A5000183342- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- FOXO transcription factor regulation
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Hops Chemistry and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Garlic and Onion Studies
- Lipid metabolism and biosynthesis
- Bioactive Compounds in Plants
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Horticultural and Viticultural Research
- Immune Cell Function and Interaction
- Phytochemical compounds biological activities
- Medicinal Plants and Bioactive Compounds
- Atherosclerosis and Cardiovascular Diseases
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Microbial Metabolism and Applications
- Cancer-related molecular mechanisms research
Tzu Chi University
2018-2024
Angiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), 8-prenylnaringenin (8-PN), with potential to manage lipid...
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature steatosis nonalcoholic fatty liver disease (NAFLD) or metabolic-associated (MAFLD). Dysregulation lipogenesis contributes to plays an essential role in pathological progress MAFLD. Tanshinone IIA a bioactive phytochemical isolated from Salvia miltiorrhiza Bunge exhibits anti-inflammatory, antiatherosclerotic antihyperlipidemic effects. In this study, we aimed investigate lipid-lowering effects...
The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the overproduction of corticosterone, leading neurotoxicity in brain. Fisetin a flavonoid commonly found fruits and vegetables. It has been suggested possess various biological activities, including antioxidant, anti-inflammatory, neuroprotective effects. This study aims explore potential properties fisetin against corticosterone-induced cell death its underlying molecular mechanism PC12 cells. Our results...
Pinostrobin, a flavonoid phytochemical found in variety of plants, has been demonstrated to possess numerous bioactivities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. The aim this study was investigate the hypocholesterolemic effect pinostrobin on regulation gene expression PCSK9 its underlying mechanisms hepatic cells. We that (20 40 μM) significantly inhibited promoter activity from 1.00 ± 0.16 (fold) 0.85 0.06 0.54 0.05, respectively, well...
The excessive accumulation of TG-rich lipoproteins (TGRLs) in plasma is associated with dyslipidemia and atherosclerotic cardiovascular diseases (ASCVDs). Tangeretin a bioactive pentamethoxyflavone mainly found citrus peels, it has been reported to protect against hyperlipidemia, diabetes, obesity. aim this study was investigate the lipid-modulating effects underlying mechanisms tangeretin action hepatic cells. Transcriptome bioinformatics analyses Gene Ontology (GO) database showed that...
Nobiletin, a dietary citrus flavonoid, has been reported to possess several biological activities such as antioxidant, anti-inflammatory, and anticancer properties. The aim of this study was investigate the antileukemic effects nobiletin its underlying mechanisms on human acute myeloid leukemia (AML) cells. We demonstrated that (0-100 μM) significantly reduced cell viability from 100.0 ± 9.6% 31.1 2.8% in AML THP-1 line. Nobiletin arrested cycle progression G1 phase induced differentiation...
Pigeon pea (Cajanus cajan (L.) Millsp.) is a legume crop consumed as an indigenous vegetable in the human diet and traditional medicinal plant with therapeutic properties. The current study highlights cholesterol-modulating effect underlying mechanisms of methanol extract Cajanus L. leaves (MECC) HepG2 cells. We found that MECC increased LDLR expression, cell-surface levels LDL uptake activity further demonstrated suppressed proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA protein...
Nobiletin, a dietary citrus flavonoid, exerts biological activities against hyperlipidemia, obesity, and atherosclerotic cardiovascular diseases (ASCVDs). The aim of this study was to explore the lipid-lowering effects nobiletin underlying molecular mechanisms in vitro hepatic cells vivo zebrafish models. Transcriptome gene ontology (GO) analyses differentially expressed genes (DEGs) by set enrichment analysis (GSEA) showed that twenty-eight core DEGs associated with "GO BP regulation lipid...
Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and atherosclerosis. In this study, we focused on the hypocholesterolemic effect of Xan cholesterol uptake underlying molecular mechanisms human intestinal Caco-2 cells. The microarray data showed that Niemann–Pick C1-like 1 (NPC1L1), an essential transporter for dietary absorption, was significantly downregulated Xan-treated We (10 20 μM)...