a multifaceted behaviour change intervention (ie, the review kit) designed use among adult acute general medical inpatients by increasing appropriate antibiotics at clinical review.We performed stepped-wedge, cluster (hospital)-randomised controlled trial using computer-generated sequence randomisation of...
Antimicrobial Stewardship (AMS) requires effective teamwork between healthcare professionals, with patients receiving consistent messages from all professionals on the appropriate antimicrobial use. Patient education may reduce patients’ expectations to receive antibiotics for self-limiting conditions and pressure primary care clinicians prescribe antibiotics. The TARGET Antibiotic Checklist is part of national AMS resources aims support interaction community pharmacy teams prescribed...
The COVID-19 pandemic impacted the healthcare systems, adding extra pressure to reduce antimicrobial resistance. Therefore, we aimed evaluate changes in antibiotic prescription patterns after started.
Abstract By using [ 11 C]flumazenil‐positron emission tomography ([ C]FMZ‐PET), we have previously shown that reductions of central benzodiazepine receptors (cBZRs) are restricted to the hippocampus in mesial temporal lobe epilepsy (mTLE) caused by unilateral hippocampal sclerosis (HS). Receptor autoradiographic studies on resected specimens from same patients demonstrated loss cBZRs was over and above neurons CA1 subregion. Here, report first direct comparison vivo cBZR binding with...
To describe the methodology in developing an antimicrobial self-assessment toolkit (ASAT). The ASAT was developed through a National Pharmacy Reference Group using evidence-based approach of published information and national reports to identify criteria for inclusion. These were subdivided into domains that addressed: Antimicrobial management within Trust—structures lines responsibility accountability—high-level notification Board. Operational delivery strategy—operational standards good...
The objective of this study was to establish how antibiotic prescribing policies at National Health Service (NHS) hospitals match the England Department 'Start Smart-Then Focus' recommendations and relate Clostridium difficile infection (CDI) rates.Antibiotic pharmacists were surveyed regarding for empirical treatment common syndromes ('Start Smart') antimicrobial prescription reviews ('Focus') their hospital trusts. If no response provided, policy data sought from trust websites MicroGuide...
BackgroundIdentifying potential risk factors related to severe COVID-19 outcomes is important. Repeated intermittent antibiotic use known be associated with adverse outcomes. This study aims examine whether prior frequent exposure outcomes.MethodsWith the approval of NHS England, we used OpenSAFELY platform, which integrated primary and secondary care, test, death registration data. matched case–control included 0.67 million patients (aged 18–110 years) from an eligible 2.47 incident by...
BACKGROUND: The study compared a new urinary hormone monitoring system, Clearview Primera Fertility Monitor® (CPFM), with laboratory analyses in the prediction of potentially fertile period. METHODS: Thirty healthy female volunteers provided blood and early morning urine samples for one cycle. Serum oestradiol, progesterone luteinizing (LH), LH oestrone-3-glucuronide (E3G) were measured. fertility status volunteers; Low, High or Peak, was collected from monitors measurements. RESULTS: There...
1. The gamma-aminobutyric acid (GABA)A/central benzodiazepine receptor (cBZR) complex is a major inhibitory in the vertebrate CNS. Binding of [11C]-flumazenil to this vivo reduced hippocampal sclerosis (HS). It has been uncertain whether cBZR binding entirely due neuronal loss HS. 2. objective study was characterize abnormalities HS with correlative autoradiographic and quantitative neuropathological study. 3. Saturation studies were performed [3H]-flumazenil investigate relationships...
This study aimed to predict risks of potentially inappropriate antibiotic type and repeat prescribing assess changes during COVID-19.
There is concern that the COVID-19 pandemic altered management of common infections in primary care. This study aimed to evaluate infection-coded consultation rates and antibiotic use during how any change may have affected clinical outcomes. With approval NHS England, a retrospective cohort using OpenSAFELY platform analysed routinely collected electronic health data from GP practices England between January 2019 December 2021. Infection coded consultations prescriptions were used estimate...