A5057256585- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Obstructive Sleep Apnea Research
- Ocular Surface and Contact Lens
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Music and Audio Processing
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Tracheal and airway disorders
- Clinical Nutrition and Gastroenterology
- Ocular Infections and Treatments
- Privacy, Security, and Data Protection
- Airway Management and Intubation Techniques
- Plant Molecular Biology Research
- Web Data Mining and Analysis
- Hemoglobinopathies and Related Disorders
- Genetic Neurodegenerative Diseases
- Infectious Encephalopathies and Encephalitis
- Head and Neck Anomalies
- Antifungal resistance and susceptibility
Riley Hospital for Children
2025
Indiana University School of Medicine
2023-2024
Indiana University
2023-2024
Kitware (United States)
2024
FPT University
2023-2024
Ho Chi Minh City University of Technology
2024
Vietnam National University Ho Chi Minh City
2024
Logan Hospital
2013-2023
The University of Queensland
2009-2023
Dong A University
2023
Fuchs's corneal dystrophy (FCD) is a leading cause of transplantation and affects 5% persons in the United States who are over age 40 years. Clinically visible deposits called guttae develop under endothelium patients with FCD. A loss endothelial cells deposition an abnormal extracellular matrix observed microscopically. In advanced disease, cornea swells becomes cloudy because remaining not sufficient to keep dehydrated clear. Although rare genetic variation that contributes both...
Regulation of stem cell self-renewal versus differentiation is critical for embryonic development and adult tissue homeostasis. Drosophila larval neuroblasts divide asymmetrically to self-renew, are a model system studying self-renewal. Here we identify three mutations showing increased brain neuroblast numbers that map the aurora-A gene, which encodes conserved kinase implicated in human cancer. Clonal analysis time-lapse imaging mutants show single generate multiple (ectopic self-renewal)....
While it is accepted that a majority of invasive breast cancer progresses from ductal carcinoma in situ (DCIS) precursor stage, very little known about the factors promote survival DCIS neoplastic cells within hypoxic, nutrient deprived intraductal microenvironment.We examined hypothesis fresh human lesions contain pre-existing cells. We characterized these by full genome molecular cytogenetics (Illumina HumanCytoSNP profile), and signal pathway profiling (Reverse Phase Protein Microarray,...
Here, we describe the embryonic central nervous system expression of 5,000 GAL4 lines made using molecularly defined cis-regulatory DNA inserted into a single attP genomic location. We document and annotate patterns in early embryos when neurogenesis is at its peak, older where there maximal neuronal diversity first neural circuits are established. note other tissues, such as lateral body wall (muscle, sensory neurons, trachea) viscera. Companion papers report on adult brain larval imaginal...
To assess behavior and quality of life in children with obstructive sleep apnea (OSA) undergoing tonsillectomy adenoidectomy compared control children.Prospective controlled study.Hospital-based pediatric otolaryngology practice.Forty-two (25 boys 17 girls; mean [SD] age, 5.8 [2.5] years) OSA confirmed by positive findings on polysomnography 41 (29 12 7.3 [3.8] no history snoring unrelated elective surgery.Parents completed the standardized Child Behavior Checklist a validated...
Crustaceans possess remarkably diverse appendages, both between segments of a single individual as well species. Previous studies in wide range crustaceans have demonstrated correlation the anterior expression boundary homeotic (Hox) gene Ultrabithorax (Ubx) and location number specialized thoracic feeding called maxillipeds. Given that Hox genes regulate regional identity organisms mice flies, these observations led to hypothesis Ubx regulates maxillipeds evolutionary changes generated...
To compare outcomes from early post-pyloric to gastric feeding in ventilated, critically ill patients a medical intensive care unit (ICU). Prospective randomized study. Ventilated were randomly assigned receive enteral feed via nasogastric or tube. Post-pyloric tubes inserted by the bedside nurse and placement was confirmed radiographically. A total of 104 enrolled, 54 group 50 group. Bedside tube insertion successful 80% patients. Patients who failed fed route, but analysed on an intent-to...
Purpose: To determine graft quality and feasibility of Descemet membrane endothelial keratoplasty (DMEK) grafts that are prestripped preloaded into injectors by eye bank technicians before shipping to surgeons. Methods: DMEK (n = 31) were prepared from donor corneas Straiko Modified Jones tubes set inside viewing chambers filled with 20 mL Optisol-GS. Preloaded evaluated using specular microscopy slit-lamp biomicroscopy. Endothelial cell loss (ECL) was captured vital dye staining quantified...
