A5062280000- Tryptophan and brain disorders
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- High Altitude and Hypoxia
- Neuroinflammation and Neurodegeneration Mechanisms
- Electroconvulsive Therapy Studies
- Immune Response and Inflammation
- Stress Responses and Cortisol
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Pain Management and Treatment
- Pharmacological Effects and Toxicity Studies
- Circadian rhythm and melatonin
- Spinal Cord Injury Research
- Herbal Medicine Research Studies
- Nitric Oxide and Endothelin Effects
- Berberine and alkaloids research
- Amino Acid Enzymes and Metabolism
- Bipolar Disorder and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Adrenal Hormones and Disorders
China Medical University
2013-2024
National Taiwan University of Science and Technology
2022
China Medical University Hospital
2012-2013
Kaohsiung Veterans General Hospital
2013
National Taiwan University
2004-2005
Abstract The AMPK cascade is a sensor of cellular energy change, which monitors the AMP/ATP ratio to regulate metabolism by restoring ATP levels, but its regulation neuroinflammation mechanism remains unclear. Berberine, one major constituents Chinese herb Rhizoma coptidis, has been shown improve several metabolic disorders, such as obesity and type II diabetes. However, effect berberine on neuroinflammatory responses in microglia are poorly understood. This study shows that represses...
Article AbstractBackground: Repetitive transcranial magnetic stimulation (rTMS) has been developed as a novel tool for improving depression by delivering to the brain. However, apparent effects of rTMS on have varied in different studies. The aims this study were determine whether left dorsolateral prefrontal cortex can alleviate medication-resistant Chinese patients and investigate what demographic variables or clinical features may predict better response. Method: We designed 2-week...
Several natural products have been demonstrated to be effective in the treatment of depressive disorders. Echinacoside, a naturally occurring phenol extracted from Cistanche tubulosa, Echinacea angustifolia, and spp, has wide range physiological effects, such as antioxidation, neuroprotection, anti-inflammatory, immunoregulation, which are closely related depression. In addition, echinacoside can activate protein kinase B (Akt), extracellular signal-regulated (ERK), brain-derived...
Oxidative stress and large amounts of nitric oxide (NO) have been implicated in the pathophysiology neuronal injury neurodegenerative disease. Recent studies shown that (-)-epigallocatechin gallate (EGCG), one green tea polyphenols, has potent antioxidant effects against free radical-mediated lipid peroxidation ischemia-induced damage. The purpose this study was to examine whether EGCG would attenuate expression NADPH-d/nNOS motor neurons lower brainstem following peripheral nerve crush....
Sarcosine, an endogenous amino acid, is a competitive inhibitor of the type I glycine transporter and N-methyl-d-aspartate receptor (NMDAR) coagonist. Recently, we found that sarcosine, NMDAR enhancer, can improve depression-related behaviors in rodents humans. This result differs from previous studies, which have reported antidepressant effects antagonists. The mechanisms underlying therapeutic response sarcosine remain unknown. study examines role mammalian target rapamycin (mTOR)...
Vanillic acid, an oxidized form of vanilla, is a flavoring agent with creamy odor. Several studies have reported the neuroprotective effects vanillic which are predominantly associated anti-inflammatory and antioxidative properties. The properties may result from Akt or ERK signaling activation. activation mammalian target rapamycin (mTOR), key downstream signaling, crucial therapeutic for treating depression. However, antidepressant acid remain unknown. present study applied forced swim...
d-Serine is an amino acid and can work as agonist at the glycine sites of N-methyl-d-aspartate receptor (NMDAR). Interestingly, both types glutamatergic modulators, NMDAR enhancers blockers, improve depression through common targets, namely alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionaic receptors (AMPARs) mammalian target rapamycin (mTOR). To elucidate cellular signaling pathway underlying this counterintuitive observation, we activated NMDARs in rats by using d-serine. Saline,...
It is well documented that the nitric oxide (NO) might be directly involved in brain response to hypobaric hypoxia, and could contribute memory deficiencies. Recent studies have shown melatonin attenuate hypoxia or ischemia-induced nerve injuries by decreasing production of free radicals. The present study, using immunohistochemical immunoblot methods, aimed explore whether treatment may affect expression system protein nitration, provide neuroprotection rat hippocampus injured hypoxia....
Abstract: Lipopolysaccharide (LPS), the major proinflammatory component of gram‐negative bacteria, is well known to induce sepsis and microglial activation in CNS. On contrary, effect products from gram‐positive bacteria especially areas devoid blood–brain barrier remains be explored. In present study, a panel antibodies, namely, OX‐6, OX‐42 ED‐1 was used study response microglia/macrophages pineal gland rats given an intravenous LPS or lipoteichoic acid (LTA). These antibodies recognize MHC...
Perturbation of cochlear microcirculation, that is, ischemia is a major cause hearing impairment. Earlier studies examined the short-term (≤7 days) effect ischemia. This study characterized long-term (4 weeks) functional and morphological changes in adult guinea pig cochleae subject to transient by clamping labyrinthine artery for 0.25–3 h. Notably, over 1 h caused an increase auditory brainstem response thresholds loss high-frequency hearing, basal-turn hair cells, spiral ganglions....
Puerarin is a traditional Chinese medicine with beneficial effects of reduced depression-like behaviors in mice stress. Previous studies also show that puerarin can produce neuroprotective effect via activating the Akt or increased brain-derived neurotrophic factor (BDNF) expression. Interestingly, BDNF and downstream target, mammalian target rapamycin (mTOR) mediate fast-acting antidepressant properties ketamine. Until now, involvement mTOR signaling pathway on puerarin-induced remains...