A5100729705- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Wireless Body Area Networks
- Inflammatory Biomarkers in Disease Prognosis
- Eosinophilic Esophagitis
- IoT and Edge/Fog Computing
- Antibiotic Use and Resistance
- ECG Monitoring and Analysis
- Sepsis Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Acute Kidney Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Global Maternal and Child Health
- Aortic aneurysm repair treatments
- interferon and immune responses
- vaccines and immunoinformatics approaches
Zhejiang Hospital
2013-2024
The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process outcome indicators in patients with hospital-acquired bloodstream infections (HABSI).
Abstract Background Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) a recent marker that reflects the balance between inflammation immune response. Despite wealth of information available on bilirubin’s diverse functionalities, potential correlation total bilirubin (TB) levels SII has not been investigated so far. Methods Leveraging data from National...
Evidence has been shown that indoxyl sulfate (IS) could impair kidney and cardiac functions. Moreover, macrophage polarization played important roles in chronic disease cardiovascular disease. IS acts as a nephron-vascular toxin, whereas its effect on during inflammation is still not fully elucidated. In this study, we aimed to investigate the of lipopolysaccharide (LPS) challenge. THP-1 monocytes were incubated with phorbol 12-myristate-13-acetate (PMA) differentiate into macrophages, then...
The human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial many biomedical clinical settings. Utilizing Sanger sequencing, golden standard technology for HLA typing enables accurate identification of alleles high-resolution. However, only commercial software, such as uTYPE, SBT-Assign, SBTEngine, very few open-source tools could be applied to perform based on sequencing.We developed user-friendly, cross-platform desktop application, known...
Abstract Lipopolysaccharide (LPS) could induce apoptosis and dysfunction of endothelial cells. We aimed to reveal the effects macrophages on cell proliferation in LPS induced human umbilical vein cells (HUVECs). THP-1 derived HUVECs were co-cultured presence LPS. Cell viability was measured by Counting Kit-8 analyzed flow cytometry. Expression Ang1, NF-κB component p65 evaluated western blot quantitative PCR. Small interfering RNAs (siRNAs) used knockdown expression proinflammatory cytokines...
Viruses have become a major threat to human health. Interferon-β (IFN-β) has key role in the antivirus process, as it can increase expression of antivirus-associated genes. Itaconate and its derivatives regulate immune response, secretion inflammatory factors, pyroptosis macrophages. The effect itaconate on IFN-β double-stranded RNA-induced macrophages are not well known. A derivative itaconate, 4-octoyl (4-OI), was used treat mouse bone marrow-derived (BMDM) induced with 100 μg/mL...
Abstract Neutrophils have crucial roles in defensing against infection and adaptive immune responses. This study aimed to investigate the genetic mechanism neutrophils response sepsis-induced immunosuppression. The GSE64457 dataset was downloaded from Gene Expression Omnibus database neutrophil samples (D3-4 D6-8 post sepsis shock) were assigned into two groups. differentially expressed genes (DEGs) identified. Short Time-series Miner (STEM) clustering analysis conducted select consistently...
ABSTRACT Summary The human leukocyte antigen (HLA) gene family plays a key role in the immune response and thus is crucial many biomedical clinical settings. Utilizing Sanger sequencing - gold standard technology for HLA typing – enables accurate identification of alleles with high-resolution. However, there exists current hurdle that only commercial software such as UType, SBT-Assign SBTEngine, instead any open source tools could be applied to perform based on sequencing. To fill gap, we...
Background : Lipopolysaccharide (LPS) desensitization, which is characterized by hyporesponsiveness and a form of immunosuppression, important in the negative regulation responses to LPS inflammatory disease such as sepsis. However, effect IL-33 desensitization remains unclear. Methods We used RNA-sequencing technology analyze changes mRNA bone-marrow-derived macrophages (BMDMs) stimulated with LPS. Changes expression secretion cytokines were detected qPCR ELISA, respectively. Mechanisms...