Jason Meyer
A5033812811- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Respiratory Support and Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical studies and practices
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Family and Patient Care in Intensive Care Units
- Adrenal Hormones and Disorders
- Emergency and Acute Care Studies
- Pressure Ulcer Prevention and Management
- Long-Term Effects of COVID-19
- Acute Kidney Injury Research
- Inflammation biomarkers and pathways
- Genetic Associations and Epidemiology
- Vitamin C and Antioxidants Research
- Gut microbiota and health
- Clinical Reasoning and Diagnostic Skills
- Oral and gingival health research
- Inhalation and Respiratory Drug Delivery
Princess Alexandra Hospital
2019-2025
The George Institute for Global Health
2018-2024
Princess Alexandra Hospital
2023
St Joseph's Hospital Health Center
2010
Poliklinik für Endokrinologie, Diabetologie und Präventivmedizin
1999
The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Improving Global Outcomes (KDIGO) AKI criteria. This study aims to describe the epidemiology SA-AKI.This is retrospective cohort carried out in 12 intensive care units (ICUs) from 2015 2021. We studied incidence, patient characteristics, timing, trajectory, treatment, associated outcomes SA-AKI based on ADQI...
Importance Whether selective decontamination of the digestive tract (SDD) reduces mortality in critically ill patients remains uncertain. Objective To determine whether SDD in-hospital adults. Design, Setting, and Participants A cluster, crossover, randomized clinical trial that recruited 5982 mechanically ventilated adults from 19 intensive care units (ICUs) Australia between April 2018 May 2021 (final follow-up, August 2021). contemporaneous ecological assessment 8599 participating ICUs...
The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process outcome indicators in patients with hospital-acquired bloodstream infections (HABSI).
Traumatic brain injury (TBI) is a heterogeneous condition with broad spectrum of severity, pathophysiological processes and variable outcomes. For moderate-to-severe TBI survivors, recovery often protracted outcomes can range from total dependence to full recovery. Despite advances in medical treatment options, prognosis remains largely unchanged. The objective this study develop machine learning predictive model for neurological at 6 months patients TBI, incorporating longitudinal clinical,...
ABSTRACT Purpose: To examine the relationship of early persistent lymphopenia with hospital survival in critically ill patients and without sepsis to assess whether it can be considered a treatable trait. Methods: Retrospective database analysis nonelective admission intensive care units (ICUs) during January 2015 December 2018. Patients were classified as having if Acute Physiology Chronic Health Evaluation III diagnostic code included or coded for an infection combined Sequential Organ...
Abstract Purpose Older adults admitted to the intensive care unit (ICU) usually have fair baseline functional capacity, yet their age and frailty may compromise management. We compared characteristics management of older (≥ 75 years) versus younger hospitalized in ICU with hospital-acquired bloodstream infection (HA-BSI). Methods Nested cohort study within EUROBACT-2 database, a multinational prospective including 18 during 2019–2021. terms (clinical signs symptoms, source, microbiological...
Background Sepsis contributes significantly to morbidity and mortality globally. In Australia, 20,000 develop sepsis every year, resulting in 5,000 deaths, more than AUD$846 million expenditure. Prompt, appropriate antibiotic therapy is effective improving outcomes sepsis. Conventional culture-based methods identify have limited yield take days complete. Recently, nanopore technology has enabled rapid sequencing with real-time analysis of pathogen DNA. We set out demonstrate the feasibility...
Early recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently suboptimal the intensive care unit (ICU) setting. We describe feasibility Bayesian dosing software Individually Designed Optimum Dosing Strategies (ID-ODS™), to reduce time exposure children adults with ICU. A multi-centre prospective, non-randomised interventional trial three adult ICUs one paediatric In a pre-intervention Phase 1, we measured target...
Abstract Previous genetic association studies have failed to identify loci robustly associated with sepsis, and there been no published or polygenic risk score analyses of patients septic shock, despite evidence suggesting factors may be involved. We systematically collected genotype clinical outcome data in the context a randomized controlled trial from shock enrich presence disease-associated variants. performed genomewide susceptibility mortality using 493 2442 population controls,...
Objective: Lack of management guidelines for life-threatening asthma (LTA) risks practice variation. This study aims to elucidate practices LTA in the intensive care unit (ICU). Design: A retrospective cohort study. Setting: Thirteen participating ICUs Australia between July 2010 and June 2013. Participants: Patients with principal diagnosis LTA. Main outcome measures: Clinical history, ICU management, patient outcomes, ward education discharge plans. Results: Of 270 (267 patients)...
Although critically ill patients with bloodstream infections (BSIs) who present hypothermia are at the highest risk for death, it is not known how rewarming rates may influence outcomes. The objective of this study was to identify occurrence and determinants among admitted intensive care units (ICUs) BSI assess rate temperature correction 90-day all-cause case-fatality. A cohort 3951 ICU admissions associated assembled. lowest measured within first 24 hours admission identified, those were...
OBJECTIVES: We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used identify pathways of potential importance for understanding sepsis pathophysiology. DESIGN: Retrospective multicenter cohort studies patients. SETTING: All participants who were admitted 27 participating hospital sites three countries (Australia, New Zealand, and the United Kingdom) eligible inclusion. PATIENTS: Adult, critically ill, mechanically ventilated ( n...
Objective: To obtain an accurate estimate of smoking prevalence and cessation support practices, including nicotine replacement therapy (NRT), in Australian New Zealand intensive care units (ICUs). Design, setting participants: Cross-sectional, observational study using data obtained from adult ICUs participating the Intensive Care Society Clinical Trials Group Point Prevalence Program 2016. Main outcome measures: intensity current smoking, baseline characteristics smokers comparison with...