A5078377649- Spondyloarthritis Studies and Treatments
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Inflammatory Bowel Disease
- Rheumatoid Arthritis Research and Therapies
- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
- Ocular Diseases and Behçet’s Syndrome
- Garlic and Onion Studies
- Iron Metabolism and Disorders
- Genetic Associations and Epidemiology
- IL-33, ST2, and ILC Pathways
- Pomegranate: compositions and health benefits
- Animal Nutrition and Physiology
- Hops Chemistry and Applications
- Autoimmune and Inflammatory Disorders Research
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Hemoglobinopathies and Related Disorders
- Eosinophilic Disorders and Syndromes
- Sepsis Diagnosis and Treatment
- Inflammasome and immune disorders
- Microscopic Colitis
- Psoriasis: Treatment and Pathogenesis
- Bladder and Urothelial Cancer Treatments
Queensland University of Technology
2017-2024
Translational Research Institute
2014-2021
Princess Alexandra Hospital
2019-2020
The University of Queensland
2012-2014
Brisbane School of Theology
2014
Children's Hospital of Los Angeles
2013
Greenslopes Private Hospital
2012
We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in community with chronic back pain.PRSs were developed validated European East Asian ethnicity, using data genome-wide association studies 15 585 AS 20 452 controls. The discriminatory values PRSs these populations compared other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 sacroiliac...
Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are strongly associated human leukocyte antigen (HLA)-B27, implying shared etiology. This study aims apply genomewide association (GWAS) characterize the genetic associations their relationship genetics AS. Methods: We undertook GWAS analyses 2752 AS (cases) 3836 without (controls). There were 7,436,415...
Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis common in Turkish and Iranian populations. Familial Mediterranean Fever (FMF) an autosomal recessive autoinflammatory disease most people of origin. MEFV, FMF-associated gene, also candidate gene for AS. We aimed to identify AS susceptibility loci examine the association between MEFV cohorts. performed genome-wide studies 1001 patients 1011 controls, 479 830 controls. Serum IL-1β, IL-17 IL-23 cytokine levels were...
Abstract Background Multiple studies have confirmed dysbiosis in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD); however, due to methodological differences across studies, it has not been possible determine if these diseases similar or different gut microbiomes. Results In this study, faecal intestinal biopsies were obtained from 33 Australian AS patients (including 5 with concomitant IBD, ‘AS-IBD’), 59 IBD 105 healthy controls. Stool samples also 16 Italian 136 Swedish...
We have identified a range of food phytochemicals that inhibit Janus Kinase 2 (JAK2) and Adenosine Monophosphate (AMPK). A mutated dysregulated form JAK2, tyrosine kinase, is associated with several diseases including Crohn's disease. Using an in vitro, time-resolved fluorescence (TR-FRET) assay, we tested 49 different types extracts, plus 10 concentrated fractions increasing hydrophobicity from each extract, to find foods containing JAK2 inhibitors. The extracts included grains, meat, fish,...
Abstract Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there been no published or polygenic risk score analyses of patients septic shock, despite evidence suggesting factors may be involved. We systematically collected genotype clinical outcome data in the context a randomized controlled trial from shock enrich presence disease-associated variants. performed genomewide susceptibility mortality using 493 2442 population controls,...
OBJECTIVES: We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used identify pathways of potential importance for understanding sepsis pathophysiology. DESIGN: Retrospective multicenter cohort studies patients. SETTING: All participants who were admitted 27 participating hospital sites three countries (Australia, New Zealand, and the United Kingdom) eligible inclusion. PATIENTS: Adult, critically ill, mechanically ventilated ( n...
<h3>Background</h3> Gout progresses through three stages: hyperuricemia, deposition of monosodium urate (MSU) crystals, and innate immune system response to MSU crystals. Genome wide association studies (GWAS) have provided insight into the molecular control progression hyperuricemia. However, less is known about from hyperuricemia gout. <h3>Objectives</h3> To conduct a GWAS for gout (where an crystals has occurred) using 5,835 cases - largest date. <h3>Methods</h3> The comprised 3 data...
You have accessJournal of UrologyPediatrics: Basic Research1 Apr 2012722 IDENTIFICATION OF EPIGENETIC CHANGES IN CHRONIC BLADDER INFLAMMATION In-Seon Choi, Kevin Yu, Erika De Guzman, Dan Weisenberger, Kyung Hwa Lee, Peter Laird, Jones, David Warburton, Gangning Liang, and Chester Koh ChoiIn-Seon Choi Los Angeles, CA More articles by this author , YuKevin Yu GuzmanErika Guzman WeisenbergerDan Weisenberger LeeKyung Lee LairdPeter Laird JonesPeter Jones WarburtonDavid Warburton LiangGangning...