A5002878852- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
- Spine and Intervertebral Disc Pathology
- Fungal Biology and Applications
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Radiation Dose and Imaging
- Bone health and osteoporosis research
- DNA Repair Mechanisms
- Radioactive contamination and transfer
- Nerve injury and regeneration
- Bone Metabolism and Diseases
- Medicinal Plants and Bioactive Compounds
- Effects of Radiation Exposure
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- Immunotherapy and Immune Responses
- Diabetic Foot Ulcer Assessment and Management
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Tendon Structure and Treatment
- Cancer, Hypoxia, and Metabolism
Taipei Medical University
2014-2024
Fu Jen Catholic University
2016-2021
Tunghai University
2020-2021
Ton Duc Thang University
2018
Stem Cell Technology (Taiwan)
2018
Guangdong Medical College
2013-2015
Taipei Medical University Hospital
2009-2014
Mackay Memorial Hospital
2006
Harvard University
1994
The aim of this study was to assess the efficacy human mesenchymal stem cells (hMSC) for targeting microscopic tumors and suicide gene or cytokine therapy. Immunodeficient mice were transplanted s.c. with colon cancer HT-29 Inv2 CCS line, 3 4 days later, i.v. "tracer" hMSCs expressing herpes simplex virus type 1 thymidine kinase (HSV1-TK) enhanced green fluorescent protein (EGFP) reporter genes. Subsequently, these examined specificity magnitude HSV1-TK(+), EGFP(+) cell engraftment...
Abstract Human intervertebral disc (IVD) degeneration often initiated from the human nucleus pulposus (hNP) with aging leading to IVD destruction and extracellular matrix (ECM) depletion. Previously, we have successfully employed transforming growth factor‐β1 (TGF‐β1) promote chondrogenesis of mesenchymal progenitor cells (MPCs) immortalized stem cells. In this study, examine role TGF‐β1 in platelet‐rich plasma (PRP) on regeneration, including proliferation, redifferentiation, reconstitution...
// Hong-Jian Wei 1, 2 , Jac A. Nickoloff 3 Wei-Hong Chen Hen-Yu Liu Wen-Cheng Lo 4, 5 Ya-Ting Chang 1 Pan-Chyr Yang 6 Cheng-Wen Wu 7 David F. Williams 8 Juri G. Gelovani 9, 10 Win-Ping Deng Graduate Institute of Biomedical Materials and Engineering, College Oral Medicine, Taipei Medical University, 110, Taiwan Stem Cell Research Center, Department Environmental Radiological Health Sciences, Colorado State Fort Collins, CO 80523, USA 4 Neurosurgery, University Hospital, School Internal...
// Hong-Jian Wei 1,2 , Rong Zeng 3 Jui-Hua Lu 1 Wen-Fu T. Lai 4 Wei-Hong Chen 2 Hen-Yu Liu Ya-Ting Chang and Win-Ping Deng 1,2,3 Graduate Institute of Biomedical Materials Engineering, College Oral Medicine, Taipei Medical University, Taipei, Taiwan Stem Cell Research Center, Department Orthopedic Surgery, The Affiliated Hospital Guangdong College, Zhanjiang, China Clinical Correspondence to: Deng, email: Keywords : Adipose-derived stem cells, Tumor initiation, Cancer cell, Breast cancer,...
Knee osteoarthritis (OA) is one of the most prevalent disorders in elderly population. Among various therapeutic alternatives, we employed stromal vascular fraction (SVF), a heterogeneous cell population, to regenerate damaged knee cartilage. OA patients were classified on basis age, gender, body mass index (BMI), and x-ray-derived Kellgren-Lawrence (KL) grade. They treated with SVF followed-up for 24 months. Visual analogue scale (VAS) Western Ontario McMaster Universities Osteoarthritis...
Abstract Chondrogenic differentiation by mesenchymal progenitor cells (MPCs) is associated with cytokines such as transforming growth factor‐beta 1 (TGF‐β1) and dexamethasone. Extracellular matrix (ECM) also regulates the MPCs. To define whether ECM plays a functional role in regulation of chondrogenic MPCs, an vitro model was used. That exposed to dexamethasone, recombinant human TGF‐β1( rh TGF‐β1) collagens. The results showed that MPCs incorporated dexamethasone TGF‐β1 increased...
The PI3K/Akt/mTOR pathway is considered to be an attractive target for the development of novel anticancer molecules. This paper reports first time that a small molecule, antrocin (MW = 234), from Antrodia camphorata was potent antagonist in various cancer types, being highest metastatic breast MDA-MB-231 cells (MMCs) with IC50 value 0.6 μM. Antrocin superior antiproliferator MMCs as compared doxorubicin and cisplatin, prevents colony formation, nontoxic nontumorgenic MCF10A HS-68 cells....
Low-back pain caused by intervertebral disc degeneration could be recovered the regeneration of nucleus pulposus (NP). This study aimed to establish a chondrogenic recovery model with promising human NP (hNP) cell line, an immortalized hNP (ihNP), which screening platform identify regenerative drugs. The ihNP cells were created from primary transfected retroviral vector-driven HPV16 E6/E7. Growth properties and characteristics evaluated comparing parental cells. Successful immortalization...
Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes DN. Hence, this study aimed further investigate the renal injury-reducing effect CmNo1, a novel combination powders fruiting bodies mycelia Cordyceps militaris. After being administered with streptozotocin-nicotinamide high-fat-diet, mouse model displayed elevated dysfunction markers...
Recent years have witnessed an increased prevalence of knee osteoarthritis (KOA) among diabetes mellitus (DM) patients-conditions which might share common risk factors such as obesity and advanced aging. Therefore, we conducted dry-to-wet lab research approaches to assess the correlation type 1 DM (T1DM) 2 (T2DM) with KOA all age genders Taiwanese population. The strength association (odds ratio: OR) was analyzed using a phenome-wide study portal. Populations 37,353 T1DM 1,218,254 T2DM were...
The conventional approach for radiation protection is based on the ICRP's linear, no threshold (LNT) model of carcinogenesis, which implies that ionizing always harmful, matter how small dose. But a different can be derived from observed health effects serendipitous contamination 1700 apartments in Taiwan with cobalt-60 (T 1/2 = 5.3 y). This experience indicates chronic exposure whole body to low-dose-rate radiation, even accumulated high annual dose, may beneficial human health....
Osteoarthritis (OA) poses a major clinical challenges owing to limited regenerative ability of diseased or traumatized chondrocytes in articular cartilage.Previous studies have determined the individual therapeutic efficacies hyaluronic acid (HA) and platelet-rich plasma (PRP) on OA; however, underlying mechanism is still lacking.Therefore, we investigated mechanistic approach HA+PRP therapy chondrocyte apoptosis IL-1β+TNF-α (I+T) treated vitro OA model, addition vivo anterior cruciate...
Background: Recent studies have shown evidence that higher adiposity in the infrapatellar fat pad (IFP) induces inflammatory phenotypes knee joint and thereby contributes to development progression of osteoarthritis (OA). In particular, IFP adipocyte–derived cytokines participate pathological events. Our previous research has already addressed therapeutic efficacy hyaluronic acid platelet-rich plasma (HA+PRP), including promotion cartilage regeneration inhibition inflammation. The current...