A5000312975- Advancements in Semiconductor Devices and Circuit Design
- Silicon Nanostructures and Photoluminescence
- Semiconductor materials and devices
- Semiconductor Quantum Structures and Devices
- Quantum and electron transport phenomena
- Magnetic properties of thin films
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Semiconductor materials and interfaces
- Advanced Memory and Neural Computing
- Thin-Film Transistor Technologies
- Magnetic Properties and Applications
- Molecular Junctions and Nanostructures
- Photonic and Optical Devices
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Circular RNAs in diseases
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
- Silicon and Solar Cell Technologies
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds in Plants
- Prenatal Screening and Diagnostics
- Nanowire Synthesis and Applications
- ZnO doping and properties
Gannan Normal University
2025
Tzu Chi University
2011-2024
Guangzhou Quality Supervision, Inspection and Research Institute
2022-2024
Chia-Yi Christian Hospital
2019-2024
Pearl River Hydraulic Research Institute
2024
National Taipei University of Nursing and Health Science
2019-2024
Duke University
2023
South China University of Technology
2022
Changchun University of Chinese Medicine
2022
Hualien Tzu Chi Medical Center
2014-2022
Curcuminoids, the predominant polyphenolic compounds in rhizome of Curcuma longa Linn., consist curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). They exhibit multiple desirable characteristics for a neuroprotective agent including antioxidant, anti-inflammatory, antiamyloid activities. In this work, we report first investigation neurotrophic action mechanism curcuminoids PC12 cells, which respond to nerve growth factor (NGF) therefore serve as model system primary neuronal...
Curcumin has been demonstrated as having numerous desirable characteristics, such antioxidant, anti-inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect molecular mechanism of curcumin.We found that curcumin enhanced LDL receptor (LDLR) level on cell surface, well LDLR activity; however, transcription mRNA stability were not affected. Furthermore, we proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was downregulated at transcriptional by curcumin,...
Angiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), with potential to manage lipid...
Luteolin (3′,4′,5,7-tetrahydroxyflavone), a food-derived flavonoid, has been reported to exert neurotrophic properties that are associated with its capacity promote neuronal survival and neurite outgrowth. In this study, we report for the first time luteolin induces persistent expression of microRNA-132 (miR-132) in PC12 cells. The correlation between miR-132 knockdown decrease luteolin-mediated outgrowth may indicate mechanistic link by which functions as mediator neuritogenesis....
Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature and inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, present abundantly in citrus peels has been reported possess anti-cancer activity. In this study, we investigated anti-leukemic effects NOB on its underlying mechanisms human chronic myeloid leukemia (CML) K562 cells. (100 μM) treatment 24 48 h significantly decreased...
Abstract Cinnamon bark (Rou Gui in Chinese), cinnamon twig (Gui Zhi) and shaved Sin) have been widely used as spices traditional Chinese medicine since ancient times. On‐going issues related to quality authenticity necessitate the development of analytical methods capable providing an objective evaluation samples. In this study, chemical fingerprints bark, twigs were established using liquid chromatography quadruple time‐of‐flight mass spectrometry conjunction with principal component...
Tanshinone IIA, one of the most pharmacologically bioactive phytochemicals isolated from Salvia miltiorrhiza Bunge, possesses several biological activities such as anti-inflammation, anti-cancer, neuroprotection and hypolipidemic activities. In this study, we aim to investigate hypocholesterolemic effect tanshinone IIA in hepatic cells. We demonstrated that significantly increased amount low-density lipoprotein receptor (LDLR) LDL uptake activity HepG2 cells at post-transcriptional...
Fisetin (3,7,3',4'-tetrahydroxyflavone), a flavonol compound of flavonoids, exhibits broad spectrum biological activities including anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective effects. The aim this study is to investigate the cytoprotective effect fisetin underlying molecular mechanism against hypoxia-induced cell death in PC12 cells. results showed that significantly restored viability cells under both cobalt chloride (CoCl₂)- low oxygen-induced hypoxic conditions....