Purpose: To describe the technique, advantages, and early complication rates of using Descemet membrane endothelial keratoplasty (DMEK) donor tissue that is prestained preloaded into an injector at eye bank delivered in a storage medium to surgeon for transplantation 1 2 days later. Methods: A total 111 eyes with failure underwent DMEK donors were prestripped, prestained, S-stamped, Straiko modified Jones tube Optisol-filled viewing chamber Scroll tightness, time unscroll center tissue,...
Objective: The authors’ goal was to compare the size and linear density of Purkinje cells in cerebellar vermis subjects with without schizophrenia. Method: Blocks alcohol-fixed were dissected at autopsy from brains 14 elderly patients schizophrenia 13 no history neuropsychiatric illness. blocks sectioned stained 1% cresyl violet. cross-sectional area measured by using computer-assisted image analysis. had been assessed clinical rating scales within 1 year prior death.Results: average areas...
Neurogenesis in Drosophila and mammals requires the precise integration of spatial temporal cues. In Drosophila, embryonic neural progenitors (neuroblasts) sequentially express transcription factors Hunchback, Kruppel, Pdm1/Pdm2 (Pdm) Castor as they generate a stereotyped sequence neuronal glial progeny. Hunchback Kruppel specify early identity two posterior neuroblast lineages (NB7-1 NB7-3), whereas Pdm late NB7-1 lineage. Because have only been assayed one lineage, it is unknown whether...
Purpose To evaluate the clinical feasibility and visual outcomes of allograft corneal ring segment implantation for treatment keratoconus. Methods This case series, included forty-four eyes 32 patients with a 6-month follow-up. All cases were treated according to Istanbul nomogram. In Nomogram, tunnels 4 × 7.5 mm diameters are created at depth 200 μm implanted sterile rings (KeraNaturalTM, Lions VisionGift, Portland, OR, USA) cone location. Uncorrected distance acuity (UDVA), corrected...
Decision-making for elective cleft lip and nose revisions varies widely, from patient-led decisions to more paternalistic approaches. As these procedures incur additional scarring that may impact future interventions, patients should be equipped participate in surgical decisions. We thus developed a decision aid based on international standards, ensure methodologic rigor, we sought feedback other surgeons regarding shared decision-making potential barriers adopting the aid. The was...
Objective Spiritual distress describes an “impaired ability to experience and integrate meaning purpose,” frequently occurring after receipt of a major diagnosis. We measured spiritual in caregivers children presenting multidisciplinary cleft craniofacial clinic, hypothesizing that significant percentage would demonstrate distress. Design Caregivers were surveyed utilizing the Functional Assessment Chronic Illness Therapy—Spiritual Well-Being scale, non-illness version (FACIT-Sp 12),...
Abstract Thermoelectric generators (TEGs) provide an innovative approach to converting waste heat into electricity. However, practical application of TEGs is constrained by the limited thermoelectric performance traditional materials like bismuth telluride (Bi₂Te₃)-based materials. Thick films frequently suffer from cracking, leading reduced reliability and efficiency. To overcome these limitations, this study investigates incorporation cellulose nanofibers (CNF) Bi₂Te₃-based films. CNF, a...
To examine endothelial cell damage and stain retention of prestained preloaded Descemet membrane keratoplasty (DMEK) grafts.DMEK grafts were stained with trypan blue or left unstained before loading into a Straiko modified Jones tube. A protocol to inside the tube resulting loss was also examined. Endothelial determined by vital dye staining after 3 days cold storage compared between groups. Eight additional stained, loaded, shipped from Oregon New York assess stability. Stain ability...
Early warning tools have been widely implemented without evidence to guide (a) recognition and (b) response team expertise optimisation. With growing databases from MET-calls digital hospitals, we now access guiding information. The Queensland Adult-Deterioration-Detection-System (Q-ADDS) is used requires validation.Compare the accuracy of Q-ADDS National Warning Score (NEWS), Between-the-Flags (BTF) electronic Cardiac Arrest Risk Triage (eCART)).Data Chicago University hospital database...
The Hunchback/Ikaros family of zinc-finger transcription factors is essential for specifying the anterior/posterior body axis in insects, fate early-born pioneer neurons Drosophila, and retinal immune development mammals. proteins can directly activate or repress target gene during early insect development, but their mode action neural unknown. Here, we use recombineering to generate a series Hunchback domain deletion variants assay function neurogenesis absence endogenous Hunchback....
ABSTRACT Background and objective: Previous studies have demonstrated an increased incidence of sleep apnoea in spinal cord‐injured patients. Many these were performed long‐term, stable cord injury (SCI). The aims this study were: (i) to determine the prevalence sleep‐disordered breathing (SDB) acute SCI; (ii) document change SDB over time during rehabilitation period; (iii) correlate degree with ventilatory parameters. Methods: Sixteen subjects SCI level T12 above complete motor impairment...