A5036375187- Infection Control and Ventilation
- Respiratory viral infections research
- Infection Control in Healthcare
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Vaccine Coverage and Hesitancy
- Nosocomial Infections in ICU
- Patient Satisfaction in Healthcare
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- Food Safety and Hygiene
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Viral-associated cancers and disorders
- Medical Device Sterilization and Disinfection
University of Hong Kong
2016-2025
Hong Kong Baptist Hospital
2013-2020
Institute for Clinical Evaluative Sciences
2018
Hospital for Sick Children
2018
SickKids Foundation
2018
Hospital Authority
2008-2015
Asia Pacific Satellite (South Korea)
2015
World Health Organization - Pakistan
2011-2014
Queen Mary Hospital
2003-2012
Queen Mary University of London
2003-2010
Information on the clinical features of severe acute respiratory syndrome (SARS) will be value to physicians caring for patients suspected having this disorder. We abstracted data presentation and course disease in 10 epidemiologically linked Chinese (5 men 5 women 38 72 years old) whom SARS was diagnosed between February 22, 2003, March at our hospitals Hong Kong, China. Exposure source patient subsequent ranged from minimal that health care provider. The incubation period 2 11 days. All...
The main route of transmission SARS CoV infection is presumed to be respiratory droplets. However the virus also detectable in other body fluids and excreta. stability at different temperatures relative humidity on smooth surfaces were studied. dried retained its viability for over 5 days 22–25°C 40–50%, that is, typical air-conditioned environments. However, was rapidly lost (>3 log 10 ) higher (e.g., 38°C, >95%). better coronavirus low temperature environment may facilitate community...
A large number of infectious diseases are believed to be transmitted between people via droplets and by airborne routes. An understanding evaporation dispersion droplet nuclei is not only significant for developing effective engineering control methods but also exploring the basic transmission mechanisms diseases. How far can move related how droplet-borne transmit. simple physical model developed used here investigate movement expelled during respiratory activities; in particular,...
Background: Few data are available about the effectiveness of nonpharmaceutical interventions for preventing influenza virus transmission. Objective: To investigate whether hand hygiene and use facemasks prevents household transmission influenza. Design: Cluster randomized, controlled trial. Randomization was computer generated; allocation concealed from treating physicians clinics implemented by study nurses at time initial visit. Participants personnel administering were not blinded to...
Abstract There are few studies describing the presence of respiratory viruses in droplets and aerosols exhaled breath infected persons, efficacy facemasks as a source control to prevent virus transmission. Here, we recruited children adults with acute illness collected aerosols, without surgical facemasks. We identified human coronaviruses, influenza rhinovirus from both aerosols. Surgical face masks reduced detection coronavirus RNA but only not for RNA. Our results provide mechanistic...
Abstract Cases of severe acute respiratory syndrome (SARS) were investigated for SARS coronavirus (SARS-CoV) through RNA tests, serologic response, and viral culture. Of 537 specimens from patients in whom was clinically diagnosed, 332 (60%) had SARS-CoV one or more clinical specimens, compared with 1 (0.3%) samples controls. 417 paired serum available, 92% an antibody response. Rates positivity increased progressively peaked at day 11 after onset illness. Although remained detectable...
Rapid diagnosis of respiratory viral infections in children resulted significantly reduced hospital stays, antibiotic use, and laboratory utilization compared with those a matched group patients from the previous year who were diagnosed by virus culture. We demonstrate that rapid is cost-effective procedure.
ABSTRACT The MICs of 17 antimicrobial agents for 181 Streptococcus pneumoniae strains were determined by the E-test. Overall, 69.1% penicillin resistant (MIC > 0.06 μg/ml). Resistance to ciprofloxacin 2 μg/ml), levofloxacin or trovafloxacin 1 μg/ml) was found in 12.1, 5.5, 2.2% strains, respectively. These high rates resistance raise concerns future.
The first outbreak of avian influenza A (H5N1) occurred among humans in Hong Kong 1997. To estimate the risk person-to-person transmission, a retrospective cohort study was conducted to compare prevalence H5N1 antibody health care workers (HCWs) exposed case-patients with nonexposed HCWs. Information on case-patient and poultry exposures blood samples for H5N1-specific testing were collected. Eight (3.7%) 217 2 (0.7%) 309 HCWs seropositive (P=.01). difference remained significant after...
The MICs of 13 antimicrobial agents including seven fluoroquinolones (ciprofloxacin, levofloxacin, sparfloxacin, grepafloxacin, gatifloxacin, moxifloxacin and clinafloxacin) for Streptococcus pneumoniae isolates obtained from all regions Hong Kong in the year 2000 were determined by Etest. Overall, 39.4% 180 susceptible to penicillin, 11.7% intermediate 48.9% resistant. overall prevalence fluoroquinolone non-susceptibility (levofloxacin MIC 4 mg/L) was 13.3% but increased 27.3% among...
BackgroundThere are sparse data on whether non-pharmaceutical interventions can reduce the spread of influenza. We implemented a study feasibility and efficacy face masks hand hygiene to influenza transmission among Hong Kong household members.Methodology/Principal FindingsWe conducted cluster randomized controlled trial households (composed at least 3 members) where an index subject presented with influenza-like-illness <48 hours duration. After was confirmed in case by QuickVue Influenza...
ABSTRACT The reverse transcription (RT)-PCR protocols of two World Health Organization (WHO) severe acute respiratory syndrome (SARS) network laboratories (WHO SARS at University Hong Kong [WHO-HKU] and the Bernhard-Nocht Institute in Hamburg, Germany [WHO-Hamburg]) were evaluated for rapid diagnosis a novel coronavirus (CoV) associated with Kong. A total 303 clinical specimens collected from 163 patients suspected to have SARS. end point both WHO-HKU WHO-Hamburg RT-PCR assays was determined...
A novel coronavirus (CoV) was recently identified as the agent for severe acute respiratory syndrome (SARS). We compared abilities of conventional and real-time reverse transcription-PCR (RT-PCR) assays to detect SARS CoV in clinical specimens.
The serological response profile of severe acute respiratory syndrome (SARS) coronavirus (CoV) infection was defined by neutralization tests and subclass-specific immunofluorescent (IF) using serial sera from 20 patients. SARS CoV total immunoglobulin (Ig) (IgG, IgA, IgM [IgGAM]) the first antibody to be detectable. There no difference in time seroconversion between patients who survived (n = 14) those died 6). Although still detectable IF with 8 11 at 7 months postinfection, geometric mean...
To determine the effectiveness of World Health Organization (WHO) multimodal strategy in promoting hand hygiene (HH) among healthcare workers (HCWs) long-term care facilities (LTCFs).Cluster-randomized controlled trial.Eighteen homes for elderly Hong Kong were randomly allocated to 2 intervention arms and a control arm. Direct observation HH practice was conducted by trained nurses. Either handrubbing with alcohol-based handrub (ABHR) or handwashing liquid soap water counted as compliant...
Background The potential for human influenza viruses to spread through fine particle aerosols remains controversial. objective of our study was determine whether could be detected in particles hospital rooms. Methods and Findings We sampled the air 2-bed patient isolation rooms four hours, placing cyclone samplers at heights 1.5m 1.0m. collected ten samples each presence least one with confirmed A virus infection, tested by reverse transcription polymerase chain reaction. recovered RNA from...