A5108122296- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Metal-Organic Frameworks: Synthesis and Applications
- Membrane Separation and Gas Transport
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Synthesis and biological activity
- CNS Lymphoma Diagnosis and Treatment
- Heavy metals in environment
- Analytical Chemistry and Chromatography
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Lymphoma Diagnosis and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Chronic Lymphocytic Leukemia Research
- Covalent Organic Framework Applications
- RNA regulation and disease
- Medical and Biological Ozone Research
- Cancer Mechanisms and Therapy
- Macrophage Migration Inhibitory Factor
- Plant Micronutrient Interactions and Effects
- CRISPR and Genetic Engineering
Gansu University of Traditional Chinese Medicine
2013-2025
Sir Run Run Shaw Hospital
2023-2024
Zhejiang University
2012-2024
Beijing Tian Tan Hospital
2024
Jiujiang University
2024
Northwest Normal University
2024
Capital Medical University
2024
North Sichuan Medical University
2024
Shandong University
2024
Shanghai Ocean University
2024
The successful integration of the SPECM measurement technique to provide deeper insights into underlying mechanisms responsible for improved ECL performance is reported.
Patients with relapsed/refractory primary central nervous system lymphoma (R/R PCNSL) usually have a poor prognosis and limited treatment options. We respectively reviewed 38 patients R/R PCNSL treated zanubrutinib-based regimens in our center. The overall response rate, complete rate disease control were 76.3%, 47.4% 92.1%, respectively. median progression-free survival (PFS) was 31.0 months, the (OS) not reached. Unitivariate analysis by Cox's proportional hazards model revealed that (vs....
Giant meniscus cysts combined with mixed tears are relatively uncommon in clinical practice. The primary objective of rehabilitation is to restore knee joint function and prevent cyst recurrence. In this article, we discuss a series strategies implemented for patient who experienced both giant tear.
To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (MSCs) by intra-articular injection for degenerative knee osteoarthritis.Between January 2015 2016, 36 patients with moderate or severe osteoarthritis were randomly devided into 2 groups (n=18). Intra-articular 2.5-3.0 mL MSCs suspension containing (2-3)×107 was performed once a month times as course treatment in cell group; sodium hyaluronate used week 5 control group. There no significant difference...
Abstract Background The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research this plant during growth necessary. Results Principal component analysis the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. chemical markers accounting for separations were identified from PCA loadings plot. These further verified by accurate mass tandem retention times available reference standards. study has shown accumulation...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of circular RNA SUMOylation in the development ICC remain poorly understood. Circular hsa_circ_0001681 (termed Circ-RAPGEF5 hereafter) was identified by sequencing from 19 pairs adjacent tissue samples. biological function tumor proliferation metastasis examined series vitro assays. A preclinical model used to validate therapeutic effect targeting Circ-RAPGEF5....
Acquired resistance to chemotherapy is one of the major causes mortality in advanced nasopharyngeal carcinoma (NPC). However, effective strategies are limited and underlying molecular mechanisms remain elusive. In this study, through transcriptomic profiling analysis 23 tumor tissues, we found that NOTCH3 was aberrantly highly expressed chemoresistance NPC patients, with overexpression being positively associated poor clinical outcome. Mechanistically, using an established cellular model,...
Accelerated senescence is triggered by key mediators of arrhythmogenic substrates and contributes to atrial fibrillation (AF). We sought understand in AF the extent which it aggravates process. Twenty-six patients undergoing open-heart surgery were included, 12 with sinus rhythm served as controls. Another cohort included 120 consecutive persistent valvular heart diseases. HL-1 myocytes tachypaced (TP) simulate experimental AF. Compared rhythm, left appendages (LAAs) presented a...
A label-free and ultrasensitive electrochemical biosensor for oral cancer overexpressed 1 (ORAOV1) gene was constructed via exonuclease III-assisted target recycling dual enzyme-assisted signal amplification strategies. Capture DNA with a sulfhydryl group at its 3' terminus modified onto the surface of bare gold electrode an Au-S bond. Assisted hybridized basal to form hybrid in advance, ORAOV1 continuously such from other construct intact double-stranded DNA. Exonuclease III digested...
Our previous study identified round scad neuroprotective peptides with different characteristics. However, the intrinsic relationship between their structure and bioactivity, as well bioavailability, remains unclear. The aim of this is to elucidate bioavailability these structure-activity against neuroinflammation. Results showed that SR WCP were resistant gastrointestinal digestion. Additionally, SR, WCP, WCPF could transport Caco-2 monolayers intact peptides. permeability coefficients (