A5100648268- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Sleep and Wakefulness Research
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Sleep and related disorders
- Zebrafish Biomedical Research Applications
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Protein Degradation and Inhibitors
- Molecular Biology Techniques and Applications
Huazhong University of Science and Technology
2025
National Taiwan University
2015-2024
Ningbo University
2024
Fujian Medical University
2024
Union Hospital
2024
Shanghai Changzheng Hospital
2016-2024
First Affiliated Hospital of Fujian Medical University
2024
Sun Yat-sen Memorial Hospital
2019-2024
Sun Yat-sen University
2019-2024
National Taiwan University Hospital
2014-2023
A new reproducibility index is developed and studied. This the correlation between two readings that fall on 45 degree line through origin. It simple to use possesses desirable properties. The statistical properties of this estimate can be satisfactorily evaluated using an inverse hyperbolic tangent transformation. Monte Carlo experiment with 5,000 runs was performed confirm estimate's validity. An application actual data given.
TDP-43 has been found in inclusion bodies of multiple neurological disorders, including amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. Mutations the encoding gene, TARDBP, have subsequently reported sporadic familial ALS patients. In order to investigate pathogenic nature these mutants, effects three consistently TARDBP mutations (A315T, G348C A382T) were tested cell lines, primary cultured motor neurons living zebrafish embryos. Each...
Deposition of insoluble protein aggregates is a hallmark neurodegenerative diseases. The universal presence β-amyloid and tau in Alzheimer’s disease (AD) has facilitated advancement the amyloid cascade hypotheses that have dominated AD pathogenesis research therapeutic development. However, underlying etiology remains to be fully elucidated. Here we report comprehensive study human brain-insoluble proteome by mass spectrometry. We identify 4,216 proteins, among which 36 proteins accumulate...
Reversal of CD8 T-cell exhaustion was considered a major antitumor mechanism anti-programmed cell death-1 (PD-1)/ death ligand-1 (PD-L1)-based immune checkpoint inhibitor (ICI) therapy.The aim this study to identify markers that is best associated with ICI treatment efficacy for advanced hepatocellular carcinoma (HCC).Immune composition archival tumor samples analyzed by transcriptomic analysis and multiplex immunofluorescence staining.HCC patients objective response after...
Abstract Purpose: The transcription factor CCAAT/enhancer binding protein α, encoded by the CEBPA, is crucial for differentiation of immature granulocytes. Mutation CEBPA may play an important role in leukemogenesis and prognosis. We sought to characterize mutation acute myeloid leukemia (AML) clarify if there a distinct immunophenotype leukemic cells with mutation. Experiment Design: One hundred four patients de novo AML were evaluated cells. Results: Twenty-two mutations identified 16...
Abstract Nucleophosmin (NPM) mutations have been found in a significant proportion of adults with de novo acute myeloid leukemia (AML), especially those normal karyotype. These results provide basis for studies the pathogenesis this specific subgroup AML. In study, NPM were analyzed 173 Chinese patients AML, including and children. We that present 19.1% overall population 40.3% Adults had significantly higher incidence than children [32 126 (25.4%) versus 1 47 (2.1%), P < 0.001]....
Abstract The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this during clinical course remains unclear. In study, mutations were identified 7% 500 de novo AML and 58.8% CK. closely associated older age, lower white blood cell (WBC) platelet counts, FAB M6 subtype, unfavorable-risk cytogenetics CK, negatively NPM1 mutation, FLT3/ ITD DNMT3A mutation. Multivariate analysis demonstrated that was an independent...
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in community with chronic back pain.PRSs were developed validated European East Asian ethnicity, using data genome-wide association studies 15 585 AS 20 452 controls. The discriminatory values PRSs these populations compared other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 sacroiliac...
The European LeukemiaNet (ELN) recently proposed a revised recommendation for the diagnosis and management of acute myeloid leukemia (AML) in adults, recognized as ELN-2022. However, validation large real-world cohort remains lacking. In this study, we aimed to validate prognostic relevance ELN-2022 809 de novo, non-M3, younger (ages 18-65 years) AML patients receiving standard chemotherapy. risk categories 106 (13.1%) were reclassified from that determined using ELN-2017 effectively helped...
Summary Mutations of Runt‐related transcription factor 1 ( RUNX1 ) have been detected in patients with myelodysplastic syndrome (MDS). However, the prognostic implication mutations primary MDS is limited. The stage disease at which are acquired and whether they persist during course also remain unclear. We analysed exons 3–8 132 correlated results clinical features. Serial studies were performed follow‐up period. Sixteen (12%) had time diagnosis. All that diagnosis remained unchanged course....
Curcumin (diferuloylmethane), widely used as a spice and coloring agent in food, possesses potent antioxidant, anti-inflammatory anticarcinogenic properties. Recently, curcumin was further demonstrated to have an antimetastatic effect mice. In this study, we attempted clarify the possible mechanisms of latter curcumin. A highly invasive SK-Hep-1 cell line human hepatocellular carcinoma (HCC) selected for study. An vitro assay, without or with Matrigel matrix, quantitate cellular migration...
// Hsin-An Hou 1 , Chieh-Yu Liu 2 Yuan-Yeh Kuo 3 Wen-Chien Chou 1,4 Cheng-Hong Tsai 1,5 Chien-Chin Lin Liang-In 6 Mei-Hsuan Tseng Ying-Chieh Chiang Ming-Chih 7 Chia-Wen Jih-Luh Tang Ming Yao Chi-Cheng Li Shang-Yi Huang Bor-Sheng Ko Szu-Chun Hsu 4 Chien-Yuan Chen Chien-Ting Shang-Ju Wu Woei Tsay and Hwei-Fang Tien Division of Hematology, Department Internal Medicine, National Taiwan University Hospital, Taipei, Biostatistics Consulting Laboratory, Nursing, Taipei College Graduate Institute...
Abstract Gene mutations have not yet been included in the 2016 WHO classification and revised International Prognostic Scoring System (IPSS-R), which are now widely utilized to discriminate myelodysplastic syndrome (MDS) patients regarding risk of leukemia evolution overall survival (OS). In this study, we aimed investigate whether integration gene with other factors could further improve stratification MDS patients. Mutational analyses 25 genes relevant myeloid malignancies 426 primary...
The mosquito-borne Chikungunya virus (CHIKV) is a profound global threat due to its high rate of contagion and the lack vaccine or effective treatment. Suramin symmetric polyanionic naphthylurea that widely used in clinical treatment parasite infections. Numerous studies have reported broad antiviral activities suramin; however, inhibition effects against CHIKV not yet been demonstrated. aim this study was thus investigate effect suramin on infection elucidate molecular mechanism underlying...
Next-generation sequencing (NGS) has been applied to measurable/minimal residual disease (MRD) monitoring after induction chemotherapy in patients with acute myeloid leukemia (AML), but the optimal time point for test remains unclear. In this study, we aimed investigate clinical significance of NGS MRD at 2 different points. We performed targeted 54 genes bone marrow cells serially obtained diagnosis, first complete remission (first point), and consolidation (second point) from 335 de novo...
Narcolepsy is a sleep disorder that has been shown to be tightly associated with HLA DR15 (DR2). In this study, 58 non-DR15 patients narcolepsy-cataplexy were typed at the DRB1, DQA1 and DQB1 loci. Subjects included both sporadic cases narcoleptic probands from multiplex families. Additional markers studied in class II region promoters of genes, two CA repeat polymorphisms (DQCAR DQCARII) located between three (G51152, T16CAR G411624R) DQB3 DQB2 locus. Twenty-one (36%) these DQA1*0102...