A5018736336- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Influenza Virus Research Studies
- Family and Patient Care in Intensive Care Units
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
- Disaster Response and Management
- Healthcare Decision-Making and Restraints
- Thermal Regulation in Medicine
- Trauma and Emergency Care Studies
- Anesthesia and Neurotoxicity Research
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Acute Kidney Injury Research
- Palliative Care and End-of-Life Issues
- Respiratory viral infections research
Nepean Hospital
2016-2025
The University of Sydney
2014-2025
The George Institute for Global Health
2013-2024
University of Southern Denmark
2024
University of Ottawa
2024
Royal North Shore Hospital
2012-2024
Ottawa Hospital
2024
Université de Montréal
2024
University of Milano-Bicocca
2023
UNSW Sydney
2012-2023
It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumatic brain injury and refractory raised intracranial pressure.From December 2002 through April 2010, we randomly assigned 155 adults diffuse hypertension that was to first-tier therapies undergo either bifrontotemporoparietal or standard care. The original primary an unfavorable (a composite of death, vegetative state, disability), as evaluated on Extended Glasgow Outcome Scale 6...
Planning for the treatment of infection with 2009 pandemic influenza A (H1N1) virus through health care systems in developed countries during winter Northern Hemisphere is hampered by a lack information from similar systems.We conducted an inception-cohort study all Australian and New Zealand intensive units (ICUs) Southern Hemisphere. We calculated, per million inhabitants, numbers ICU admissions, bed-days, days mechanical ventilation due to H1N1 virus. collected data on demographic...
Choice and intensity of early (first 48 h) sedation may affect short- long-term outcome.To investigate the relationships between time to extubation, delirium, hospital 180-day mortality among ventilated critically ill patients in intensive care unit (ICU).Multicenter (25 Australia New Zealand hospitals) prospective longitudinal (ICU admission 28 d) cohort study medical/surgical sedated 24 hours or more. We assessed administration sedative agents, ventilation time, depth using Richmond...
Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration mechanical ventilation delirium among patients in intensive care unit (ICU). The use dexmedetomidine as sole or primary sedative agent undergoing has not been extensively studied.
Objectives: To develop a comprehensive set of items describing physiotherapy mobilisation practices for critically ill patients, and to document current in intensive care units Australia New Zealand, focusing on patients having > 48 hours mechanical ventilation. Design: Prospective, observational, multicentre, single-day, point prevalence study. Participants setting: All 38 Australian Zealand ICUs at 10 am one three designated days 2009 2010. Main outcome measures: Demographic data,...
In the absence of a universal definition light or deep sedation, level sedation that conveys favorable outcomes is unknown. We quantified relationship between escalating intensity in first 48 hours mechanical ventilation and 180-day survival, time to extubation, delirium.Harmonized data from prospective multicenter international longitudinal cohort studies SETTING:: Diverse mix ICUs.Critically ill patients expected be ventilated for longer than 24 hours.Richmond Agitation Sedation Scale pain...
Participants All women with 2009 H1N1 influenza who were pregnant or recently post partum and admitted to an intensive care unit in Australia New Zealand between 1 June 31 August 2009.
Objective: To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. Design: Pilot prospective, multicenter, randomized, controlled trial. Setting: Six ICUs. Patients: Critically ill adults mechanically ventilated for greater than 24 hours. Interventions: Patients randomized to received a dexmedetomidine-based algorithm targeted light (Richmond Agitation Sedation Score –2 1). propofol and/or midazolam-based as clinically appropriate....
Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been proposed to decrease improve the accuracy of tracheal puncture. We aimed compare procedural safety efficacy real-time with traditional landmark approach during percutaneous dilatational tracheostomy (PDT).A total 50 undergoing PDT for clinical indications were randomly assigned, after...
Abstract Background Septic shock is associated with decreased vasopressor responsiveness. Experimental data suggest that central alpha2-agonists like dexmedetomidine (DEX) increase responsiveness and reduce catecholamine requirements in septic shock. However, DEX may also cause hypotension bradycardia. Thus, it remains unclear whether hemodynamically safe or helpful this setting. Methods In post hoc subgroup analysis of the Sedation Practice Intensive Care Evaluation (SPICE III) trial, an...
