The antioxidant and antiinflammatory effects of flavonols have been suggested to be structure-related. Results revealed that selected flavonols, including fisetin (F), kaempferol (K), morin (MO), myricetin (MY), quercetin (Q), exhibited distinctive free radical scavenging properties against different kinds radicals. H donation (DPPH bleaching) potential was Q > F ≈ MY MO K, indicating the presence a 3',4'-catechol moiety in B ring correlated with high activity. 4'-OH important for reducing...

Luteolin (3′,4′,5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to possess antioxidant, anti-inflammatory, and anticancer activities. In this work, we assessed whether luteolin neurotrophic activity, namely, the ability induce neurite outgrowth attenuate serum withdrawal-induced cytotoxicity in PC12 cells. Our results show that significantly induced along with increased expression of differentiation marker, growth-associated protein-43 (GAP-43), cells dose-dependently....

Curcuminoids, the predominant polyphenolic compounds in rhizome of Curcuma longa Linn., consist curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). They exhibit multiple desirable characteristics for a neuroprotective agent including antioxidant, anti-inflammatory, antiamyloid activities. In this work, we report first investigation neurotrophic action mechanism curcuminoids PC12 cells, which respond to nerve growth factor (NGF) therefore serve as model system primary neuronal...

Curcumin has been demonstrated as having numerous desirable characteristics, such antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect molecular mechanism of curcumin.We found that curcumin enhanced LDL receptor (LDLR) level on cell surface, well LDLR activity; however, transcription mRNA stability were not affected. Furthermore, we proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was downregulated at transcriptional by curcumin,...

The neurotoxin 6-hydroxydopamine (6-OHDA), which causes transcriptional changes associated with oxidative and proteotoxic stress, has been widely used to generate an experimental model of Parkinson's disease. food-derived compound luteolin multi-target actions including antioxidant, anti-inflammatory neurotrophic activities. aim this study is investigate how affects 6-OHDA-mediated stress response pathways. results showed that when PC12 cells were pre-treated (20 µM) 30 min prior 6-OHDA (100...

Luteolin and apigenin are dietary flavones exhibit a broad spectrum of biological activities including antioxidant, anti-inflammatory, anti-cancer neuroprotective effects. The lipid peroxidation product 4-hydroxy-2-nonenal (4-HNE) has been implicated as causative agent in the development neurodegenerative disorders. This study investigates cytoprotective effects luteolin against 4-HNE-mediated cytotoxicity neuronal-like catecholaminergic PC12 cells. Both restored cell viability repressed...

It was demonstrated that isoflavones can cross the blood–brain barrier, making them desirable candidate agents for prevention of neurological symptoms. 8-Hydroxydaidzein (8-OHD, 4′,7,8-trihydoxyisoflavone) is an isoflavone found only in fermented soy food. Current results showed 8-OHD inhibited LPS-stimulated production nitric oxide (NO) and proinflammatory cytokines, such as tumor necrosis factor (TNF)-α interleukin (IL)-6, by inhibiting gene expression BV2 microglial cells. Moreover,...

Angiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), with potential to manage lipid...

Atherosclerosis is a chronic inflammatory disease of the arterial wall. Kaempferol and rhamnocitrin (kaempferol 7-O-methyl ether) are two anti-inflammatory flavonoids commonly found in plants. The aim this study to investigate function kaempferol on prevention atherosclerosis. Chemical analyses demonstrated that were scavengers DPPH (1,1-diphenyl-2-picrylhydrazyl) with IC50 26.10 ± 1.33 28.38 3.07 µM, respectively. Copper-induced low-density lipoprotein (LDL) oxidation was inhibited by...

Luteolin (3′,4′,5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity promote neuronal survival and neurite outgrowth. In this study, we report for the first time luteolin induces persistent expression of microRNA-132 (miR-132) in PC12 cells. The correlation between miR-132 knockdown decrease luteolin-mediated outgrowth may indicate mechanistic link by which functions as mediator neuritogenesis....

Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonol and exhibits antioxidant, anti-inflammatory, neuroprotective activities. However, high concentration of fisetin reported to produce reactive oxygen species (ROS), induce endoplasmic reticulum (ER) stress cause cytotoxicity in cancer cells. The aim this study investigate the cytoprotective effects low against tunicamycin (Tm)-mediated neuronal-like catecholaminergic PC12 Cell viability was assayed by MTT...

Sinomenine is an alkaloid derived from Sinomenium acutum. Recent studies have found that sinomenine can inhibit various cancers by inhibiting the proliferation, migration and invasion of tumors inducing apoptosis. This study aims to investigate effect mechanism on human lung adenocarcinoma cells in vitro. The results demonstrate viabilities A549 H1299 were inhibited a dose-dependent manner. When treated with sub-toxic doses sinomenine, cell are markedly suppressed. decreases mRNA level...

Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature and inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, present abundantly in citrus peels has been reported possess anti-cancer activity. In this study, we investigated anti-leukemic effects NOB on its underlying mechanisms human chronic myeloid leukemia (CML) K562 cells. (100 μM) treatment 24 48 h significantly decreased...

In this study, hydrogen peroxide ( H 2 O )-mediated Caco-2 cytotoxicity was employed to investigate the potential antioxidant activity of methanol extract from lotus leaf (Nelumbo nucifera Gertn.). A dose-dependent protective effect against reactive oxygen species (ROS)-induced observed when cells were treated with 10 mM in combination (0.1–0.3 mg/ml). However, no significant found co-treating and α-tocopherol. vitro assay revealed that exhibited scavenging activities on free radicals...

5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly peels of sweet orange. In this research, we report first investigation neurotrophic effects and mechanism 5-OH-HxMF PC12 pheochromocytoma cells. We that can effectively induce neurite outgrowth accompanied with expression neuronal differentiation marker protein growth-associated protein-43(GAP-43). caused enhancement cyclic AMP response element...