Gestational diabetes mellitus (GDM) places both the mother and offspring at high risk of complications. Increasing evidence suggests that gut microbiota plays a role in pathogenesis GDM. However, it is still unclear whether related to blood biochemical traits, particularly glucagon-like peptide-1 (GLP-1), GDM patients.To explore correlation between GLP-1, patients.The V4 region 16S ribosomal ribonucleic acid (rRNA) gene was sequenced based on fecal samples 35 pregnant women with compared 25...
High endothelial venules (HEV) have been recognized to play a role in metastasis by its changes seen the cancer microenvironment of lymph nodes (LN) and solid cancers. Squamous cell carcinoma (SCC) tongue is prevalent tumor head neck region with high propensity for LN metastasis. The extent most reliable adverse prognostic factor. Primary tumors can induce vasculature reorganization within sentinel before arrival cells HEV represents these remodelled vessels. This study aims evaluate induced...
Polymethoxyflavones (PMFs) exhibit a broad spectrum of biological properties, including anticancer, antiatherogenic, and neuroprotective effects. The aim this study is to investigate the neurotrophic effects 5-demethylnobiletin, hydroxylated PMF found in citrus plants, gardenin A, synthetic analogue, on neurite outgrowth neuronal differentiation PC12 cells. results showed that 5-demethylnobiletin A (10-20 μM) potently induce cells, accompanied by expression synapse formation marker proteins,...
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature steatosis nonalcoholic fatty liver disease (NAFLD) or metabolic-associated (MAFLD). Dysregulation lipogenesis contributes to plays an essential role in pathological progress MAFLD. Tanshinone IIA a bioactive phytochemical isolated from Salvia miltiorrhiza Bunge exhibits anti-inflammatory, antiatherosclerotic antihyperlipidemic effects. In this study, we aimed investigate lipid-lowering effects...
Pinostrobin, a flavonoid phytochemical found in variety of plants, has been demonstrated to possess numerous bioactivities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. The aim this study was investigate the hypocholesterolemic effect pinostrobin on regulation gene expression PCSK9 its underlying mechanisms hepatic cells. We that (20 40 μM) significantly inhibited promoter activity from 1.00 ± 0.16 (fold) 0.85 0.06 0.54 0.05, respectively, well...
Significance Our study provides significant advances in the understanding of circulating exosomal microRNA (miRNA) animals. Circulating miRNAs mediate communication among tissues and organs. In glia, mature miR-274 is produced secreted to hemolymph target recipient cells, neurons, tracheal cells. We also identified gene sty whose expression down-regulated by target/recipient Downregulation Sty leads upregulation MAPK signaling, thereby promoting growth synaptic boutons branches. Thus,...
The excessive accumulation of TG-rich lipoproteins (TGRLs) in plasma is associated with dyslipidemia and atherosclerotic cardiovascular diseases (ASCVDs). Tangeretin a bioactive pentamethoxyflavone mainly found citrus peels, it has been reported to protect against hyperlipidemia, diabetes, obesity. aim this study was investigate the lipid-modulating effects underlying mechanisms tangeretin action hepatic cells. Transcriptome bioinformatics analyses Gene Ontology (GO) database showed that...
Acute myeloid leukemia (AML) is characterized by the dysregulation of hematopoietic cell proliferation, resulting in accumulation immature cells bone marrow. 5-Demethylnobiletin (5-demethyl NOB), a citrus 5-hydroxylated polymethoxyflavone, has been reported to exhibit various bioactivities, such as antioxidant, anti-inflammatory and anticancer properties. In this study, we investigated antileukemic effects 5-demethyl NOB its underlying molecular mechanisms human AML cells. We found that...
The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the overproduction of corticosterone, leading neurotoxicity in brain. Fisetin a flavonoid commonly found fruits and vegetables. It has been suggested possess various biological activities, including antioxidant, anti-inflammatory, neuroprotective effects. This study aims explore potential properties fisetin against corticosterone-induced cell death its underlying molecular mechanism PC12 cells. Our results...