A5056940060- Spondyloarthritis Studies and Treatments
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Systemic Sclerosis and Related Diseases
- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- MicroRNA in disease regulation
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Dermatological and Skeletal Disorders
- Diabetes and associated disorders
- Cardiac Fibrosis and Remodeling
Tehran University of Medical Sciences
2016-2025
University of Tehran
2025
Ahvaz Jundishapur University of Medical Sciences
2024
Center for Rheumatology
2024
Rheumatology Research Center
2024
Shariati Hospital
2020-2024
Golestan University
2023
Arak University of Medical Sciences
2022
Bu-Ali Sina University
2022
Iran University of Medical Sciences
2014-2018
There are no determined treatment agents for severe COVID-19. It is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of respiratory system in COVID-19 patients.We conducted a single-blind, randomised controlled clinical trial involving hospitalised patients with confirmed at early pulmonary phase illness Iran. The were randomly allocated 1:1 ratio by block randomisation method to receive standard care methylprednisolone pulse (intravenous...
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in community with chronic back pain.PRSs were developed validated European East Asian ethnicity, using data genome-wide association studies 15 585 AS 20 452 controls. The discriminatory values PRSs these populations compared other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 sacroiliac...
Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis common in Turkish and Iranian populations. Familial Mediterranean Fever (FMF) an autosomal recessive autoinflammatory disease most people of origin. MEFV, FMF-associated gene, also candidate gene for AS. We aimed to identify AS susceptibility loci examine the association between MEFV cohorts. performed genome-wide studies 1001 patients 1011 controls, 479 830 controls. Serum IL-1β, IL-17 IL-23 cytokine levels were...
Abstract The nuclear factor-κB (NF-κB) signaling pathway regulates multiple processes in innate and adaptive immune cells. This is involved inflammation through the regulation of cytokines, chemokines, adhesion molecules expression. NF-κB transcription factor also participates survival, proliferation, differentiation Therefore, deregulated activation contributes to pathogenesis inflammatory diseases. Rheumatoid arthritis (RA) classified as a heterogeneous complex autoimmune disease. Although...
Background: Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory of the intestinal tract. Tumor necrosis factor-alpha (TNF-α) signaling plays major role in pathogenesis IBD and commonly targeted for therapeutic purposes. Results on contribution TNF-α -308 -238 single nucleotide polymorphisms (SNP) to susceptibility have been contradictory differ- ent populations. Methods: Allele frequency genotype status SNPs were investigated 75 un- related patients with [40...
Summary Recurrent aphthous stomatitis ( RAS ) is a common painful, ulcerative oral inflammatory disorder with unknown aetiology. Immune system and aberrant cytokine cascade deemed to be critical in outbreaks of ulcers. Interleukin‐1 IL ‐1) ‐6 are the most potent pro‐inflammatory cytokines. Single nucleotide polymorphisms SNP s) ‐1 genes can affect secretion these The aim this study was investigate association between Iranian subjects minor . Genomic DNA obtained from 64 patients α C −889 T,...
Recurrent aphthous stomatitis (RAS) is a common oral inflammatory disease with unknown etiology in which the immune system seems to have role tolerance. Interleukin (IL)-10 cytokine synthesis inhibitory factor. Single nucleotide polymorphisms (SNPs) of IL10 gene could alter this production. The aim study was investigate frequencies alleles and genotypes group individuals RAS. Genomic DNA 60 Iranian patients RAS were typed for (C/A -1082, C/T -819, C/A -592), using PCR-SSP method. Frequency...
Tumor necrosis factor-alpha (TNF-α) could be considered as potential biomarkers in atopic dermatitis (AD), while its level influenced by cytokine single gene polymorphisms (SNP). This study was performed 89 pediatric patients with AD and 137 controls to assess of the TNF-α at positions -308 -238, using polymerase chain reaction sequence-specific primers method. The highest positive allelic association that made susceptible seen for -238/G (p<0.001) -308/G (p = 0.003). GG genotypes -238 -308,...
Changes in cytokine expression have been frequently found patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within genes.The present study was designed investigate possible association between Interleukin IL-4 and IL-10 genes susceptibility clinical features of IBD.The population composed 140 healthy controls 75 IBD (40 Crohn's (CD) 35 ulcerative colitis (UC)). Genotyping performed using polymerase chain...
Abstract Background Through investigating genetic variations, it has been demonstrated that single nucleotide polymorphisms (SNPs) in the IL-23 receptor ( IL23R ) gene have a critical role pathophysiology of ankylosing spondylitis (AS). Here, we investigated whether variant (rs1884444) is associated with AS Iranian population. Methods and material In this research, analyzed rs1884444 group 425 patients 400 matched controls. For DNA extraction, phenol/chloroform technique was utilized....