Functional outcomes at 12 months were a secondary outcome of the randomized DECRA trial early decompressive craniectomy for severe diffuse traumatic brain injury (TBI) and refractory intracranial hypertension. In trial, patients randomly allocated 1:1 to either or intensive medical therapies (standard care). We conducted planned analyses 6 months, including all 155 patients. measured functional using Glasgow Outcome Scale-Extended (GOS-E). used ordered logistic regression, dichotomized GOS-E...
To investigate the changes in B-type natriuretic peptide concentrations patients with severe sepsis and septic shock to value of predicting intensive care unit outcomes.Prospective observational study.General unit.Forty or shock.None.B-type measurements echocardiography were carried out daily for 10 consecutive days. In-hospital mortality length stay recorded. The admission generally increased (747 +/- 860 pg/mL). levels elevated normal left ventricular systolic function (568 811 pg/mL),...
Please cite this paper as: Blyth et al. (2013) The impact of bacterial and viral co‐infection in severe influenza. Influenza Other Respiratory Viruses 7(2) 168–176. Background Many questions remain concerning the burden, risk factors patients with pandemic influenza admitted to intensive care unit (ICU). Objectives To examine Australian Patients/Methods A cohort study conducted 14 ICUs was performed. Patients proven during 2009 season were eligible for inclusion. Demographics, factors,...
Abstract Introduction Acute heart failure (AHF) is characterized by inadequate cardiac output (CO), congestive symptoms, poor peripheral perfusion and end-organ dysfunction. Treatment often includes a combination of diuretics, oxygen, positive pressure ventilation, inotropes vasodilators or vasopressors. Lactate marker illness severity but also an important metabolic substrate for the myocardium at rest during stress. We tested effects half-molar sodium lactate infusion on performance in...
ABSTRACT Colonization with Candida species is an independent risk factor for invasive candidiasis (IC), but the minimum and most practicable parameters prediction of IC have not been optimized. We evaluated colonization in a prospective cohort 6,015 nonneutropenic, critically ill patients. Throat, perineum, urine were sampled 72 h post-intensive care unit (ICU) admission twice weekly until discharge or death. Specimens cultured onto chromogenic agar, subset underwent molecular...
Background and Purpose— EG-1962 is a sustained release formulation of nimodipine administered via external ventricular drain in patients with aneurysmal subarachnoid hemorrhage. A randomized, open-label, phase 1/2a, dose-escalation study provided impetus for this to evaluate efficacy safety single intraventricular 600 mg dose hemorrhage, compared standard care oral nimodipine. Methods— Subjects were World Federation Neurological Surgeons grades 2–4, modified Fisher 2–4 had an inserted as...
Uncertainties remain about the safety and efficacy of therapies for managing intracranial hypertension in acute brain injured (ABI) patients. This study aims to describe therapeutical approaches used ABI, with/without pressure (ICP) monitoring, among different pathologies across countries, their association with six months mortality neurological outcome.A preplanned subanalysis SYNAPSE-ICU study, a multicentre, prospective, international, observational cohort describing ICP treatment, graded...
BackgroundThe effect of a liberal red-cell transfusion strategy as compared with restrictive in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.MethodsWe randomly assigned critically ill adults acute and anemia to (mandatory at hemoglobin level ≤10 g per deciliter) or (optional ≤8 deciliter). The primary outcome was unfavorable neurologic outcome, defined score 4 higher on modified Rankin scale (range, 0 6, scores indicating greater disability)...
Venous thromboembolism (VTE) is a common complication of acute illness, and its prevention ubiquitous aspect inpatient care. A multicenter blinded, randomized trial compared the effectiveness most pharmocoprevention strategies, unfractionated heparin (UFH) low-molecular-weight (LMWH) dalteparin, finding no difference in primary end point leg deep-vein thrombosis but reduced rate pulmonary embolus heparin-induced thrombocytopenia among critically ill medical-surgical patients who received...
Tension pneumomediastinum is a rare and life-threatening complication of mediastinal emphysema which can occur with mechanical ventilation. We present case tension mediastinum associated ventilation in patient Acute Respiratory Distress Syndrome due to Pneumocystis jirovecii pneumonia. discuss the mechanism pathophysiology pneumomediastinum, potential association pneumonia recruitment manouvres, its definitive emergency treatment.