A5100729703- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Renal function and acid-base balance
- Heart Rate Variability and Autonomic Control
- Ultrasound in Clinical Applications
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Thermoregulation and physiological responses
- Cardiovascular Health and Disease Prevention
- Clinical Reasoning and Diagnostic Skills
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Risk Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Emergency and Acute Care Studies
- Dialysis and Renal Disease Management
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Neurotoxicity Research
- COVID-19 impact on air quality
- Ferroptosis and cancer prognosis
- Clinical Nutrition and Gastroenterology
Zhejiang Hospital
2016-2025
Zhejiang University
2024
Zhejiang Chinese Medical University
2023
Yan'an University
2021
Nanjing University of Chinese Medicine
2018-2019
Huazhong University of Science and Technology
2019
Tongji Hospital
2019
Wenzhou Medical University
2019
Abstract Objective To evaluate whether the immunomodulatory drug thymosin α1 reduces mortality in adults with sepsis. Design Multicentre, double blinded, placebo controlled phase 3 trial. Setting 22 centres China, September 2016 to December 2020. Participants 1106 aged 18-85 years a diagnosis of sepsis according sepsis-3 criteria and randomly assigned 1:1 ratio receive (n=552) or (n=554). A stratified block method was used for randomisation, participants were by age (<60 ≥60 years)...
Limited studies investigated the effects of long-term ozone exposure on cardiometabolic health. We aimed to examine association with a range diseases, as well subclinical indicators in Eastern China. The study included 202,042 adults living 11 prefecture-level areas Zhejiang Province between 2014 and 2021. Using satellite-based model 1 × km spatial resolution, we estimated residential 5-year average exposures for each subject. Mixed-effects logistic linear regression models were applied...
Abstract Purpose Older adults admitted to the intensive care unit (ICU) usually have fair baseline functional capacity, yet their age and frailty may compromise management. We compared characteristics management of older (≥ 75 years) versus younger hospitalized in ICU with hospital-acquired bloodstream infection (HA-BSI). Methods Nested cohort study within EUROBACT-2 database, a multinational prospective including 18 during 2019–2021. terms (clinical signs symptoms, source, microbiological...
Comprehensive geriatric assessment is the major approach in screening syndrome. The aim of this expert consensus to supply standard operating procedures for clinical practice comprehensive China.
1. Peroxisome proliferator-activated receptor (PPAR)-gamma agonists have been demonstrated to exert protective effects against homocysteine (Hcy)-induced pathogenesis. However, the of PPAR-gamma on Hcy-induced migration are unknown. In present study, we examined effect pioglitazone vascular smooth muscle cells (VSMC) induced by Hcy and possible mechanism involved. 2. Vascular were isolated from thoracic aortas male Sprague-Dawley rats. The VSMC was using a transwell technique. generation...
Objective. To investigate the immunomodulatory effect of glutamine (Gln)-enriched nutritional support in elderly patients with severe sepsis an intensive care unit (ICU). Material and methods. A total 110 [acute physiology chronic health evaluation (APACHE)-II score ≥16 but ≤28 D-related human leukocyte antigen (HLA-DR) expression ≤50%] were included a prospective, randomized, controlled clinical study. The divided into two groups: control group (n=55) received standard isonitrogenous,...
Sepsis is the leading cause of death among critically ill patients. Herein, we conducted a national survey to provide data on epidemiology and treatment sepsis in clinical practice China, which has no detailed epidemiological available sepsis.This was prospective cross-sectional from December 1, 2015 January 31, 2016 all provinces/municipalities mainland China. The primary outcome this study incidence sepsis, secondary its etiology Patients with admitted Intensive Care Units were included...
Cardiovascular disease (CVD) has been the most critical health problem in China. Large number of researches and clinical experiments demonstrated that home healthcare helps detect CVD at early stage. This work designed a mobile system. Physiological signals are acquired by portable apparatus transferred to gateway or personal devices finally community center. General practitioners could analyze related indices reply users along with report, which provides status daily care suggestions.
Abstract Background Acute respiratory distress syndrome (ARDS), a complex response to various insults, has high mortality rate. As pulmonary edema resulting from increased vascular permeability is hallmark of ARDS, management the fluid status, including urine output (UO) and intake (FI), essential. However, relationships between UO, FI, in ARDS remain unclear. This retrospective study aimed investigate interactive associations among ARDS. Methods was secondary analysis prospective randomized...
Fluid balance (FB) is associated with poor sepsis outcomes; however, it cannot accurately reflect the dynamic fluid accumulation status. Here, we explored a new index, FB to intake ratio (FB/FI), for evaluating in sepsis. FB/FI values within 48 hours were recorded. Their association in-hospital mortality was investigated using logistic regression and mediation analyses of data from 7,839 patients. In extended models, linear found between (odds [OR]: 1.05-1.08, p < 0.001). However, this...
Introduction . Heart failure (HF) is a common and potentially fatal condition. Cardiovascular research has focused on medical therapy for HF. Theoretical modelling could enable simulation evaluation of the effectiveness medications. Furthermore, models also help predict patients’ cardiac response to treatment which will be valuable clinical decision-making. Methods This study presents fast parameters estimation algorithm constructing cardiovascular model medicine evaluation. The outcome HF...
Klotho is a type of single‑pass transmembrane protein that important for the proper function numerous organs. The aim present study was to investigate role in sepsis‑associated myocardial damage. In study, reverse transcription‑quantitative PCR, western blotting and ELISA were conducted examine expression levels genes, flow cytometry performed detect cell apoptosis reactive oxygen species. demonstrated significantly downregulated septic mice improved after treatment with exogenous protein....
Compliance with recommended pharmacological and non-pharmacological treatments to modify risk factors is associated improved outcomes for patients heart failure (HF).We conducted an analysis of the National Health Nutrition Examination Survey (NHANES) years 1999-2018 evaluate adequacy factor control compliance lifestyle medications according clinical guidelines management HF. Demographic, clinical, healthcare-access having uncontrolled or not receiving were determined using logistic...
Background Sepsis is marked by a dysregulated immune response to infection. Calcineurin inhibitors (CNIs), commonly used as immunosuppressants, have unique properties that may help mitigate the overactive in sepsis, potentially leading better patient outcomes. This study aims assess whether CNIs improve prognosis septic patients and evaluate any associated adverse reactions. Methods We utilized Medical Information Mart for Intensive Care IV 2.2 (MIMIC-IV 2.2) database identify who were...